Mechanisms of human cell resistance to mutagens

Comparative analysis of gene expression in human blood cells and in rhabdomyosarcoma cells pretreated with antimutagens

“…As was shown by us earlier, the natural antimutagen β purothionine, consisting of 45 amino acid residues, has a number of properties characteristic of extracts of seedlings of the plant from which it was isolated: anti radical activity, stimulation of suppressor genes, and inhibition of oncogenes and other genes controlling carcinogenesis [11,12]. Thus, this drug can also be regarded as a promising anticarcinogen.…”