Mechanisms of depressed natural killer cell activity in recurrent aphthous ulcers

Sun, Andy; Chu, Chien-Ts; Wu, Yi Chang; Yuan, Joan

doi:10.1016/0090-1229(91)90114-p

Cited by 28 publications

(18 citation statements)

References 24 publications

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“…Natural killer (NK) cells activated by IL‐2 may play a role in the process of this disease. An increased activity of these cells was noted in active lesions, diminishing during periods of remission (Sun et al , 1991). As NK cells are also associated with antiviral activity against varicella zoster virus (VZV) and cytomegalovirus (CMV) (Hayward et al , 1986), a viral antigenic source may be considered for RAS in some patients.…”

Section: Aetiopathogenesismentioning

confidence: 99%

“…CD16+, CD56+ and CD14+) are not altered in RAS . Likewise the function of NK cells in RAS shows no consistent pattern, baseline NK cell function is not notably altered in RAS Ueta et al, 1993), although may be reduced during exacerbation of major RAS, late ulcerative stage of minor RAS (Sun et al, 1991) or indeed during quiescent phases of disease (Sistig et al, 2002).…”

Section: Recurrent Aphthous Stomatitis S Jurge Et Almentioning

confidence: 99%

See 1 more Smart Citation

Number VI Recurrent aphthous stomatitis

et al. 2005

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Recurrent aphthous stomatitis (RAS; aphthae; canker sores) is a common condition which is characterized by multiple recurrent small, round or ovoid ulcers with circumscribed margins, erythematous haloes, and yellow or grey floors typically presenting first in childhood or adolescence. RAS occurs worldwide although it appears most common in the developed world. The aetiology of RAS is not entirely clear. Despite many studies trying to identify a causal microorganism, RAS does not appear to be infectious. A genetic predisposition is present, as shown by strong associations with genotypes of IL-1beta; IL-6 in RAS patients, and a positive family history in about one-third of patients with RAS. Haematinic deficiency is found in up to 20% of patients. Cessation of smoking may precipitate or exacerbate RAS in some cases. Ulcers similar to RAS may be seen in human immunodeficiency virus disease and some other immune defects, and drugs, especially non-steroidal anti-inflammatory drugs and nicorandil may produce lesions clinically similar to RAS. Topical corticosteroids can often control RAS. However, the treatment of RAS remains unsatisfactory, as most therapies only reduce the severity of the ulceration and do not stop recurrence.

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Section: Aetiopathogenesismentioning

confidence: 99%

Section: Recurrent Aphthous Stomatitis S Jurge Et Almentioning

confidence: 99%

Number VI Recurrent aphthous stomatitis

et al. 2005

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“…In RAS, levels of peripheral blood NK cells may be increased (Thomas et al, 1990) or, similar to those of control subjects and NK subsets (e.g., CD16+, CD56+, and CD14+), are not altered in RAS . Likewise, baseline NK cell function is not notably altered in RAS Ueta et al, 1993), although it may be reduced during exacerbation of MaRAS or the late ulcerative stage of MiRAS (Sun et al, 1991).…”

Section: Immunopathogenesismentioning

confidence: 99%