Mechanisms of Hepato-Renal Protective Activity of Ocimum basilicum Leaf Extract against Paracetamol Toxicity in Rat Model

Soliman, Ahmed M.; Rizk, Hanan A.; Shalaby, Mohamed A.; Elkomy, Ashraf

doi:10.17582/journal.aavs/2020/8.4.385.391

Cited by 14 publications

(18 citation statements)

References 10 publications

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“…In the present study, AEAASB caused a significant decrease in MDA levels and an increase in SOD, CAT, and GSH levels in the liver and kidney. These results are in line with those obtained by Soliman et al [13] who showed that the ethanolic extract of O. basilicum prevented paracetamol toxicity by enhancing the antioxidant status by decreasing MDA levels and increasing antioxidant enzyme levels in liver and kidney tissue. In addition, the results of in vitro antioxidant tests showed that AEAASB is a very strong antioxidant (IC 50 = 180 μg/ml, AAI = 5:55) that has the ability to scavenge 63.03% of DPPH• radicals and reduce ferric iron by 52.68 mgEqVitC/100 g DM.…”

Section: Discussionsupporting

confidence: 93%

“…Hence, the high level of MDA and low levels of GSH, SOD, and CAT were observed in the group of untreated animals that received paracetamol (negative control). Substances that increase GSH, SOD, and CAT levels and decrease MDA levels are known to inhibit paracetamol-induced liver and kidney injury formation [ 13 ]. In the present study, AEAASB caused a significant decrease in MDA levels and an increase in SOD, CAT, and GSH levels in the liver and kidney.…”

Section: Discussionmentioning

confidence: 99%

“…As the damage induced by paracetamol is mainly oxidative, natural compounds with antioxidant activity could be used as alternative treatments for paracetamol-induced hepatorenal toxicity [ 6 ]. Several studies have shown the efficacy of medicinal plant extracts on paracetamol-induced toxicity, including the works of Sudip et al [ 12 ], Soliman et al [ 13 ], and Al-Asmari et al [ 14 ], which showed, respectively, the protective effects of Citrus macroptera fruit extracts, Ocimum basilicum leaves, and Phoenix dactylifera pollen on paracetamol-induced hepatorenal toxicity in rats.…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant Mechanism of Renal and Hepatic Failure Prevention Related to Paracetamol Overdose by the Aqueous Extract of Amblygonocarpus andongensis Stem Bark

Baponwa

Amang

Mezui

et al. 2022

BioMed Research International

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Paracetamol is a commonly used analgesic/antipyretic whose long-term intake or overdose is associated with renal and hepatic injuries. The aim of this study was to determine the hepatonephroprotective mechanisms of the aqueous extract of Amblygonocarpus andongensis stem bark (AEAASB) on renal and hepatic failure resulting from paracetamol overdose. Forty-five rats were divided into nine groups ( n = 5 ); these were treated once daily for 8 days with 5 ml/kg distilled water (normal, negative, and satellite controls); 0.9% normal saline and 140 mg/kg N-acetyl-cysteine (positive controls); 125, 250, and 500 mg/kg AEAASB (test groups); and 500 mg/kg AEAASB (satellite test). On day 8 after different treatments, hepatonephrotoxicity was induced in all the groups except the normal group by oral administration of a single dose of paracetamol (1000 mg/kg). Urinary, hematological, serum, and oxidative stress parameters and in vitro antioxidant activity of AEAASB were evaluated. Histological sections of the liver and kidney were performed. AEAASB significantly decreased urea, creatinine, transaminases, alkaline phosphatase, and bilirubin ( p < 0.001 ) at 500 mg/kg compared to the negative control. Significant decreases in hepatic ( p < 0.01 ) and renal ( p < 0.001 ) malondialdehyde levels were associated with increases in superoxide dismutase, catalase, and reduced glutathione levels in 500 mg/kg AEAASB compared with the negative control. Histological analysis showed that AEAASB prevented paracetamol-induced renal and liver tissue damage. Furthermore, AEAASB revealed a very strong antioxidant activity (inhibitory concentration 50 = 180 μ g / ml , antioxidant activity index = 5.55 ) with an ability to scavenge 63.03% 2,2-diphenyl-2-picrylhy-drazyl radical and reduced ferric iron by 52.68 mgEqVitC/100 g DM. The hepatonephroprotective effect of AEAASB might result from its ability to improve the antioxidant status through the stimulation of antioxidant factors and the scavenging of free radicals. This property could be ascribed to the presence of some classes of bioactive compounds such as phenolic compounds in great amounts.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antioxidant Mechanism of Renal and Hepatic Failure Prevention Related to Paracetamol Overdose by the Aqueous Extract of Amblygonocarpus andongensis Stem Bark

Baponwa

Amang

Mezui

et al. 2022

BioMed Research International

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“…Renoprotective effect against diabetes induced renal affection in albino rats 500 mg/kg of body weight/day; given to rats through gastric tube for six weeks) [120] Leaves Ethanolic extract Rats Hepato-renal protective against paracetamol toxicity in rat model 200-400 mg/kg of body weight; once daily for 30 consecutive days) [121] Aerial parts Hydroalcoholic extract Rats…”

Section: Aerial Partsmentioning

confidence: 99%

Inventory of Medicinal Plants Used Traditionally to Manage Kidney Diseases in North-Eastern Morocco: Ethnobotanical Fieldwork and Pharmacological Evidence

Bencheikh

Elbouzidi

Kharchoufa

et al. 2021

Plants

153

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Kidney disease is one of the most common health problems and kidney failure can be fatal. It is one of the health disorders associated with extreme pain and discomfort in patients. In developing countries, such as Morocco where socioeconomic and sanitary conditions are precarious, medicinal plants are considered the primary source of medication. In the present work an ethnobotanical survey was conducted in a remote area of North-Eastern Morocco and we focused on (1) establishing a record of medicinal plants used traditionally by local people to treat kidney diseases and (2) correlate the obtained ethnomedical use with well-studied pharmacological evidence. From February 2018 to January2020, information was gathered from 488 informants using semi-structured questionnaires. The data were analyzed using three quantitative indices: The use value (UV), family use value (FUV), and informant consensus factor (ICF). A total of 121 plant species belonging to 57 botanical families were identified to treat kidney diseases. The families most represented were Asteraceae (14 species), followed by Lamiaceae (12 species) and Apiaceae (10 species). The most commonly used plant parts were leaves, followed by the whole plant and they were most commonly prepared by decoction and infusion. The highest value of the (UV) index was attributed to Herniaria hirsuta L. (UV = 0.16), and the highest family use value (FUV) was assigned to Caryophyllaceae with (FUV = 0.163). Regarding the informant consensus factor (ICF), this index’s highest values were recorded for kidney stones (ICF = 0.72). The use of 45% of the selected plants were validated based on literature review. This study helped document and preserve crucial traditional plant knowledge of 121 plant species used to treat kidney problems that can be used in the search for new biologically active compounds through more upcoming pharmacological studies.

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“…Pemberian Paracetamol secara oral pada peneliti (Soliman et al, 2020) dengan dosis 500 mg/kgBB selama 30 hari menyebabkan peningkatan yang signifikan pada kadar trigliserida. Pada kelompok tikus yang diberikan paracetamol dengan dosis 500 mg/kgBB dan Ekstrak kemangi dosis 200 mg/kgBB selama 30 hari mengalami penurunan.…”

Section: B Pembahasanunclassified

Studi Literatur Pengaruh Pemberian Ekstrak Kemangi (Ocimum Basilicum L.) Terhadap Kadar Trigliserida pada Tikus Putih (Rattus Norvegicus) Jantan Galur Wistar yang diberi Diet Tinggi Lemak

Fitriani

Hasbie

Aprilianti

2021

cerdika

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Obesitas merupakan timbunan triasil gliserol berlebih dijaringan lemak akibat asupan energi berlebih dalam waktu yang lama. Obesitas berhubungan dengan kadar serum tidak normal. Trigliserida adalah ester dari alkohol gliserol dengan asam lemak. Daun kemangi memiliki senyawa fitokimia antara lain flavonoid, asam galat, glikolisit, saponin, asam caseic, dan minyak atsiri yang mengandung eugenol (70,5%) sebagai komponen utama. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak kemangi (Ocimum basilicum L.) terhadap kadar trigliserida, mengetahui dosis dan lama pemberian ekstrak kemangi yang efektif dalam menurunkan kadar trigliserida. Metode penelitian yang digunakan adalah desain penelitian deskriptif. Studi pustaka (literature review) menggunakan database google scholar dan PubMed dengan menggunakan kata kunci yang digunakan dalam pencarian data untuk menelusuri jurnal yang terkait dengan ekstrak kemangi, trigliserida, tikus, dan diet tinggi. Hasil penelitian dari 11 jurnal yang telah di telaah bahwa pemberian ekstrak kemangi dapat menurunkan kadar trigliserida dengan dosis pemberian 200 mg/kgBB dapat menurunkan kadar trigliserida sebanyak 70% dengan lama pemberian 5 dan 6 minggu. Kesimpulan penelitian ini yaitu pemberian ekstrak kemangi efektif menurunkan kadar trigliserida pada tikus putih (Rattus norvegicus)jantan dengan dosis pemberian 200 mg/kgBB selama 5 dan 6 minggu menurunkan sebanyak 70%.

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Mechanisms of Hepato-Renal Protective Activity of Ocimum basilicum Leaf Extract against Paracetamol Toxicity in Rat Model

Abstract: Kidneys has an important role in removing wastes like

Cited by 14 publications

References 10 publications

Antioxidant Mechanism of Renal and Hepatic Failure Prevention Related to Paracetamol Overdose by the Aqueous Extract of Amblygonocarpus andongensis Stem Bark

Antioxidant Mechanism of Renal and Hepatic Failure Prevention Related to Paracetamol Overdose by the Aqueous Extract of Amblygonocarpus andongensis Stem Bark

Inventory of Medicinal Plants Used Traditionally to Manage Kidney Diseases in North-Eastern Morocco: Ethnobotanical Fieldwork and Pharmacological Evidence

Studi Literatur Pengaruh Pemberian Ekstrak Kemangi (Ocimum Basilicum L.) Terhadap Kadar Trigliserida pada Tikus Putih (Rattus Norvegicus) Jantan Galur Wistar yang diberi Diet Tinggi Lemak

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