Mechanisms of Immunotoxicity: Stressors and Evaluators

Zerdan, Maroun Bou; Moussa, Sara; Atoui, Ali; Assi, Hazem

doi:10.3390/ijms22158242

Cited by 32 publications

(14 citation statements)

References 213 publications

(241 reference statements)

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“…Several studies stated that BPA can bind T cells affecting Th17, Th1, and Th2 differentiation [ 50 ]. BPA significantly increased the IFN-γ and IL-4 secretion in animal models, suggesting a possible upregulation of the Th1 response [ 55 , 56 ]. In a paper published by S. Yoshino et al in 2005, mice treated with BPA prenatally were reported to have a Th1-cytokine secretion pattern [ 57 ].…”

Section: Bisphenol a Effects On Human Healthmentioning

confidence: 99%

Current Evidence on Bisphenol A Exposure and the Molecular Mechanism Involved in Related Pathological Conditions

et al. 2023

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Bisphenol A (BPA) is one of the so-called endocrine disrupting chemicals (EDCs) and is thought to be involved in the pathogenesis of different morbid conditions: immune-mediated disorders, type-2 diabetes mellitus, cardiovascular diseases, and cancer. The purpose of this review is to analyze the mechanism of action of bisphenol A, with a special focus on mesenchymal stromal/stem cells (MSCs) and adipogenesis. Its uses will be assessed in various fields: dental, orthopedic, and industrial. The different pathological or physiological conditions altered by BPA and the related molecular pathways will be taken into consideration.

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Section: Bisphenol a Effects On Human Healthmentioning

confidence: 99%

Current Evidence on Bisphenol A Exposure and the Molecular Mechanism Involved in Related Pathological Conditions

et al. 2023

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“…Such positive antagonistic effects between parasitism and contaminant exposure could reflect sequestering of contaminants by the parasite. Stimulatory and suppressive effects of contaminants on immune parameters in endotherms have been reported (Desforges et al, 2016; Vallverdú‐Coll et al, 2019), with diverse mechanisms implicated, including interference with the aryl hydrocarbon receptor (Bou Zerdan et al, 2021; Suzuki et al, 2020). For instance, in polar bears, PCBs and OCPs have immunosuppressive effects on circulating immunoglobulin class G, production of viral antibodies, and proliferation of T and B lymphocytes (Routti et al, 2019).…”

Section: Interactive Effects Across Bioenergetic Domainsmentioning

confidence: 99%

Combined threats of climate change and contaminant exposure through the lens of bioenergetics

Grunst

Grémillet

et al. 2023

Global Change Biology

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Organisms face energetic challenges of climate change in combination with suites of natural and anthropogenic stressors. In particular, chemical contaminant exposure has neurotoxic, endocrine‐disrupting, and behavioral effects which may additively or interactively combine with challenges associated with climate change. We used a literature review across animal taxa and contaminant classes, but focused on Arctic endotherms and contaminants important in Arctic ecosystems, to demonstrate potential for interactive effects across five bioenergetic domains: (1) energy supply, (2) energy demand, (3) energy storage, (4) energy allocation tradeoffs, and (5) energy management strategies; and involving four climate change‐sensitive environmental stressors: changes in resource availability, temperature, predation risk, and parasitism. Identified examples included relatively equal numbers of synergistic and antagonistic interactions. Synergies are often suggested to be particularly problematic, since they magnify biological effects. However, we emphasize that antagonistic effects on bioenergetic traits can be equally problematic, since they can reflect dampening of beneficial responses and result in negative synergistic effects on fitness. Our review also highlights that empirical demonstrations remain limited, especially in endotherms. Elucidating the nature of climate change‐by‐contaminant interactive effects on bioenergetic traits will build toward determining overall outcomes for energy balance and fitness. Progressing to determine critical species, life stages, and target areas in which transformative effects arise will aid in forecasting broad‐scale bioenergetic outcomes under global change scenarios.

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“…Evidence has shown that AFB1-mediated oxidative stress is equally or even more responsible for AF-induced genotoxicity. The second-most documented toxicological effect of AFs is probably immunotoxicity, and its mechanisms of action (immunosuppressive and immunostimulatory actions) have been extensively illustrated [ 121 ]. Apart from the above, malnutrition, disease, impaired child growth, retardation of physical and mental maturity, reproduction, nervous system diseases, etc., are some other AF-induced acute and chronic health issues reported in mammals.…”

Section: Health Effects and Mechanism Of Toxicitymentioning

confidence: 99%

Aflatoxins in Cereals and Cereal-Based Products: Occurrence, Toxicity, Impact on Human Health, and Their Detoxification and Management Strategies

Kumar

Gupta

Mahato

et al. 2022

Toxins

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Cereals and cereal-based products are primary sources of nutrition across the world. However, contamination of these foods with aflatoxins (AFs), secondary metabolites produced by several fungal species, has raised serious concerns. AF generation in innate substrates is influenced by several parameters, including the substrate type, fungus species, moisture content, minerals, humidity, temperature, and physical injury to the kernels. Consumption of AF-contaminated cereals and cereal-based products can lead to both acute and chronic health issues related to physical and mental maturity, reproduction, and the nervous system. Therefore, the precise detection methods, detoxification, and management strategies of AFs in cereal and cereal-based products are crucial for food safety as well as consumer health. Hence, this review provides a brief overview of the occurrence, chemical characteristics, biosynthetic processes, health hazards, and detection techniques of AFs, along with a focus on detoxification and management strategies that could be implemented for food safety and security.

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Mechanisms of Immunotoxicity: Stressors and Evaluators

Cited by 32 publications

References 213 publications

Current Evidence on Bisphenol A Exposure and the Molecular Mechanism Involved in Related Pathological Conditions

Current Evidence on Bisphenol A Exposure and the Molecular Mechanism Involved in Related Pathological Conditions

Combined threats of climate change and contaminant exposure through the lens of bioenergetics

Aflatoxins in Cereals and Cereal-Based Products: Occurrence, Toxicity, Impact on Human Health, and Their Detoxification and Management Strategies

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