Mechanisms Linking Obesity, Chronic Kidney Disease, and Fatty Liver Disease

Ix, Joachim H.; Sharma, Kumar

doi:10.1681/asn.2009080820

Cited by 318 publications

(240 citation statements)

References 94 publications

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“…Ix and Sharma (34) concluded that there is a link between obesity, CKD, and nonalcoholic fatty liver disease (NAFLD). Targher et al (35) showed an association between NAFLD and CKD in patients with type 2 DM.…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Epicardial Adipose Tissue and Malnutrition, Inflammation, Atherosclerosis/Calcification Syndrome in ESRD Patients

Türkmen

Kayıkçıoğlu²,

Özbek³

et al. 2011

Clinical Journal of the American Society of Nephrology

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SummaryBackground and objectives Malnutrition, inflammation, atherosclerosis/calcification (MIAC) and endothelial dysfunction are the most commonly encountered risk factors in the pathogenesis of cardiovascular disease in ESRD patients. Epicardial adipose tissue (EAT) is the true visceral fat depot of the heart. The relationship between CAD and EAT was shown in patients with high risk of coronary artery disease. In this study, we aimed to investigate the relationship between EAT and MIAC syndrome in ESRD patients.Design, setting, participants, & measurements Eighty ESRD patients and 27 healthy subjects enrolled in this cross-sectional study. EAT and coronary artery calcification score were measured by a multidetector computed tomography (MDCT) scanner. Patients with serum albumin Ͻ3.5 mg/dl were defined as patients with malnutrition; those with serum C-reactive protein level Ͼ10 ng/dl (normal range, 0 -5 ng/dl) had inflammation; and those with CACS Ͼ10 had atheroscleosis/calcification.Results Total CACS and EAT measurements were significantly higher in ESRD patients when compared with healthy subjects. There was a statistically significant relationship between EAT and CACS in ESRD patients (r ϭ 0.48). EAT measurements were higher in PD patients than HD patients. Twenty-four of the patients had no component, 31 had one component, 17 had two components, and nine had all of the MIAC components. EAT was found to be significantly increased when the presence of MIAC components increased. EAT was positively correlated with age, body mass index, and presence of MIAC. These parameters were also found as independent predictors of increased EAT.Conclusions We found a relationship between EAT and components of MIAC syndrome in ESRD patients.

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Section: Discussionmentioning

confidence: 99%

The Relationship between Epicardial Adipose Tissue and Malnutrition, Inflammation, Atherosclerosis/Calcification Syndrome in ESRD Patients

Türkmen

Kayıkçıoğlu²,

Özbek³

et al. 2011

Clinical Journal of the American Society of Nephrology

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“…Study conducted in pregnant women indicates that fetuin-A concentrations have been positively associated with maternal insulin resistance 14 . Moreover in vitro and in vivo fetuin-A suppresses adiponectin expression which improves insulin resistance and therefore plays a role as an independent determinant of circulating adiponectin in humans 3,12,24 . Higher fetuin-A and lower adiponectin levels may contribute to obesity-induced insulin resistance and development of diabetes 13,24 .…”

Section: The Relationship Between Fetuin-a and Insulin Resistancementioning

confidence: 99%

Fetuin-A (AHSG) and its usefulness in clinical practice. Review of the literature

Dabrowska

Tarach

Wojtysiak-Duma

et al. 2015

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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“…Chronic activation of AMP kinase can result in enhanced mitochondrial biogenesis and oxidative capacity [33]. AD can stimulate glucose utilization and fatty acid oxidation by activating AMP-activated protein kinase [11,34]. Our study demonstrated that CIH partially inhibited the expression of AMPK pathway, whereas AD supplementation could imminently elevate the expression of LKB1 (AMPKK)/AMPK/PGC1-a.…”

Section: Discussionmentioning

confidence: 73%

Adiponectin alleviates genioglossal mitochondrial dysfunction in rats exposed to intermittent hypoxia

2015

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Mechanisms Linking Obesity, Chronic Kidney Disease, and Fatty Liver Disease

Cited by 318 publications

References 94 publications

The Relationship between Epicardial Adipose Tissue and Malnutrition, Inflammation, Atherosclerosis/Calcification Syndrome in ESRD Patients

The Relationship between Epicardial Adipose Tissue and Malnutrition, Inflammation, Atherosclerosis/Calcification Syndrome in ESRD Patients

Fetuin-A (AHSG) and its usefulness in clinical practice. Review of the literature

Adiponectin alleviates genioglossal mitochondrial dysfunction in rats exposed to intermittent hypoxia

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