2003
DOI: 10.1016/j.pharmthera.2003.09.002
|View full text |Cite
|
Sign up to set email alerts
|

Mechanisms involved in the induced differentiation of leukemia cells

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

8
143
0
22

Year Published

2007
2007
2024
2024

Publication Types

Select...
6
1

Relationship

0
7

Authors

Journals

citations
Cited by 147 publications
(173 citation statements)
references
References 306 publications
8
143
0
22
Order By: Relevance
“…The cell line K-562 can be differentiated into various lineages depending of the inducer and has been widely used as a model for leukemia differentiation [19]. Our data revealed that DAC induced a significant number of K-562 cells exhibiting erythroid-like features, such as an induction of both GPA and EpoR expression, and hemoglobin-producing cells.…”
Section: Page 19 Of 59mentioning
confidence: 75%
See 1 more Smart Citation
“…The cell line K-562 can be differentiated into various lineages depending of the inducer and has been widely used as a model for leukemia differentiation [19]. Our data revealed that DAC induced a significant number of K-562 cells exhibiting erythroid-like features, such as an induction of both GPA and EpoR expression, and hemoglobin-producing cells.…”
Section: Page 19 Of 59mentioning
confidence: 75%
“…K-562 can be differentiated into various lineages depending of the inducer and MEG-01 can be differentiated toward the megakaryocytic pathway with several agents [18,19].…”
Section: Dac Treatment Induces Erythroid Differentiation Of K-562 Celmentioning
confidence: 99%
“…6MP and MTX were empirically added to ATRA maintenance in APL based on two nonrandomized studies that suggested that low-dose ALL-type maintenance could decrease the relapse rate, 40,41 and this has been confirmed in recent phase III trials. 19 The potent differentiating activity of low-dose cytotoxic agents in vitro, [16][17][18] together with these clinical results, 19,40,41 suggested to us that 6MP and MTX may be functioning as differentiating agents clinically. We found that the concentrations of 6MP and MTX achieved clinically during maintenance therapy exhibited little direct cytotoxicity against APL and ALL cells in vitro, but nevertheless inhibited APL and ALL clonogenic growth associated with evidence of phenotypic differentiation.…”
Section: Discussionmentioning
confidence: 99%
“…However, APL cells differentiate in response to a variety of unrelated pharmacologic agents that do not signal through RARa, such as vitamin D, 42,43 phorbol esters, 44 bryostatin-1, 15,42 arsenic trioxide 15,45 and even typical cytotoxic anti-cancer agents (Figure 2). 18,46 The activity of such unrelated agents in APL suggests that a specific interaction between ATRA and PML-RARa may not be the total story underlying the sensitivity of APL to differentiation induction. Regardless of the mechanism of action, ATRA's success in APL demonstrates the potential of differentiation therapy to extinguish leukemic progenitors.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation