Mechanisms by which the serotonergic system inhibits micturition in rats

Kadekawa, Katsumi; Nishijima, Saori; Sugaya, Kimio; Miyazato, Minoru; Saitoh, Sei–Ichi

doi:10.1016/j.lfs.2009.08.013

Cited by 16 publications

(12 citation statements)

References 30 publications

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“…The serotoninergic pathways in the CNS have been shown to modulate micturition. Electric stimulation of the raphe nucleus, a major 5‐HT‐containing area, causes inhibition of micturition in decerebrated rats (Sugaya et al, ), and intrathecally administered 5‐HT inhibits bladder contractions in rats (Kadekawa et al, ). These lines of evidence suggest that 5‐HT‐containing pathways play an inhibitory role in the control of micturition through the descending pathway from the raphe nucleus to the spinal cord.…”

Section: Discussionmentioning

confidence: 99%

“…These findings suggest that the brain serotoninergic nervous system is a downstream pathway of brain bombesin‐like peptides. The serotoninergic nervous system in the CNS has been reported to modulate micturition, both inhibitory and excitatory (Sugaya et al, ; Ishizuka et al, ; Ramage, ; Kadekawa et al, ; Chiba et al, ). Based on these findings, we hypothesized that brain bombesin‐like peptides can induce frequent urination via modulation of the central serotoninergic nervous system.…”

Section: Introductionmentioning

confidence: 99%

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Brain serotoninergic nervous system is involved in bombesin‐induced frequent urination through brain 5‐HT₇ receptors in rats

Shimizu

Wada

et al. 2017

British J Pharmacology

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Background and Purpose Psychological stress exacerbates symptoms of urinary bladder dysfunction; however, the underlying brain mechanisms are unclear. We have demonstrated that centrally administered bombesin, a stress‐related neuropeptide, facilitates the rat micturition reflex. Brain bombesin‐like peptides modulate the serotoninergic nervous system activity under stress conditions; therefore, we examined whether brain 5‐HT is involved in the bombesin‐induced increased frequency of urination in urethane‐anaesthetised male Sprague–Dawley rats. Experimental Approach Evaluation of intercontraction intervals (ICI) and maximal voiding pressure (MVP) during cystometrograms were started 1 h before i.c.v. administration of bombesin or i.c.v. pretreatment with the 5‐HT receptor antagonists. Key Results Bombesin (0.03 nmol per animal, i.c.v.) significantly reduced ICI without affecting MVP. The bombesin‐induced response was significantly suppressed by acute depletion of brain 5‐HT, which was induced by pretreatment with p‐chlorophenylalanine, a 5‐HT synthesis inhibitor. Bombesin at a lower dose (0.01 nmol per animal, i.c.v.) showed no significant effect on ICI, while it significantly reduced ICI in the presence of WAY‐100635 (5‐HT1A receptor antagonist, 0.1 or 0.3 μg per animal, i.c.v.), which can block the negative feedback control of 5‐HT release. Bombesin (0.03 nmol per animal)‐induced ICI reduction was significantly attenuated by SB269970 (5‐HT7 receptor antagonist, 0.1 or 0.3 μg per animal, i.c.v.) but not by ritanserin (5‐HT2 receptor antagonist, 0.3 or 1 μg per animal, i.c.v.). Conclusions and Implications The brain serotoninergic nervous system is involved in the facilitation of the rat micturition reflex induced by bombesin‐like peptides at least in part through brain 5‐HT7 receptors.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Brain serotoninergic nervous system is involved in bombesin‐induced frequent urination through brain 5‐HT₇ receptors in rats

Shimizu

Wada

et al. 2017

British J Pharmacology

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“…Intrathecal injection of 5-HT abolishes rhythmic bladder contractions and increases urethral baseline pressure in rats [52].…”

Section: Source Of 5-ht In Urinary Bladdermentioning

confidence: 91%

Regulatory Effects of 5-Hydroxytryptamine Receptors on Voiding Function

2015

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“…Naftopidil is also thought to inhibit the micturition reflex by affecting spinal descending neurotransmission . Although intrathecal injection of 5‐HT inhibits bladder contraction, 5‐HT differently modifies glutamate‐ and GABA‐mediated effects, acting on distinct 5‐HT receptor subtypes . 5‐HT2 receptors stimulate GABA release and either increase or reduce glutamate release in distinct structures .…”

Section: Introductionmentioning

confidence: 99%

Action of naftopidil on spinal serotonergic neurotransmission for inhibition of the micturition reflex in rats

Sugaya¹,

Nishijima²,

Kadekawa³

et al. 2016

Neurourology and Urodynamics

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Mechanisms by which the serotonergic system inhibits micturition in rats

Cited by 16 publications

References 30 publications

Brain serotoninergic nervous system is involved in bombesin‐induced frequent urination through brain 5‐HT₇ receptors in rats

Brain serotoninergic nervous system is involved in bombesin‐induced frequent urination through brain 5‐HT₇ receptors in rats

Regulatory Effects of 5-Hydroxytryptamine Receptors on Voiding Function

Action of naftopidil on spinal serotonergic neurotransmission for inhibition of the micturition reflex in rats

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Mechanisms by which the serotonergic system inhibits micturition in rats

Cited by 16 publications

References 30 publications

Brain serotoninergic nervous system is involved in bombesin‐induced frequent urination through brain 5‐HT7 receptors in rats

Brain serotoninergic nervous system is involved in bombesin‐induced frequent urination through brain 5‐HT7 receptors in rats

Regulatory Effects of 5-Hydroxytryptamine Receptors on Voiding Function

Action of naftopidil on spinal serotonergic neurotransmission for inhibition of the micturition reflex in rats

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Brain serotoninergic nervous system is involved in bombesin‐induced frequent urination through brain 5‐HT₇ receptors in rats

Brain serotoninergic nervous system is involved in bombesin‐induced frequent urination through brain 5‐HT₇ receptors in rats