Mechanisms for Hepatoprotective Effects of Hyaluronidase Immobilized by the Nanotechnology Method of Electron-Beam Synthesis

Дыгай, А. М.; Zyuz’kov, G. N.; Zhdanov, V. V.; Удут, Е. В.; Artamonov, A. V.; Bekarev, A. A.; Мадонов, П. Г.; Kinsht, D. N.; Мирошниченко, Л. А.; Khrichkova, T. Yu.; Симанина, Е. В.; Ставрова, Л. А.; Chaikovskiy, A. V.; Markova, T. S.; Minakova, M. Yu.; Гурто, Р. В.

doi:10.1007/s10517-011-1263-6

Cited by 8 publications

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References 5 publications

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“…Оригинальные статьи лекарственные препараты с высокой терапевтической активностью и низкой токсичностью [8]. Результатом такой модификации является возрастание биодоступ ности ИФН, снижение колебаний уровня активного вещества в крови, более длительное сохранение эф фективной концентрации в органах-миш енях, что и повышает эффективность интерферонотерапии [9]. О днако проявление того или иного иммунотропного эффекта в существенной мере зависит от дозовых и временных параметров применения препарата.…”

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DEVELOPMENT OF OPTIMAL EXPERIMENTAL THERAPEUTIC REGIMENS ADMINISTRATION OF IMMOBILIZED INTERFERON α-2b

et al. 2014

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The development of optimal experimental therapeutic schemes of immobilized interferon α-2b (production of JSC «Siberian Center for Pharmacology and Biotechnology», Novosibirsk) administration was conducted in the frame of the common program of pre-clinical study. The drug being studied was administered intragastrically for 3, 5 and 7 days in the therapeutic dose (1.8 × 105 IU/kg). Experimental evaluation of immunotropic properties of immobilized interferon α-2b was carried out at in vivoexperiments in outbred CD1 male mice with using of following tests: the study of drug effect on the phagocytic activity of peritoneal leukocytes (the relative number of phagocytes and the number of bacteria which were assimilated by phagocytes were assessed); the study of drug effect on the humoral immune response (the total number of splenocytes, the relative and absolute number of antibody-forming cells and their functional activity were determined); estimation of drug effect on the cellular immune response with the using of delayed-type hypersensitivity test induced by sheep red blood cells. Based on these data we concluded that course administration of immobilized interferon α-2b in the therapeutic dose for 5 days increased phagocytosis of neutrophils and humoral immune response most effectively. Cell-mediated immune response was significantly increased after 7-fold administration of studied drug.

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DEVELOPMENT OF OPTIMAL EXPERIMENTAL THERAPEUTIC REGIMENS ADMINISTRATION OF IMMOBILIZED INTERFERON α-2b

et al. 2014

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Humoral Mechanisms Regulating the Functions of Progenitor Cells in Chronic Hepatitis

Дыгай¹,

Zyuz’kov²,

Гурто³

et al. 2013

Bull Exp Biol Med

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We studied the secretory function of the liver and bone marrow microenvironment cells under conditions of chronic CCl4-induced hepatitis. Enhanced production of substances stimulating parenchymal tissue-specific precursors and stem cell homing factors by liver cells was observed. In situ binding of stem cells by bone marrow elements increased due to production of various cooperation and adhesion factors against the background of reduced SDF-1 secretion.

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Effect of Pegylated Hyaluronate-Endo-β-N-Acetylhexosaminidase on Humoral Mechanisms Regulating the Functions of Progenitor Cells during Chronic Hepatitis

et al. 2013

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We studied the effect of hyaluronate-endo-β-N-acetylhexosaminidase on the secretory function of the liver and bone marrow microenvironment cells in chronic hepatitis. Enhanced production of substances stimulating parenchymal tissue-specific precursors and stem cell homing factors by liver cells was revealed. At the same time, production of SDF-1 and other chemoattractants and adhesion factors of progenitor cells by bone marrow elements was reduced.

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Mechanisms for Hepatoprotective Effects of Hyaluronidase Immobilized by the Nanotechnology Method of Electron-Beam Synthesis

Cited by 8 publications

References 5 publications

DEVELOPMENT OF OPTIMAL EXPERIMENTAL THERAPEUTIC REGIMENS ADMINISTRATION OF IMMOBILIZED INTERFERON α-2b

DEVELOPMENT OF OPTIMAL EXPERIMENTAL THERAPEUTIC REGIMENS ADMINISTRATION OF IMMOBILIZED INTERFERON α-2b

Humoral Mechanisms Regulating the Functions of Progenitor Cells in Chronic Hepatitis

Effect of Pegylated Hyaluronate-Endo-β-N-Acetylhexosaminidase on Humoral Mechanisms Regulating the Functions of Progenitor Cells during Chronic Hepatitis

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