2018
DOI: 10.1039/c8cc05928d
|View full text |Cite
|
Sign up to set email alerts
|

Mechanisms of action of Ru(ii) polypyridyl complexes in living cells upon light irradiation

Abstract: This feature article provides an overview of the most in-depth biological studies on Ru(ii) polypyridyl complexes upon light activation.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
5

Citation Types

0
64
0

Year Published

2019
2019
2024
2024

Publication Types

Select...
8
1

Relationship

6
3

Authors

Journals

citations
Cited by 92 publications
(64 citation statements)
references
References 58 publications
0
64
0
Order By: Relevance
“…As consequence, many efforts have been undertaken to move away from tetrapyrrolic systems, making appealing the exploration of transition metal complexes as potential PDT agents. In this context, ruthenium(II) polypyridyl complexes are attracting much interest due to the rich photoluminescence repertoire, DNA binding ability, redox chemistry, and tunable absorption properties …”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…As consequence, many efforts have been undertaken to move away from tetrapyrrolic systems, making appealing the exploration of transition metal complexes as potential PDT agents. In this context, ruthenium(II) polypyridyl complexes are attracting much interest due to the rich photoluminescence repertoire, DNA binding ability, redox chemistry, and tunable absorption properties …”
Section: Introductionmentioning
confidence: 99%
“…In this context,r uthenium(II) polypyridyl complexes are attracting much interestd ue to the rich photoluminescence repertoire, DNA binding ability,r edox chemistry,and tunable absorption properties. [10][11] In particular,t heir 3 MLCT (metal to ligand charge transfer) state can be easily quenched by molecular oxygen to generate singlet oxygen with good quantumy ields, as in the case of [Ru(bpy) 3 ] 2 + (bpy = 2,2'-bipyridine),t hat showedagreat ability to induce apoptosis of cancer cells in presence of light, althought he scarce selectivity and low DNA binding affinity limited its further application as PDT agent. [12] One of the most important class of anticancer drugs among ruthenium(II) polypyridyl complexes, is represented by DNA intercalators.…”
Section: Introductionmentioning
confidence: 99%
“…Among the new classes investigated, coordinatively saturated, inert Ru(II) polypyridyl complexes are receiving increasing attention due to their promising anticancer and antimicrobial activity as chemotherapeutic agents as well as photodynamic therapy (PDT) photosensitizers (PSs). [6][7][8][9][10][11][12][13][14][15][16][17] Very importantly, one of Mc Farland and co-workers' ruthenium-based PDT PSs, namely TLD-1433, just completed phase I clinical trial as a PDT PS against bladder cancer. [10] In the field of ruthenium-based PDT PSs, most studies in the literature are based on a [Ru(bipy/phen/bphen/dppz)3] 2+ (bipy = 2,2'-bipyridine, phen =1,10-phenanthroline, bphen = 4,7-diphenyl-1,10-phenanthroline, dppz = dipyrido[3,2-a:2′,3′-c]phenazine) scaffold due to their interesting redox properties, long excited-state lifetimes as well as intense luminescence.…”
Section: Introductionmentioning
confidence: 99%
“…Although the use of such compounds as PDT PS against cancer is relatively recent, the results are spectacular with one of such compounds, TLD-1433, having recently completed phase I clinical trial against bladder cancer. [2,[6][7][8][9][10] We note that to reach the therapeutic window for PDT treatment (ca. 600 to 800 nm), some Ru(II) polypyridyl complexes were found to be good PSs for two-photon PDT, [11 -13] further illustrating the versatility of ruthenium in medicinal chemistry.…”
Section: Introductionmentioning
confidence: 99%