Mechanisms of endothelial dysfunction during aging: Predisposition to thrombosis

Sepúlveda, César; Palomo, Iván; Fuentes, Eduardo

doi:10.1016/j.mad.2017.04.011

Cited by 58 publications

(41 citation statements)

References 93 publications

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“…The distinct features of the two conditions caused inevitable biases in the age of the two groups. Aging has been reported to be associated with endothelial dysfunction [22]. For instance, the study by Yavuz et al [23] reported that endothelial function declines with an increase in the age of healthy human subjects.…”

Section: Discussionmentioning

confidence: 99%

Decreased angiogenic and increased apoptotic activities of bone microvascular endothelial cells in patients with glucocorticoid-induced osteonecrosis of the femoral head

Liu

Zuo

et al. 2020

BMC Musculoskelet Disord

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Background: Glucocorticoid-induced osteonecrosis of the femoral head (ONFH) is closely associated with the dysfunction of the bone microvascular endothelial cells (BMECs). The present study investigated the angiogenic and apoptotic activity of the BMECs in glucocorticoid-induced ONFH. Methods: This study enrolled a total of 12 patients, six of whom were assigned to the ONFH group whereas the other six served as the control group. The ONFH group was composed of patients with glucocorticoid-induced ONFH while the control group had femoral neck fractures. BMECs were isolated from the subchondral region of the femoral head. Cell proliferation, cell viability, tube formation assay, Transwell assay, TUNEL assay, and Western blot analysis were performed.Results: BMECs of the two groups were successfully isolated and identified. No significant differences were noticed in BMECs proliferation between the two groups. However, compared to the control, cell viability, tube formation, and migration of BMECs were significantly decreased and the number of TUNEL positive cells was markedly increased in the ONFH group. In the ONFH group, it was also noted that the amount of Bax and cleaved-caspase3 was elevated while that of Bcl-2 was reduced. Conclusion:The findings of our study revealed that BMECs obtained from the glucocorticoid-induced ONFH patients had decreased angiogenic and increased apoptotic activities, which could explain the pathogenesis and progression of glucocorticoid-induced ONFH.

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Section: Discussionmentioning

confidence: 99%

Decreased angiogenic and increased apoptotic activities of bone microvascular endothelial cells in patients with glucocorticoid-induced osteonecrosis of the femoral head

Liu

Zuo

et al. 2020

BMC Musculoskelet Disord

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“…These include alterations in the metabolism of nitric oxide and prostanoides, endothelin-1, thrombomodulin, and VWF. These alterations potentiate the procoagulant status developed with aging, highlighting the endothelial role in the development of thrombosis in aging [153]. It was demonstrated that sirtuins SIRT1, SIRT3, and SIRT6 can protect ECs against vascular aging [151].…”

Section: Endothelial Cell Senescence and Endothelial-mesenchymal Tranmentioning

confidence: 99%

Markers and Biomarkers of Endothelium: When Something Is Rotten in the State

Гончаров

Nadeev

Jenkins

et al. 2017

Oxidative Medicine and Cellular Longevity

165

115

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Endothelium is a community of endothelial cells (ECs), which line the blood and lymphatic vessels, thus forming an interface between the tissues and the blood or lympha. This strategic position of endothelium infers its indispensable functional role in controlling vasoregulation, haemostasis, and inflammation. The state of endothelium is simultaneously the cause and effect of many diseases, and this is coupled with modifications of endothelial phenotype represented by markers and with biochemical profile of blood represented by biomarkers. In this paper, we briefly review data on the functional role of endothelium, give definitions of endothelial markers and biomarkers, touch on the methodological approaches for revealing biomarkers, present an implicit role of endothelium in some toxicological mechanistic studies, and survey the role of reactive oxygen species (ROS) in modulation of endothelial status.

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“…On the other hand, ET-1 expression is also increased with aging; ET-1 inhibits acetylcholine (ACh)-dependent platelet inhibition in the endothelium and is a promoter of vWF expression. vWF is negative regulator of NO and a well-known marker of ED [49]. More recently, Medin, a common amyloidogenic protein in humans, especially in older individuals, has been shown to induce ED.…”

Section: Biology Of the Endothelium And Endothelial Dysfunctionmentioning

confidence: 99%

Role of free fatty acids in endothelial dysfunction

et al. 2017

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Plasma free fatty acids levels are increased in subjects with obesity and type 2 diabetes, playing detrimental roles in the pathogenesis of atherosclerosis and cardiovascular diseases. Increasing evidence showing that dysfunction of the vascular endothelium, the inner lining of the blood vessels, is the key player in the pathogenesis of atherosclerosis. In this review, we aimed to summarize the roles and the underlying mechanisms using the evidence collected from clinical and experimental studies about free fatty acid-mediated endothelial dysfunction. Because of the multifaceted roles of plasma free fatty acids in mediating endothelial dysfunction, elevated free fatty acid level is now considered as an important link in the onset of endothelial dysfunction due to metabolic syndromes such as diabetes and obesity. Free fatty acid-mediated endothelial dysfunction involves several mechanisms including impaired insulin signaling and nitric oxide production, oxidative stress, inflammation and the activation of the renin-angiotensin system and apoptosis in the endothelial cells. Therefore, targeting the signaling pathways involved in free fatty acid-induced endothelial dysfunction could serve as a preventive approach to protect against the occurrence of endothelial dysfunction and the subsequent complications such as atherosclerosis.

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Mechanisms of endothelial dysfunction during aging: Predisposition to thrombosis

Cited by 58 publications

References 93 publications

Decreased angiogenic and increased apoptotic activities of bone microvascular endothelial cells in patients with glucocorticoid-induced osteonecrosis of the femoral head

Decreased angiogenic and increased apoptotic activities of bone microvascular endothelial cells in patients with glucocorticoid-induced osteonecrosis of the femoral head

Markers and Biomarkers of Endothelium: When Something Is Rotten in the State

Role of free fatty acids in endothelial dysfunction

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