Mechanisms and Therapeutic Opportunities in Atrial Fibrillation in Relationship to Alcohol Use and Abuse

Linz, Benedikt; Hertel, Julie Norup; Jespersen, Thomas; Linz, Dominik

doi:10.1016/j.cjca.2022.04.009

Cited by 13 publications

(8 citation statements)

References 110 publications

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“…Alcohol plays a signi cant role in generating AF through various mechanisms, such as altering the electrical properties of the atria, characterized by shortening of refractoriness, slowing conduction velocity, and increasing ectopic beats. It also induces changes in the structure and function of atrial cardiomyocytes, leading to brosis, and autonomic imbalance [18,19,20,21]. All of this, combined with myocardial in ammation and brosis, which can be caused by DM [known as diabetic cardiomyopathy], further increases the likelihood of developing AF [11,12,22].…”

Section: Discussionmentioning

confidence: 99%

Associated Factors to Atrial Fibrillation in Diabetics at a Peruvian Northern Hospital

Vilela-Farfán,

Rodriguez-Saldaña,

Fiestas-Cordova

et al. 2024

Preprint

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Studies have demonstrated that patients with diabetes mellitus have higher risk of developing Atrial Fibrillation compared to those without Diabetes Mellitus. The aim of this research was to identify the factors associated with AF in diabetic patients in Piura, Peru. A cross-sectional study included diabetic patients over 18 years old, treated in the internal medicine department for hospitalization, emergencies, and referrals. Conducted at a Hospital, located in Piura in northern Peru. A frequency of 50.36% of diabetic patients with AF was determined. For the adjusted model, age, alcoholism, and elevated glycosylated hemoglobin levels were considered for inclusion, in addition to gender due to biological reasoning to suspect an association with AF. Only age (Adjusted Prevalence Ratio (aPR): 0.97; 95% CI: 0.968-0.987; p-value < 0.001) and alcoholism (aPR: 1.44; 95% CI: 1.132-1.835; p-value = 0.003) were found as associated factors. Being younger and having alcoholism were significantly associated with the onset of atrial fibrillation in diabetic patients.

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Section: Discussionmentioning

confidence: 99%

Associated Factors to Atrial Fibrillation in Diabetics at a Peruvian Northern Hospital

Vilela-Farfán,

Rodriguez-Saldaña,

Fiestas-Cordova

et al. 2024

Preprint

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“…Existing research has indicated that atria in AF patients typically exhibits pronounced electrophysiological instability, characterized by marked alterations in atrial myocyte excitability and repolarization times (17,18). This instability precipitates disordered conduction of electrical signals within the atria, thereby fostering the onset of AF (19). Furthermore, investigators have identi ed structural changes within the atria, such as atrial enlargement or brosis, in part of AF patients, which further exacerbate the severity of the arrhythmia (20,21).…”

Section: Discussionmentioning

confidence: 99%

Single-cell sequencing combined with Bulk RNA-Seq to explore the molecular mechanism of cell communication in atrial fibrillation

Wu,

Zhong,

Chen

et al. 2023

Preprint

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Atrial fibrillation (AF) represents a rapid atrial arrhythmia and is associated with the potential for adverse cardiovascular outcomes, the precise pathophysiological mechanisms underpinning AF remain incompletely elucidated. In the present study, the single-cell dataset GSE224995 was retrieved from the Gene Expression Omnibus (GEO) database, and its utilization facilitated the identification of cell subtypes involved in AF. Weighted Gene Co-expression Network Analysis (WGCNA) was constructed to systematically identify crucial gene models. We also conduct comprehensive immune infiltration analysis, perform functional enrichment analysis, and elucidate the intricate associations between these pivotal genes and regulatory genes governing AF. Five cell subtypes were identified using single-cell sequencing, the most active cell subtype, tissue stem cell, was identified by cell communication analysis, and 20 gene modules were identified by WGCNA algorithm. We intersect the marker gene of tissue stem cell with the WGCNA module mostly associated AF and eventually ascertained with three key biomarkers, including are ABTB2, NAV2 and RBFOX1. These novel biomarkers for AF hold substantial promise in offering novel insights for the prevention and therapeutic intervention of this condition.

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“…3 Currently, there is limited knowledge on the role of chemicals on toxic metals on AF. The best-studied chemical in the context of AF is alcohol, which has been linked with incidence of AF, especially when it is consumed in large quantities as has been documented in other reviews on this topic 70,71…”

Section: Other Environmental Chemicalsmentioning

confidence: 99%

Environmental Exposome and Atrial Fibrillation: Emerging Evidence and Future Directions

Wass,

Hahad,

Asad

et al. 2024

Circulation Research

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There has been increased awareness of the linkage between environmental exposures and cardiovascular health and disease. Atrial fibrillation is the most common sustained cardiac arrhythmia, affecting millions of people worldwide and contributing to substantial morbidity and mortality. Although numerous studies have explored the role of genetic and lifestyle factors in the development and progression of atrial fibrillation, the potential impact of environmental determinants on this prevalent condition has received comparatively less attention. This review aims to provide a comprehensive overview of the current evidence on environmental determinants of atrial fibrillation, encompassing factors such as air pollution, temperature, humidity, and other meteorologic conditions, noise pollution, greenspace, and the social environment. We discuss the existing evidence from epidemiological and mechanistic studies, critically evaluating the strengths and limitations of these investigations and the potential underlying biological mechanisms through which environmental exposures may affect atrial fibrillation risk. Furthermore, we address the potential implications of these findings for public health and clinical practice and identify knowledge gaps and future research directions in this emerging field.

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Mechanisms and Therapeutic Opportunities in Atrial Fibrillation in Relationship to Alcohol Use and Abuse

Cited by 13 publications

References 110 publications

Associated Factors to Atrial Fibrillation in Diabetics at a Peruvian Northern Hospital

Associated Factors to Atrial Fibrillation in Diabetics at a Peruvian Northern Hospital

Single-cell sequencing combined with Bulk RNA-Seq to explore the molecular mechanism of cell communication in atrial fibrillation

Environmental Exposome and Atrial Fibrillation: Emerging Evidence and Future Directions

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