Serum Enzymes in Disease

Zimmerman, Hyman J.

doi:10.1001/archinte.1958.00260190117013

Cited by 44 publications

(13 citation statements)

References 8 publications

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“…Serum aminotransferase activities are indicative of cellular leakage and loss of functional integrity of cell membranes in liver (Rajesh & Lathe, 2004). Injury to the hepatocytes alters their transport function and membrane permeability, leading to leakage of enzymes from the cells (Zimmerman & Aeeff, 1970). Total protein is measured as a routine test to evaluate the toxicological nature of various chemicals (Nevin & Vijayammal, 2005).…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective effect of ethanol extract fromBerchemia lineateagainst CCl₄-induced acute hepatotoxicity in mice

Liu

Geng

et al. 2014

Pharmaceutical Biology

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Objective: The present study investigates the hepatoprotective effect of Berchemia lineate ethanol extract (BELE) on CCl 4 -induced acute liver damage in mice. Materials and methods: Effect of BELE administrated for 7 consecutive days was evaluated in mice by the serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total bilirubin (TBIL), albulin (ALB), globulin (GLB), and total protein (TP) levels, as well as liver superoxide dismutase (SOD) activity and malondialdehyde (MDA) level. Moreover, histopathological examinations were also taken. SOD (291.17, 310.32, and 325.67 U/mg prot) and reduction of MDA (7.27, 6.77, and 5.33 nmol/mg prot) levels. Histopathological examinations also confirmed that BELE can ameliorate CCl 4 -induced liver injuries, characterized by extensive hepatocellular degeneration/necrosis, inflammatory cell infiltration, congestion, and sinusoidal dilatation. Discussion and conclusion: The results indicated that BELE possessed remarkable protective effect against acute hepatotoxicity and oxidative injuries induced by CCl 4 , and that the hepatoprotective effects of BELE may be due to both the inhibition of lipid peroxidation and the increase of antioxidant activity.

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Section: Discussionmentioning

confidence: 99%

Hepatoprotective effect of ethanol extract fromBerchemia lineateagainst CCl₄-induced acute hepatotoxicity in mice

Liu

Geng

et al. 2014

Pharmaceutical Biology

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“…Serum aminotransferase activities have long been considered as sensitive indicators of hepatic injury (Molander et al, 1955). Injury to the hepatocytes alters their transport function and membrane permeability, leading to leakage of enzymes from the cells (Zimmerman & Seeff, 1970). Therefore, the marked release of AST and ALT into the circulation indicates severe damage to hepatic tissue membranes during CCl 4 intoxication.…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective effects of Juglans regia extract against CCl₄-induced oxidative damage in rats

Eidi

Moghadam

Mortazavi

et al. 2013

Pharmaceutical Biology

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Context: Different parts of the walnut [Juglans regia L. (Juglandaceae)] have been used in folk medicine for protection against liver injury, although its actual efficacy remains uncertain. Objective: The present study investigated the protective effect of walnut leaf extract against carbon tetrachloride (CCl 4 )-induced liver damage in rats. Materials and methods: The rats were randomly divided into seven groups: control, CCl 4 (i.p., 0.5 mL/kg b.w., 50% CCl 4 in olive oil), walnut extract (at dose level of 0.2 g/kg b.w.) alone, walnut extract (at dose levels of 0.05, 0.1, 0.2 and 0.4 g/kg b.w.) with CCl 4 , and treatment was carried out accordingly. On the 28th day, rats were sacrificed and blood was withdrawn by cardiac puncture. Liver damage was assessed by serum biochemical parameters (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and albumin), antioxidant enzymes (superoxide dismutase and catalase) and histopathological observation. Results: Administration of walnut leaf extract (ranging from 0.2 to 0.4 g/kg b.w.) significantly lowered serum alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase levels in CCl 4 -treated rats. Walnut leaf extract increased antioxidant enzymes, including superoxide dismutase and catalase. Histopathological examination of livers showed that walnut leaves extract reduced fatty degeneration, cytoplasmic vacuolization and necrosis in CCl 4 -treated rats. Discussion and conclusion: These results suggest that walnut extract has a protective effect over CCl 4 -induced oxidative damage in rat liver. These results demonstrate that walnut extract acts as a good hepatoprotective and antioxidant agent in attenuating hepatocellular damage.

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“…The elevated levels of serum enzymes are indicative of cellular leakage and loss of functional integrity of cell membrane in liver (Zimmerman & Seeff, 1970). Thus, lowering of enzyme content in serum is a definite indication of hepatoprotective action of a drug.…”

Section: Discussionmentioning

confidence: 99%

Effect of flavonoids fromProsthechea michuacanaon carbon tetrachloride induced acute hepatotoxicity in mice

Gutierrez

Sosa

Hoyo‐Vadillo

et al. 2011

Pharmaceutical Biology

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Serum Enzymes in Disease

Cited by 44 publications

References 8 publications

Hepatoprotective effect of ethanol extract fromBerchemia lineateagainst CCl₄-induced acute hepatotoxicity in mice

Hepatoprotective effect of ethanol extract fromBerchemia lineateagainst CCl₄-induced acute hepatotoxicity in mice

Hepatoprotective effects of Juglans regia extract against CCl₄-induced oxidative damage in rats

Effect of flavonoids fromProsthechea michuacanaon carbon tetrachloride induced acute hepatotoxicity in mice

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Serum Enzymes in Disease

Cited by 44 publications

References 8 publications

Hepatoprotective effect of ethanol extract fromBerchemia lineateagainst CCl4-induced acute hepatotoxicity in mice

Hepatoprotective effect of ethanol extract fromBerchemia lineateagainst CCl4-induced acute hepatotoxicity in mice

Hepatoprotective effects of Juglans regia extract against CCl4-induced oxidative damage in rats

Effect of flavonoids fromProsthechea michuacanaon carbon tetrachloride induced acute hepatotoxicity in mice

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Hepatoprotective effect of ethanol extract fromBerchemia lineateagainst CCl₄-induced acute hepatotoxicity in mice

Hepatoprotective effect of ethanol extract fromBerchemia lineateagainst CCl₄-induced acute hepatotoxicity in mice

Hepatoprotective effects of Juglans regia extract against CCl₄-induced oxidative damage in rats