Effect of flavonoids from<i>Prosthechea michuacana</i>on carbon tetrachloride induced acute hepatotoxicity in mice

Gutierrez, Rosa Martha Pérez; Sosa, Irasema Anaya; Hoyo‐Vadillo, Carlos; Victoria, Teresa Cruz

doi:10.3109/13880209.2011.570766

Cited by 24 publications

(18 citation statements)

References 16 publications

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“…When the measurement of the total antioxidant status of serum and liver concentrations were estimated of rat groups, the results appeared that the total antioxidant status in serum had no significant variation in comparison with liver that appeared a significant variation (p˂0.05) between DMBA and DMBA+PDE groups compared with control group of liver antioxidants (Fig. 6) that indicate the amount of free radicals in liver rats of DMBA reference group were higher than DMBA+PDE group, as a result of inhibiting of antioxidant enzyme activities by DMBA carcinogen, and these results were in agreement with the previous studies [85,86].…”

Section: Animal Experimentssupporting

confidence: 91%

“…Phenolics and flavonoids such as ginestin and quercetin have protective effects in estrogen-dependent breast cancer by binding to estrogen receptor and modulating estrogen metabolism by selective inhibition of CYP1B1 activities without affecting CYP1A1 or CYP1A2 [81]. Since flavonoids inhibit DNA binding, they have antimutagenic, anticlastogenic, antitumor, and anticarcinogenesis effects [82][83][84][85]. The above results were in agreement with previous studied that documented that the DMBA carcinogen induced leukemia in rats by its effects as a mini -nucleus and induces single-and double-strand breaks in nuclear and mitochondrial DNA [72].…”

Section: Animal Experimentsmentioning

confidence: 99%

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Preventive Effects of Phoenix Dactylifera Polyphenols Against 7,12-Dimethylbenz(a)anthracene-Induced Mammary Cancer

Omran

Al-taee

Hashim

et al. 2017

Asian J Pharm Clin Res

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Objectives: Polyphenols are vital micronutrients, in our diet, which have a role in the prevention of progressive cancer and cardiovascular diseases developing. The main objective of this research was to evaluate the hemopreventive effects of some polyphenols of Phoenix dactylifera pits on 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary cancer of female albino rats.Methods: The phenolics of P. dactylifera pits (Zahidi cultivar) were prepared by successive steps; extraction by ethanol:methanol:HCl:H2O, adsorption chromatography using a silica gel column and preparative high performers chromatography. The cytotoxic activity of the phenolics was detected against human breast cancer cell line (MCF-7). The acetone phenolic fraction, 50 female albino rats, and DMBA carcinogen were used to study the preventive effects.Results: The acetone phenolic fraction contained considerable amounts of the total phenolics and having antioxidant activity, which inhibit cancer cell line MCF-7 growth, and the inhibitory concentration 50% of cells (IC50) at 24 hrs was 202 μg/ml for MCF-7 and 480 μg/ml for WRL-68. The purified phenolic compounds may be related to genistein and quercetin derivatives that inhibited MCF-7 cell line growth and IC50 were 1030 and 203.9 μg/ml, respectively, compared with negligible effects on normal cell line. The acetone phenolic fraction prevented mammary cancer formation in the DMBA-induced rat model.Conclusions: The phenolics of date palm had chemopreventive effects against DMBA-induced mammary cancer, and they required further research to clarify the possible mechanisms that might have contributed to the preventive effects against mammary cancer.

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Section: Animal Experimentssupporting

confidence: 91%

Section: Animal Experimentsmentioning

confidence: 99%

Preventive Effects of Phoenix Dactylifera Polyphenols Against 7,12-Dimethylbenz(a)anthracene-Induced Mammary Cancer

Omran

Al-taee

Hashim

et al. 2017

Asian J Pharm Clin Res

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“…It also exerts anti-diabetic effect through enhanced adiponectin secretion, phosphorylation of insulin receptor-β, and GLUT4 translocation (Yokozawa et al, 1999). Furthermore, its hepatoprotective effect was reported against carbon tetrachloride induce hepatotoxicity in mice (Perez Gutierrez et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory Effect of Apigenin-7-neohesperidoside (Rhoifolin) in Carrageenin-Induced Rat Oedema Model

Eldahshan¹

2012

J. App. Pharm. Sci.

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Flavonoids are normal constituents of the human diet and are known for a variety of biological activities. They have been reported to bring benefits in lowering inflammation and oxidative stress. The present investigation was performed first, to evaluate the anti-inflammatory activity of rhoifolin and second, to search for the possible contributing mechanisms for this hypothesized effect. Rhoifolin caused a time and reverse dose dependent reduction of carrageenin-induced rat paw oedema. Following 4 hr of treatment, rhoifolin at doses 2.5, 25 & 250 mg/kg caused a significant inhibition of rat paw edema volume by 14, 25 & 45 % respectively in comparison to the control group (74%). In addition to significantly abrogating prostaglandin E2 level, increasing doses of rhoifolin significantly diminished the TNF-α release in the inflammatory exudates. In the same animal model, rhoifolin increased the total antioxidant capacity in a reverse dose order, with the highest capacity obtained with the lowest dose tested. This study demonstrates for the first time the effectiveness of rhoifolin in combating inflammation in carrageenin-induced rat oedema model.

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“…This radical reacts with cellular molecules (nucleic acid, protein, lipid) and impairing crucial cellular processes [5]. In the presence of oxygen, CCl 3 • is converted to the more reactive trichloromethylperoxy radical (CCl 3 OO • ). CCl 3 OO…”

Section: Discussionmentioning

confidence: 99%

“…Plants are used in traditional medicine for the treatment of liver disorders, as they may serve as potential sources for new therapeutic agents that could be applied in the prevention of hepatic injuries. Plants, rich in different phytochemical derivatives such as triterpenes, flavonoids or polyphenols, have been reported to exhibit antihepatotoxic effects on experimental liver injury models [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

Protective effect of Amaranthus lividus L. on carbon tetrachloride induced hepatotoxicity in rats

Yilmaz-Ozden

2015

Turk J Bioch

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March 5, 2015] and evaporated to dryness under reduced pressure in a rotary evaporator (Buchi R210, Switzerland). The water extract of A. lividus was yielded a dark-brown solid residue, weighing 26 g (26%, w/w) which was stored at -20 o C. A. lividus is generally cooked with water before being consumed, for this reason water extract of A. lividus was used in this study. AnimalsMale albino Wistar rats (180-280 g) were obtained from the Institute of Experimental Medicine of Istanbul University and acclimatized to their environment for one week prior to experimentation. The animals were housed in an air-conditioned room with a 12 h light/dark cycle at controlled temperature and humidity conditions and supplied with standard laboratory diet and tap water ad libitum. The experimental procedure used in this study was approved by the Animal Assays Ethics Committee of Istanbul University (No:18527/16.07.2007). TreatmentsThe water extracts of A. lividus at 250 and 500 mg/kg [9] and the standard hepatoprotective drug silymarin (25 mg/ kg) [10] were administered orally as a fine suspension in carboxymethyl cellulose (CMC, 0.1%, w/v). These solutions were freshly prepared at each day of process. Liver damage was induced by intraperitoneal (i.p.) administration of a single dose of an equal mixture of CCl 4 and olive oil (1.5 mL/kg) [11]. The CCl 4 mixture was prepared immediately before treatment.Male albino Wistar rats were randomly divided into 7 groups. Group I, II and III served as control groups (n=5) which received orally CMC (4 mL/kg), A. lividus (500 mg/kg) and silymarin (25 mg/kg), respectively, daily for 9 days. Group IV, V, VI and VII served as experimental groups (n=7) which received orally CMC (4 mL/kg), A. lividus (250 mg/kg), A. lividus (500 mg/kg) and silymarin (25 mg/kg), respectively, daily for 9 days. On the 10th day, rats in the experimental groups (IV-VII) were treated with CCl 4 (1.5 mL/kg, 1:1 in olive oil, i.p.) while rats in the control groups (I-III) were treated with olive oil (1.5 mL/kg, i.p.). 24 h after CCl 4 administration, the animals were anesthetized with diethyl ether and sacrificed by collecting blood via cardiac puncture. Blood was allowed to coagulate for 30 min and serum was separated by centrifugation at 1,016 x g for 5 min at 4 o C. Serum was kept at -85 o C until it was used in further biochemical assays. Livers were quickly excised and washed in 0.9% NaCl to remove as much blood as possible and then tissue samples were immediately frozen at -85 o C for later use. The right upper lobe of the liver of each animal was used for the biochemical and histopathological analysis. Serum biochemical assayAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities were assayed in the serum

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Effect of flavonoids fromProsthechea michuacanaon carbon tetrachloride induced acute hepatotoxicity in mice

Cited by 24 publications

References 16 publications

Preventive Effects of Phoenix Dactylifera Polyphenols Against 7,12-Dimethylbenz(a)anthracene-Induced Mammary Cancer

Preventive Effects of Phoenix Dactylifera Polyphenols Against 7,12-Dimethylbenz(a)anthracene-Induced Mammary Cancer

Anti-inflammatory Effect of Apigenin-7-neohesperidoside (Rhoifolin) in Carrageenin-Induced Rat Oedema Model

Protective effect of Amaranthus lividus L. on carbon tetrachloride induced hepatotoxicity in rats

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