Mechanisms for antidiabetic effect of gingerol in cultured cells and obese diabetic model mice

Son, Myoung Jin; Miura, Yutaka; Yagasaki, Kazumi

doi:10.1007/s10616-014-9730-3

Cited by 80 publications

(73 citation statements)

References 38 publications

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“…More still, [6]-gingerol regulated hepatic gene expression of enzymes related glucose metabolism towards reducing gluconeogenesis and glycogenolysis [3] which is similar to insulin influence as earlier explained. The enhancement of glucose uptake by reconstituted freeze-dried ginger juice was affirmed by Noipha and Ratanachaiyavong [27]. The ginger extract at 400µg/ml markedly increased glucose uptake in L6 myotubes after 20 hours incubation.…”

Section: Introductionsupporting

confidence: 62%

“…Ethyl acetate ginger extract was observed to enhance glucose uptake in cell lines in mice by expressing GLUT4 in cell surface [26]. While [6]-gingerol also exerted similar effect via this mechanism as well as via induction or enhancement of AMPK phosphorylation in L6 myotubes [3]. More still, [6]-gingerol regulated hepatic gene expression of enzymes related glucose metabolism towards reducing gluconeogenesis and glycogenolysis [3] which is similar to insulin influence as earlier explained.…”

Section: Introductionsupporting

confidence: 58%

“…While [6]-gingerol also exerted similar effect via this mechanism as well as via induction or enhancement of AMPK phosphorylation in L6 myotubes [3]. More still, [6]-gingerol regulated hepatic gene expression of enzymes related glucose metabolism towards reducing gluconeogenesis and glycogenolysis [3] which is similar to insulin influence as earlier explained. The enhancement of glucose uptake by reconstituted freeze-dried ginger juice was affirmed by Noipha and Ratanachaiyavong [27].…”

Section: Introductionsupporting

confidence: 55%

“…The ability of [6]-gingerol to regulate the gene expression of enzymes related to glucose metabolism towards decreasing gluconeogenesis and glycogenolysis as reported by which is a similar function of insulin as earlier explained may further ascertain the mimicry of insulin function by ginger. The enhancement of glucose uptake by myotubes of muscles by ethyl acetate ginger extract and gingerol was also observed by Rani et al, [26] and Son et al, [3] in vitro as well as in vivo in obese diabetic mice (3). This marked increase in glucose uptake may be the induction of 5'adenosine monophosphate-activated protein kinase (AMPK) phosphorylation in L6 myotubes and the promotion of glucose transporter 4 (GLUT 4) translocation to cell membrane by [6]-gingerol and ethyl acetate ginger extract [3,26].…”

Section: Effect Of Raw and Cooked Gingermentioning

confidence: 54%

“…Mozaffari-Khosravi et al, [1] reported the blood glucose and glycated hemoglobin lowering effect of daily oral dose of 3g ginger powder in Type 2 diabetic patients while Mahluji et al, [2] reported no change in Fasting Blood Glucose (FBG) and cholesterol in Type 2 diabetic patients after daily oral dose of 2g ginger powder for 2 months. The prominent hypoglycemic component of ginger, [6]-gingerol, was observed to reduce FBG in insulin resistant diabetic obese mice [3] and in streptozotocin (STZ)-induced diabetic albino rats [4].…”

Section: Introductionmentioning

confidence: 99%

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Dietary Ginger Extracts Enhanced Glucose Uptake by Muscle and Adipose of Normal and Diabetic Rats via Mimicry of Insulin Action

Adeniyi¹,

Sanusi²,

Obatolu³

2017

AJBR

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The mechanism for the blood glucose lowering effect of different ginger extracts is yet to be clearly understood, that of raw ginger extracts has been sparsely explored while the mechanism for the cooked ginger extract, the form in which it is mostly consumed, has not been delved into. This study was therefore designed to determine the effect of raw and cooked ginger (Zingiber officinale Roscoe) extracts on glucose uptake by the muscle and adipose of normal, streptozocin-induced and high-fat diet-induced diabetic rats. Fresh ginger rhizomes were washed, peeled, milled and sieved without adding water to obtain the raw extract. A portion of this was boiled for 1 hour to give the cooked extract. Matured male albino rats (140) were divided into two major groups with 70 rats in each group. Group A was further divided into 7 sub-groups (n=10) 40 of which were rendered diabetic with intraperitoneal injection of streptozocin (60mg/kg body weight) to mimic Type 1 diabetes while in Group B Type 2 diabetes was induced with a 12 week consumption of High-Fat Diet (HFD). The remaining 30 rats in each group were left to remain non-diabetic/ normal. Ginger extracts were administered as a daily oral dose for 4 weeks after diabetes induction. The animals were the sacrificed and glucose uptake by the muscle and adipose tissue was determined using standard analytical procedure. Mean data were compared using Least Significant Difference at p≤ 0.05. It was clearly evidenced that both raw and cooked ginger extracts significantly enhanced and increased glucose uptake by the muscle and adipose tissues even in the absence of insulin, hence, mimicking insulin action. Ginger in both raw and cooked forms may therefore be beneficial in the prevention and management of diabetes mellitus. Human trial is hereby recommended. Keywords: raw ginger extract, cooked ginger extract, glucose uptake, diabetes mellitusCite This Article: Adeniyi P.O., Sanusi R.A.,

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Section: Introductionsupporting

confidence: 62%

Section: Introductionsupporting

confidence: 58%

Section: Introductionsupporting

confidence: 55%

Section: Effect Of Raw and Cooked Gingermentioning

confidence: 54%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Dietary Ginger Extracts Enhanced Glucose Uptake by Muscle and Adipose of Normal and Diabetic Rats via Mimicry of Insulin Action

Adeniyi¹,

Sanusi²,

Obatolu³

2017

AJBR

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Promising influences of gingerols against metabolic syndrome: A mechanistic review

2022

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Metabolic syndrome is an inflammatory disorder characterized by diabetes, obesity, atherosclerosis, and hypertension. Globally, this disease is increasing, especially in developed countries. Supposedly, herbal treatments for this disease likely have fewer adverse effects than chemical medications. Thus, they can be suitable options among the available chemical treatments. Ginger has been used as a spice and medicinal plant in traditional medicine and cooking. This herbal compound and its derivatives, such as 6‐gingerol, have shown promising effects on various molecular aspects of metabolic syndrome. In this study, we reviewed and discussed the significant impacts of gingerol, a derivative of ginger, on metabolic syndrome through various mechanisms. The benefits of 6‐gingerol include its effects on AMP‐activated protein kinase (AMPK), which prevent diabetes, lipid regulating effect (peroxisome proliferator‐activated receptors, PPARs), as well as its effects on enzymes and proteins preventing hyperlipidemia caused by a high‐fat diet. In addition, 6‐gingerol has anti‐atherosclerosis and anti‐hypertension effects through several molecular mechanisms. The current review will discuss various effects of 6‐gingerol on molecular pathways involved in diabetes, obesity, atherosclerosis, and hypertension as characterizing features of metabolic syndrome and suggests that 6‐gingerol can be a potential treatment agent for metabolic syndrome and shed light on a higher requirement for more pre‐clinical and clinical investigations.

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[6]‐Gingerol Affects Glucose Metabolism by Dual Regulation via the AMPKα2‐Mediated AS160–Rab5 Pathway and AMPK‐Mediated Insulin Sensitizing Effects

Lee

Kim

Lee

et al. 2015

J of Cellular Biochemistry

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[6]-Gingerol has been used to control diabetes and dyslipidemia; however, its metabolic role is poorly understood. In this study, [6]-gingerol increased adenosine monophosphate (AMP)-activated protein kinase (AMPK) phosphorylation in mouse skeletal muscle C2C12 cells. Stimulation of glucose uptake by [6]-gingerol was dependent on AMPKα2. Moreover, both Inhibition and knockdown of AMPKα2 blocked [6]-gingerol-induced glucose uptake. [6]-Gingerol significantly decreased the activity of protein phosphatase 2A (PP2A). Inhibition of PP2A activity with okadaic acid enhanced the phosphorylation of AMPKα2. Moreover, the interaction between AMPKα2 and PP2A was increased by [6]-gingerol, suggesting that PP2A mediates the effect of [6]-gingerol on AMPK phosphorylation. In addition, [6]-gingerol increased the phosphorylation of Akt-substrate 160 (AS160), which is a Rab GTPase-activating protein. Inhibition of AMPKα2 blocked [6]-gingerol-induced AS160 phosphorylation. [6]-gingerol increased the Rab5, and AMPKα2 knockdown blocked [6]-gingerol-induced expression of Rab5, indicating AMPK play as an upstream of Rab5. It also increased glucose transporter 4 (GLUT4) mRNA and protein expression and stimulated GLUT4 translocation. Furthermore, insulin-mediated glucose uptake and Akt phosphorylation were further potentiated by [6]-gingerol treatment. This potentiation was not observed in the presence of AMPK inhibitor compound C. In summary, our results suggest that [6]-gingerol plays an important role in glucose metabolism via the AMPKα2-mediated AS160-Rab5 pathway and through potentiation of insulin-mediated glucose regulation.

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Mechanisms for antidiabetic effect of gingerol in cultured cells and obese diabetic model mice

Cited by 80 publications

References 38 publications

Dietary Ginger Extracts Enhanced Glucose Uptake by Muscle and Adipose of Normal and Diabetic Rats via Mimicry of Insulin Action

Dietary Ginger Extracts Enhanced Glucose Uptake by Muscle and Adipose of Normal and Diabetic Rats via Mimicry of Insulin Action

Promising influences of gingerols against metabolic syndrome: A mechanistic review

[6]‐Gingerol Affects Glucose Metabolism by Dual Regulation via the AMPKα2‐Mediated AS160–Rab5 Pathway and AMPK‐Mediated Insulin Sensitizing Effects

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