Mechanisms of cancer metastasis

Castañeda, María; Hollander, Petra den; Kuburich, Nick A.; Rosen, Jeffrey M.; Mani, Sendurai A.

doi:10.1016/j.semcancer.2022.10.006

Cited by 89 publications

(46 citation statements)

References 166 publications

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“…Another relevant characteristic of an anticancer drug is its ability to inhibit angiogenesis, the process of forming new blood vessels from pre-existing ones, as this is crucial for the development and growth of a tumor. An increase in the number of blood vessels in the vicinity of a tumor allows cancer cells to acquire the oxygen and nutrients essential for their development and invade adjacent sites, developing metastases …”

Section: Resultsmentioning

confidence: 99%

“…An increase in the number of blood vessels in the vicinity of a tumor allows cancer cells to acquire the oxygen and nutrients essential for their development and invade adjacent sites, developing metastases. 88 The ex-ovo CAM assay was therefore used to verify the interference of the Cu(II) complexes in angiogenesis. The CAM is an extraembryonic membrane with a high density of blood and lymphatic vessels, serving as a gas exchange surface.…”

Section: Evaluation Of Mitochondrial Membrane Potential (δψ M ) In Hc...mentioning

confidence: 99%

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Copper(II) Complexes with 2,2′:6′,2″-Terpyridine Derivatives Displaying Dimeric Dichloro−μ–Bridged Crystal Structure: Biological Activities from 2D and 3D Tumor Spheroids to In Vivo Models

Choroba,

Machura,

Erfurt

et al. 2024

J. Med. Chem.

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Eight 2,2′:6′,2″-terpyridines, substituted at the 4′position with aromatic groups featuring variations in π-conjugation, ring size, heteroatoms, and methoxy groups, were employed to enhance the antiproliferative potential of [Cu 2 Cl 2 (R-terpy) 2 ]-(PF 6 ) 2 . Assessing the cytotoxicity in A2780 (ovarian carcinoma), HCT116 (colorectal carcinoma), and HCT116DoxR (colorectal carcinoma resistant to doxorubicin) and normal primary fibroblasts revealed that Cu(II) complexes with 4-quinolinyl, 4-methoxy-1naphthyl, 2-furanyl, and 2-pyridynyl substituents showed superior therapeutic potential in HCT116DoxR cells with significantly reduced cytotoxicity in normal fibroblasts (42−129× lower). Besides their cytotoxicity, the Cu(II) complexes are able to increase intracellular ROS and interfere with cell cycle progression, leading to cell death by apoptosis and autophagy. Importantly, they demonstrated antimetastatic and antiangiogenic properties without in vivo toxicity. In accordance with their nuclear accumulation, the Cu(II) complexes are able to cleave pDNA and interact with bovine serum albumin, which is a good indication of their ability for internalization and transport toward tumor cells.

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Section: Resultsmentioning

confidence: 99%

Section: Evaluation Of Mitochondrial Membrane Potential (δψ M ) In Hc...mentioning

confidence: 99%

Copper(II) Complexes with 2,2′:6′,2″-Terpyridine Derivatives Displaying Dimeric Dichloro−μ–Bridged Crystal Structure: Biological Activities from 2D and 3D Tumor Spheroids to In Vivo Models

Choroba,

Machura,

Erfurt

et al. 2024

J. Med. Chem.

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“…6–8 However, the growing knowledge of the metastatic cascade has a significant impact on guiding therapeutic innovation and delivery systems. 5,6,9…”

Section: Introductionmentioning

confidence: 99%

Hydrogels as local depots for on-demand therapeutic delivery: potential therapeutic approaches for tumor metastasis

Andrgie,

Tsai

2024

Mater. Adv.

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“…Metastasis is a multistep continuous process involving a complex series of dynamic events, such as epithelial− mesenchymal transition (EMT), angiogenesis, inflammatory tumor microenvironment initiation, and apoptotic dysfunction. 5 Tumor cells metastasize and spread when EMT occurs in the primary tumor. The early step of EMT is the local infiltration of the surrounding extracellular matrix (ECM) and the stromal cell layer.…”

Section: ■ Introductionmentioning

confidence: 99%

Rhodium(III)–Picolinamide Complexes Act as Anticancer and Antimetastasis Agents via Inducing Apoptosis and Autophagy

Yang

et al. 2023

J. Med. Chem.

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As a continuation of our endeavors in discovering metal-based drugs with cytotoxic and antimetastatic activities, herein, we reported the syntheses of 11 new rhodium(III)–picolinamide complexes and the exploration of their potential anticancer activities. These Rh(III) complexes showed high antiproliferative activity against the tested cancer cell lines in vitro. The mechanism study indicated that Rh1 ([Rh(3a)(CH3CN)Cl2]) and Rh2 ([Rh(3b)(CH3CN)Cl2]) inhibited cell proliferation by multiple modes of action via cell cycle arrest, apoptosis, and autophagy and inhibited cell metastasis via FAK-regulated integrin β1-mediated suppression of EGFR expression. Furthermore, Rh1 and Rh2 significantly inhibited bladder cancer growth and breast cancer metastasis in a xenograft model. These rhodium(III) complexes could be developed as potential anticancer agents with antitumor growth and antimetastasis activity.

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Mechanisms of cancer metastasis

Cited by 89 publications

References 166 publications

Copper(II) Complexes with 2,2′:6′,2″-Terpyridine Derivatives Displaying Dimeric Dichloro−μ–Bridged Crystal Structure: Biological Activities from 2D and 3D Tumor Spheroids to In Vivo Models

Copper(II) Complexes with 2,2′:6′,2″-Terpyridine Derivatives Displaying Dimeric Dichloro−μ–Bridged Crystal Structure: Biological Activities from 2D and 3D Tumor Spheroids to In Vivo Models

Hydrogels as local depots for on-demand therapeutic delivery: potential therapeutic approaches for tumor metastasis

Rhodium(III)–Picolinamide Complexes Act as Anticancer and Antimetastasis Agents via Inducing Apoptosis and Autophagy

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