Mechanisms of cataractogenesis in the presence of magnesium deficiency

Agarwal, Renu; Iezhitsa, Igor Nikolayevich; Agarwal, Puneet; Spasov, A. A.

doi:10.1684/mrh.2013.0336

Cited by 27 publications

(20 citation statements)

References 43 publications

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“…Membrane transport mechanisms utilizing several Mg-dependent ATPases play an important role in maintaining lens homeostasis. Mg supplementation may be of therapeutic value in preventing the onset and progression of cataracts in conditions associated with Mg deficiency [108]. Mg also plays an important role in diminishing the risk of glaucoma by improving ocular blood flow and preventing loss of ganglion cells [109].…”

Section: Resultsmentioning

confidence: 99%

The Importance of Magnesium in Clinical Healthcare

2017

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The scientific literature provides extensive evidence of widespread magnesium deficiency and the potential need for magnesium repletion in diverse medical conditions. Magnesium is an essential element required as a cofactor for over 300 enzymatic reactions and is thus necessary for the biochemical functioning of numerous metabolic pathways. Inadequate magnesium status may impair biochemical processes dependent on sufficiency of this element. Emerging evidence confirms that nearly two-thirds of the population in the western world is not achieving the recommended daily allowance for magnesium, a deficiency problem contributing to various health conditions. This review assesses available medical and scientific literature on health issues related to magnesium. A traditional integrated review format was utilized for this study. Level I evidence supports the use of magnesium in the prevention and treatment of many common health conditions including migraine headache, metabolic syndrome, diabetes, hyperlipidemia, asthma, premenstrual syndrome, preeclampsia, and various cardiac arrhythmias. Magnesium may also be considered for prevention of renal calculi and cataract formation, as an adjunct or treatment for depression, and as a therapeutic intervention for many other health-related disorders. In clinical practice, optimizing magnesium status through diet and supplementation appears to be a safe, useful, and well-documented therapy for several medical conditions.

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Section: Resultsmentioning

confidence: 99%

The Importance of Magnesium in Clinical Healthcare

2017

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“…Ribeiro et al, demonstrated a negative correlation between magnesium and glucose levels as well as between magnesium and oxidative stress [3]. Magnesium deficiency enhances oxidative stress by increased production of free radicals and decreased of antioxidant defenses [53]. In this regard, histological alterations can be due to mildly proinflammatory invasion to renal tissues.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of magnesium on renal function in STZ-induced diabetic rats

Parvizi

Parviz

Tavangar

et al. 2014

J Diabetes Metab Disord

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BackgroundDiabetic nephropathy is a serious complication of T1D (type one diabetes mellitus). Persistent hyperglycemia and subsequent hypomagnesemia is believed to develop kidney damage by activation of oxidative stress. We conducted this study to investigate the renoprotective effect of magnesium sulfate (MgSO4) on renal histopathology and oxidative stress in diabetic rats.MethodsThe study included 70 male rats. The animals were divided into seven groups: control (CRL), control receiving MgSO4 (CRL + Mg1 & CRL + Mg8), diabetic (DM1 & DM8) and diabetic receiving MgSO4 (DM + Mg1 & DM + Mg8). Rats were given 20 mg/kg (i.p) Streptozocin (STZ) for 5 consecutive days in (MLD) multiple low doses to induce T1D. At day 10 treatment groups were received MgSO4 (10 g/l) in drinking water, for 1 or 8 weeks. The blood glucose, BUN and creatinine levels were measured. Renal tissue levels of malondialdehyde (MDA) were measured by thiobarbituric acid (TBA) method to evaluate the oxidative stress. Renal histopathology was done using H & E staining method.ResultsTreatment with MgSO4 significantly decreased the blood glucose in DM + Mg1 and DM + Mg8 groups as compared with DM1 and DM8. Magnesium treatment also decreased serum BUN and tissue level of MDA significantly in both short and long term treatment. The body weight loss and kidney weight to body weight ratio was improved by MgSO4. Histological results showed there were no differences between DM and DM + Mg groups.ConclusionOur findings showed that diabetic nephropathy is associated with high blood glucose level and oxidative stress (significant increase in MDA level). The renal dysfunction and oxidative stress can be improved by magnesium sulfate administration. It is suggested that protection against development of diabetic nephropathy by MgSO4 treatment involves changes in the blood glucose and oxidative stress.

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“…It was previously reported that administration of 200 mg/l magnesium in water delayed progression of cataract in Shumiya cataract rats, a rodent model of human senile cataract [18]. Furthermore, It has been established that rats fed on 30 % galactose diet with oral or topical magnesium taurate showed tendency towards restoration of lens calcium/magnesium ratio and reduced oxidative stress compared to vehicle treated groups [19]. An in vitro anticataract study also showed that addition of magnesium taurate to the medium containing 30 % galactose reduces cataract progression [19].…”

Section: Physicochemical Parameters the Physicochemical Parameters Of Powdered Rhizome Of C Spectabilis Were Determined Based On The Methmentioning

confidence: 97%

“…Furthermore, It has been established that rats fed on 30 % galactose diet with oral or topical magnesium taurate showed tendency towards restoration of lens calcium/magnesium ratio and reduced oxidative stress compared to vehicle treated groups [19]. An in vitro anticataract study also showed that addition of magnesium taurate to the medium containing 30 % galactose reduces cataract progression [19]. The presence of Zinc (24.62 mg/Kg) may also support cataract ameliorative effect of C. spectabilis.…”

Section: Physicochemical Parameters the Physicochemical Parameters Of Powdered Rhizome Of C Spectabilis Were Determined Based On The Methmentioning

confidence: 99%

Pharmacognostic and elemental analysis of the rhizome of C. spectabilis (Fenzl) Schumann (Costaceae)

Sale¹,

Abubakar²,

Danmalam³

et al. 2021

J. Pharm Bio.

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The extract from the rhizome of Costus spectabilis (Costaceae) has been used to treat many illnesses including eye infections and cataract. The present study aimed to establish the pharmacognostic features of the rhizome by evaluating its macro-morphological characteristics, micro-morphological features using its anatomical section, physicochemical constants and elemental profile of its powder according to standard methods. Macro-morphology revealed features typical of a rhizome. Microscopical examination shows vascular bundles scattered throughout the ground tissue of starch-filled cellulosic parenchyma, parenchymatous cortex, endodermis and Oleoresin cells. Chemomicroscopy of the powder showed cellulosic cell walls, lignified cell walls, starch grains, fats and oil. The powder was found to have a moisture content of 12.3%, Total ash of 4.3%, acid insoluble ash of 2.0%, water soluble ash of 1.2%, water soluble extractive of 11.0% and alcohol soluble extractive of 6.5%. Elemental analysis showed the presence of Zn, Cu, Mg, Fe, Pb, Ni, Mn and Cd at concentrations of 24.62, 2.63, 1449.21, 113.23, 36.50, 31.90, 86.93 and 1.23 mg/kg in the powder respectively. The study has established some pharmacognostic features and elemental composition of the rhizome of C. spectabilis. The information could serve useful in providing quality control parameters and standardization of the crude drug. Keywords: Macro-morphology; Microscopical; Physico-chemical; Standardization; Elemental analysis

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Mechanisms of cataractogenesis in the presence of magnesium deficiency

Cited by 27 publications

References 43 publications

The Importance of Magnesium in Clinical Healthcare

The Importance of Magnesium in Clinical Healthcare

Protective effect of magnesium on renal function in STZ-induced diabetic rats

Pharmacognostic and elemental analysis of the rhizome of C. spectabilis (Fenzl) Schumann (Costaceae)

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