mechanisms of Destruction of Red Cells in Certain Hemolytic Conditions

Ham, Thomas Hale

doi:10.1001/archinte.1956.00250290034006

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1958

2015

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Cited by 8 publications

(1 citation statement)

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“…4 However, it was not until Hamm and Dingle identified that hemolysis was enhanced in the setting of acidic pH, causing an increased red cell sensitivity to the effects of complement, that the underlying mechanism of the disorder emerged. 5,6 In the early 1990's, Rosse and Weidmer described the effect of increasing complement concentration causing platelet vesiculation. 7 During the last 20 years, the pathological defect in PNH, a mutation in the phosphatidylinositol (PI) glycan complementation class A gene (PIG-A), has been identified.…”

Section: Introductionmentioning

confidence: 99%

Paroxysmal nocturnal hemoglobinuria: new concepts in pathophysiology and treatment

Weitz¹

2015

ODRR

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Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematological disorder characterized by hemolysis, cytopenias, bone marrow dysfunction, and thrombosis. Over the last 20 years, we have seen a dramatic unraveling of the pathophysiology of this rare and complex disorder. As a result, new therapies involving complement inhibition have been developed, changing our understanding of the disease and improving outcomes for affected patients.

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Section: Introductionmentioning

confidence: 99%