Mechanisms of 1-hydroxy-2-hydroxymethylanthraquinone from Coptosapelta flavescens as an anti-giardial activity

Hounkong, Kruawan; Sawangjaroen, Nongyao; Kongyen, Wipapan; Rukachaisirikul, Vatcharin; Wootipoom, Natthakul

doi:10.1016/j.actatropica.2015.02.013

Cited by 6 publications

(3 citation statements)

References 24 publications

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“…Alkaloids are naturally occurring nitrogenous chemical molecules with antibacterial potential [19]. This is similar with recent findings in which CF was found to be more efficient than metronidazole against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, E. histolytica, and G. intestinalis [20][21][22].…”

Section: Preliminary Phytochemicalsupporting

confidence: 88%

“…Furthermore, Wipapan Kongyen et al identified four Anthraquinone derivatives and one Naphtoquinone derivative from C. flavescens root acetone extract, 1,4-dimethoxy-2methylanthraquinone (4), 2-amino-. 3-methoxycarbonyl-1,4-naphthoquinone (5), 1hydroxy-2-hydroxymethyl-anthraquinone (6), 1-hydroxy-2-methoxycarbonylanthraquinone (7), and 2-methoxycarbonyl-anthraquinone (8). Simultaneously, antibacterial activity (with Staphylococcus aureus and methicillin-resistant Staphylococcus aureus), dysentery treatment, and cytotoxicity (on kidney cancer cell line -Vero cell) demonstrated that derivative (6) has active Giardiaintestinalis inhibitory activity with a MIC value of 2.5 µg/ml, which was equivalent to that of a positive metronidazole control [9].…”

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confidence: 99%

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Preliminary test and antioxidant activity of the Coptosapelta flavescens Korth’s root extract

Pham

Lê

Nguyen³

et al. 2021

E3S Web Conf.

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The purpose of this study was to examine the phytochemical content and antioxidant activity of Coptosapelta flavescens Korth root extract obtained from various places. Phytochemical screening, antioxidant activity testing using DPPH radical reduction, color reaction (ABTS), iron reduction (FRAP), reduction capacity technique (RP), and total antioxidant capacity (TAC). The phytochemical tests revealed that C. flavescens water and ethanol extract included alkaloids, coumarins, terpenoids, tannins, and flavonoids. The antioxidant activity results revealed that raw material samples gathered directly in the wild in Ninh Son district (Ninh Thuan province, Vietnam) were more effective than those purchased at the local market with EC50 times value. DPPH, ABTS, FRAP, RP, and TAC techniques yielded 56.02 µg/ml, 54.12 µg/ml, 15.9 µg/ml, 44.85 µg/ml, and 110.94 µg/ml, respectively. The antioxidant impact of raw material samples obtained in Bac Ai district (Ninh Son province, Vietnam) was lower but overall better than that of samples gathered at the local market.

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Section: Preliminary Phytochemicalsupporting

confidence: 88%

mentioning

confidence: 99%

Preliminary test and antioxidant activity of the Coptosapelta flavescens Korth’s root extract

Pham

Lê

Nguyen³

et al. 2021

E3S Web Conf.

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show abstract

“…Coptosapelta flavescens Korth, namely Day Khai in Vietnamese, is a precious medicinal herb used by many ethnic groups in Southeast Asian countries to make skin creams, treat worms, colic, and nasal ulcers (Birgitta and Torsten, 2009;Line, 2005), reduce fevers, and defense against infection (Nursanti et al, 2018). C. flavescens extract was previously reported to suppress bacteria more efficiently than metronidazole (Hounkong et al, 2015), treat dysentery or malaria (Kongyen et al, 2014;Arnida et al, 2017Arnida et al, , 2019, reduce blood pressure (Kosala et al, 2017), and exhibit anti-inflammatory activity (Kosala et al, 2018). According to the traditional folk experience from ethnic minorities in central Vietnam, C. flavescens root extract has been used to disinfect wounds, promote skin recovery, treat cold and flu symptoms, and aid in the treatment of gout (Institute of Medicine, 2003;Minh et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Anti-arthritic activity and phytochemical composition of "Cao Khai" (Aqueous extracts of Coptosapelta flavescens Korth.)

Pham

Nguyen²,

Phan³

et al. 2022

Heliyon

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Plant anthraquinones: Classification, distribution, biosynthesis, and regulation

Wang

Jia

Hua

et al. 2023

Journal Cellular Physiology

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Anthraquinones are polycyclic compounds with an unsaturated diketone structure (quinoid moiety). As important secondary metabolites of plants, anthraquinones play an important role in the response of many biological processes and environmental factors. Anthraquinones are common in the human diet and have a variety of biological activities including anticancer, antibacterial, and antioxidant activities that reduce disease risk. The biological activity of anthraquinones depends on the substitution pattern of their hydroxyl groups on the anthraquinone ring structure. However, there is still a lack of systematic summary on the distribution, classification, and biosynthesis of plant anthraquinones. Therefore, this paper systematically reviews the research progress of the distribution, classification, biosynthesis, and regulation of plant anthraquinones. Additionally, we discuss future opportunities in anthraquinone research, including biotechnology, therapeutic products, and dietary anthraquinones.

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Mechanisms of 1-hydroxy-2-hydroxymethylanthraquinone from Coptosapelta flavescens as an anti-giardial activity

Cited by 6 publications

References 24 publications

Preliminary test and antioxidant activity of the Coptosapelta flavescens Korth’s root extract

Preliminary test and antioxidant activity of the Coptosapelta flavescens Korth’s root extract

Anti-arthritic activity and phytochemical composition of "Cao Khai" (Aqueous extracts of Coptosapelta flavescens Korth.)

Plant anthraquinones: Classification, distribution, biosynthesis, and regulation

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