Mechanisms of allergen-specific immunotherapy

Głobińska, Anna; Boonpiyathad, Tadech; Satitsuksanoa, Pattraporn; Kleuskens, Mirelle T.A.; Veen, Willem van de; Sokołowska, Milena; Akdiş, Mübeccel

doi:10.1016/j.anai.2018.06.026

Cited by 107 publications

(37 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There is mounting evidence showing that IL-31 is correlated with the itchy pathophysiology of atopic dermatitis, cutaneous T-cell lymphoma, uremic pruritus, allergic contact dermatitis and chronic urticaria [21,22]. In the current study, For t 2-specific IgE, the For t 2 specific IgG1/IgG2a ratio, IL-4, IL-13 and skin inflammation were all reduced following administration of the DNA vaccine, there was also an increase in For t 2-specific IgG2a, as one would expect to see in a successful allergen specific immunotherapy [23,24]. In addition to this, allergen-induced intra-dermal IL-31 production was significantly reduced following the administration of DNA vaccine therapy.…”

Section: Discussionsupporting

confidence: 63%

Therapeutic DNA vaccine attenuates itching and allergic inflammation in mice with established biting midge allergy

et al. 2020

View full text Add to dashboard Cite

Forcipomyia taiwana is a tiny hematophagous midge that attacks en masse. It is responsible for the most prevalent biting insect allergy in Taiwan. For t 2 is its major allergen. The intense itchy reactions can prevent allergic individuals from performing their regular daily outdoor activities. This study aimed to investigate whether the For t 2 DNA vaccine was effective in treating mice with established biting midge allergy. Mice were sensitized with recombinant For t 2 proteins or whole midge extracts. Two to four consecutive shots of various concentrations of For t 2 DNA vaccine, with or without CpG adjuvants, were then administered to midge-sensitized mice. Mice that received two shots of 50-100 μg For t 2 DNA vaccine showed a significant reduction in allergen-induced bouts of scratching, For t 2-specific IgE, specific IgG1/IgG2a ratio in sera, skin eosinophil infiltration, and IL-31 production, as well as IL-4 and IL-13 production by splenocytes. Two doses of For t 2 DNA vaccine one week apart was sufficient to treat mice with established biting midge allergy. The treatment resulted in clinical, immunological, and histopathological improvements. We recommend that this low-cost, convenient treatment strategy be developed for use in humans who are allergic to biting midges.

show abstract

Section: Discussionsupporting

confidence: 63%

Therapeutic DNA vaccine attenuates itching and allergic inflammation in mice with established biting midge allergy

et al. 2020

View full text Add to dashboard Cite

show abstract

“…AIT exposes the allergic individual to small but increasing doses of the allergenic protein, resulting in desensitization or lowered allergen reactivity. The main goal of AIT is to achieve sustained immune unresponsiveness to the food allergen (5,40,41). There are different routes by which AIT can be administered such as SCIT (subcutaneous immunotherapy), SLIT (sublingual immunotherapy), OIT (Oral Immunotherapy), IDIT (intradermal immunotherapy), EPIT (epicutaneous immunotherapy) LNIT (local nasal immunotherapy) and ILIT (intralymphatic immunotherapy) depending on the types of allergens (40,42).…”

Section: Mechanisms Of Allergic Reactions and Current Immunotherapeutmentioning

confidence: 99%

A Comprehensive Review on Natural Bioactive Compounds and Probiotics as Potential Therapeutics in Food Allergy Treatment

et al. 2020

View full text Add to dashboard Cite

“…In fact, AIT induces a protective immunity in allergic patients based on the modification of cellular and humoral responses to the disease causing allergen (7). Besides the inhibition of IgE binding to their specific allergen, the immune deviation from a TH2 to TH1 response, and the decreases in numbers of effector cells in target organs, the generation and maintenance of allergen-specific regulatory T and B cells and the involvement of their suppressive cytokines are essential for the induction of allergen tolerance (8)(9)(10). Beyond doubt the improvement of allergic symptoms is further caused by AIT-induced IgG antibodies found in serum and nasal secretions (8,(11)(12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

Nanobodies—Useful Tools for Allergy Treatment?

2020

View full text Add to dashboard Cite

In the last decade single domain antibodies (nanobodies, V H H) qualified through their unique characteristics have emerged as accepted and even advantageous alternative to conventional antibodies and have shown great potential as diagnostic and therapeutic tools. Currently nanobodies find their main medical application area in the fields of oncology and neurodegenerative diseases. According to late-breaking information, nanobodies specific for coronavirus spikes have been generated these days to test their suitability as useful therapeutics for future outbreaks. Their superior properties such as chemical stability, high affinity to a broad spectrum of epitopes, low immunogenicity, ease of their generation, selection and production proved nanobodies also to be remarkable to investigate their efficacy for passive treatment of type I allergy, an exaggerated immune reaction to foreign antigens with increasing global prevalence.

show abstract

Mechanisms of allergen-specific immunotherapy

Abstract: Although the complex nature of AIT mechanisms is becoming more clear, the need to discover reliable biomarkers to define patients likely to respond to the treatment is emerging.

Cited by 107 publications

References 78 publications

Therapeutic DNA vaccine attenuates itching and allergic inflammation in mice with established biting midge allergy

Therapeutic DNA vaccine attenuates itching and allergic inflammation in mice with established biting midge allergy

A Comprehensive Review on Natural Bioactive Compounds and Probiotics as Potential Therapeutics in Food Allergy Treatment

Nanobodies—Useful Tools for Allergy Treatment?

Contact Info

Product

Resources

About