Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.

Payot, Sophie; Bolla, Jean‐Michel; Corcoran, Deborah; Fanning, Séamus; Mégraud, Françis; Zhang, Qijing

doi:10.1016/j.micinf.2005.12.032

Cited by 175 publications

(164 citation statements)

References 40 publications

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“…This observation is in accordance with the published literature (Payot, S et al, 2006 pigs, this finding may reflect the chemotherapeutic choice made by veterinary practitioners in managing infections in these food-producing animals.…”

Section: Isolates From Animalssupporting

confidence: 92%

Joint Opinion on antimicrobial resistance (AMR) focused on zoonotic infections

2009

EFSA Journal

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Section: Isolates From Animalssupporting

confidence: 92%

Joint Opinion on antimicrobial resistance (AMR) focused on zoonotic infections

2009

EFSA Journal

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“…The results strengthened the evidence of antibacterial potential of these plants [18,17]. These variations in the antibacterial activity of the plant extracts in different solvents is dependent on the different chemical nature of the solvents [26,36].…”

Section: Resultssupporting

confidence: 73%

“…antimicrobials has amplified during the 1990s [9,35,36]. Increasing antimicrobial resistance has complicated the empirical treatment of Camypylobacter infections in countries where fluoroquinolone-resistant strains predominate.…”

Section: Resultsmentioning

confidence: 99%

Anti Campylobacter Activity of Extracts of Daphne Mucronata and Symplocos Racemosa Against Avian Isolates

Yahya¹,

Kazmi²

2017

Natl. j. health sci.

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Bacterial gastroenteritis mainly caused by Campylobacter sp. is a major health concern in Pakistan. In order to investigate the primary sources of Campylobacter infection, total 81 cloacal swab samples were collected from different avian species in Karachi. Campylobacter strains were isolated, identified and antibiotic susceptibility pattern was studied. All isolates of Campylobacter were sensitive to Gentamicin and Ofloxacin. It was observed that 23% of the C. jejuni positive isolates were resilient to tetracycline, 45% to ampicillin, and 12% to erythromycin. The Campylobacter isolates showed susceptibility to the extracts of two plants namely Daphne Mucronata and Symplocos racemosa. The sensitivity of the isolates towards these extracts can be an alternative to the traditional antibiotics for the treatment of Campylobacter infections.

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“…On the other hand, in case of C. coli strains (n =16), 100% isolates were resistant to nalidixic acid (MIC, 32-128 µg/ml), ciprofloxacin (MIC, 4-128 µg/ml) and sulfamethoxazole-trimethoprim whereas 93.75% isolates were resistant to levofloxacin (MIC, 2-16 µg/ml) and ofloxacin (MIC, 4-32 µg/ml) followed by 62.5% were resistant to ampicillin (MIC, 16-32 µg/ml) and 43.75% were resistant to tetracycline (MIC, 128 µg/ml ) and one C. coli strains had the Thr 86 to Ile and Met 181 to Arg substitution in GyrA and the rest 15 strains had only Thr 86 to Ile substitution in GyrA (Table 6). For Campylobacter strains, high-level resistance to fluoroquinolones is mostly mediated by mutations within the QRDR of the gyrA gene, of which replacement of C256 with T leading to a Thr-86-Ile substitution in GyrA is predominant (Ge et al, 2003;Vacher et al, 2003;Payot et al, 2006;Bakeli et al, 2008).…”

Section: Resultsmentioning

confidence: 99%

Molecular identification and antimicrobial resistance profiles of Campylobacter strains of poultry origin in India with special emphasis on fluoroquinolone resistance

Kabir

Asakura

Shiramaru

et al. 2015

Asian J. Med. Biol. Res

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Abstract:The current study aimed to identify the selected number of Campylobacter strains of poultry origin in India that were isolated in the Laboratory of International Prevention of Epidemics, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Japan to the species level with the aid of cdtA/B/C gene-based multiplex PCR assays as well as to investigate their antimicrobial resistance profiles. C. jejuni (4 strains) and C. coli (16 strains) were identified. The poultry isolates identified were subjected to susceptibility testing with the aid of disk diffusion method using 12 antimicrobial agents. Again, the resistant and intermediate isolates confirmed by the disk diffusion method were subjected to determination of minimum inhibitory concentration by agar dilution method. To elucidate the mechanism of quinolone resistance, a total number of 20 quinolone resistant strains were subjected to sequence determination and analysis of the gyrA gene in the quinolone-resistance determining region. The results of the disk diffusion method were consistent with the results of the agar dilution method with slight variation in case of ampicillin, levofloxacin, ofloxacin and fosfomycin. All C. jejuni and C. coli strains had the Thr 86 to Ile substitution in gyrA. Results of this study support the emergence of resistance of C. jejuni and C. coli strains of poultry origin in India to a variety of antimicrobials especially fluoroquinolones.

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Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.

Cited by 175 publications

References 40 publications

Joint Opinion on antimicrobial resistance (AMR) focused on zoonotic infections

Joint Opinion on antimicrobial resistance (AMR) focused on zoonotic infections

Anti Campylobacter Activity of Extracts of Daphne Mucronata and Symplocos Racemosa Against Avian Isolates

Molecular identification and antimicrobial resistance profiles of Campylobacter strains of poultry origin in India with special emphasis on fluoroquinolone resistance

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