Mechanisms of energy dissipation and relationship with tissue composition in human meniscus

Morejon, Andy; Mantero, Alejandro.M.A.; Best, Thomas M.; Jackson, Alicia R.; Travascio, Francesco

doi:10.1016/j.joca.2022.01.001

Cited by 14 publications

(15 citation statements)

References 33 publications

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“…Further studies to investigate the potential regional variations (i.e. central vs horns, vascular vs avascular) are required to gain a more comprehensive understanding of the diffusive properties of the meniscus given its reported homogeneity of mechanical and transport properties [ 36 , 38 , 48 , [57] , [58] , [59] , [60] , [61] ]. Finally, this study investigated solute partitioning at room temperature (∼23 °C), while previous studies have shown that diffusion and solubility in cartilaginous tissues depends on temperature [ 20 , 62 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of molecular weight and tissue layer on solute partitioning in the knee meniscus

Morejon¹,

Schwartz²,

Best³

et al. 2023

Osteoarthritis and Cartilage Open

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Section: Discussionmentioning

confidence: 99%

Effect of molecular weight and tissue layer on solute partitioning in the knee meniscus

Morejon¹,

Schwartz²,

Best³

et al. 2023

Osteoarthritis and Cartilage Open

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“…[58] Energy dissipation can be calculated by determining the area between the loading and unloading curves. [59,60] DMA: DMA was performed on a DMA tester (TA Instruments, Q800, New Castle, DE, USA) to examine the macroscopic energy dissipation within distinct zones. After applying stresses to the cartilage, the freezing microtome was used to excise the ED surface and ED interspace immediately and then performed uniaxial compressive stress-strain tests, respectively.…”

Section: Methodsmentioning

confidence: 99%

“…[ 58 ] Energy dissipation can be calculated by determining the area between the loading and unloading curves. [ 59,60 ]…”

Section: Methodsmentioning

confidence: 99%

Spatial Heterogeneity Directs Energy Dissipation in Condylar Fibrocartilage

Jiang

Sun

et al. 2023

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Condylar fibrocartilage with structural and compositional heterogeneity can efficiently orchestrate load‐bearing and energy dissipation, making the temporomandibular joint (TMJ) survive high occlusion loads for a prolonged lifetime. How the thin condylar fibrocartilage can achieve efficient energy dissipation to cushion enormous stresses remains an open question in biology and tissue engineering. Here, three distinct zones in the condylar fibrocartilage are identified by analyzing the components and structure from the macro‐and microscale to the nanoscale. Specific proteins are highly expressed in each zone related to its mechanics. The heterogeneity of condylar fibrocartilage can direct energy dissipation through the nano‐micron–macro gradient spatial scale, by atomic force microscope (AFM), nanoindentation, dynamic mechanical analyzer assay (DMA), and the corresponding energy dissipation mechanisms are exclusive for each distinct zone. This study reveals the significance of the heterogeneity of condylar fibrocartilage in mechanical behavior and provides new insights into the research methods for cartilage biomechanics and the design of energy‐dissipative materials.

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“…Reproduced from Zhang et al Surgical induction. Surgical induction methods for OA generation in animals mainly include anterior cruciate ligament transection (ACLT), ovariectomy (OVX), meniscus instability, collateral ligament transection, local cartilage injury, etc., 71 as shown in Figure 3(A). 72 OA was generated in rabbits through ACLT, which destroyed the cellular physiology and cartilage structure of rabbit cartilage, resulting in joint imbalance and ligament transection.…”

Section: Generation Of Animal Oa Modelsmentioning

confidence: 97%

Osteoarthritis models: From animals to tissue engineering

Dou

Wang

et al. 2023

J Tissue Eng

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Osteoarthritis (OA) is a chronic degenerative osteoarthropathy. Although it has been revealed that a variety of factors can cause or aggravate the symptoms of OA, the pathogenic mechanisms of OA remain unknown. Reliable OA models that accurately reflect human OA disease are crucial for studies on the pathogenic mechanism of OA and therapeutic drug evaluation. This review first demonstrated the importance of OA models by briefly introducing the OA pathological features and the current limitations in the pathogenesis and treatment of OA. Then, it mainly discusses the development of different OA models, including animal and engineered models, highlighting their advantages and disadvantages from the perspective of pathogenesis and pathology analysis. In particular, the state-of-the-art engineered models and their potential were emphasized, as they may represent the future direction in the development of OA models. Finally, the challenges in obtaining reliable OA models are also discussed, and possible future directions are outlined to shed some light on this area.

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Mechanisms of energy dissipation and relationship with tissue composition in human meniscus

Cited by 14 publications

References 33 publications

Effect of molecular weight and tissue layer on solute partitioning in the knee meniscus

Effect of molecular weight and tissue layer on solute partitioning in the knee meniscus

Spatial Heterogeneity Directs Energy Dissipation in Condylar Fibrocartilage

Osteoarthritis models: From animals to tissue engineering

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