Mechanisms of Linezolid Resistance among Staphylococci in a Tertiary Hospital

Quiles-Melero, Inmaculada; Gómez-Gil, Rosa; Romero-Gómez, María Pilar; Sánchez-Díaz, Ana Maria; Pablos, Manuela de; García-Rodríguez, Julio; Gutierrez, A.; Mingorance, Jesús

doi:10.1128/jcm.01598-12

Cited by 29 publications

(17 citation statements)

References 26 publications

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“…Linezolid belongs to the oxazolidone class of antibiotics and is a protein synthesis inhibitor (Kloss et al, 1999 ) with bacteriostatic action. The resistance gene responsible for linezolid resistance was identified as cfr gene, encoding a methyltransferase that modifies the 23S rRNA site of the 50S ribosomal subunit, preventing linezolid to bind to it (Toh et al, 2007 ; Quiles-Melero et al, 2012 ). Work on these organisms reported the presence of cfr gene in chromosomes of clinical human MRSA isolates as being responsible for mediating resistance in MRSA (Morales et al, 2010 ).…”

Section: The Mechanisms Of Antibiotic Resistance In Mrsamentioning

confidence: 99%

Streptomyces as a Prominent Resource of Future Anti-MRSA Drugs

et al. 2018

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Methicillin-resistant Staphylococcus aureus (MRSA) pose a significant health threat as they tend to cause severe infections in vulnerable populations and are difficult to treat due to a limited range of effective antibiotics and also their ability to form biofilm. These organisms were once limited to hospital acquired infections but are now widely present in the community and even in animals. Furthermore, these organisms are constantly evolving to develop resistance to more antibiotics. This results in a need for new clinically useful antibiotics and one potential source are the Streptomyces which have already been the source of several anti-MRSA drugs including vancomycin. There remain large numbers of Streptomyces potentially undiscovered in underexplored regions such as mangrove, deserts, marine, and freshwater environments as well as endophytes. Organisms from these regions also face significant challenges to survival which often result in the production of novel bioactive compounds, several of which have already shown promise in drug development. We review the various mechanisms of antibiotic resistance in MRSA and all the known compounds isolated from Streptomyces with anti-MRSA activity with a focus on those from underexplored regions. The isolation of the full array of compounds Streptomyces are potentially capable of producing in the laboratory has proven a challenge, we also review techniques that have been used to overcome this obstacle including genetic cluster analysis. Additionally, we review the in vivo work done thus far with promising compounds of Streptomyces origin as well as the animal models that could be used for this work.

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Section: The Mechanisms Of Antibiotic Resistance In Mrsamentioning

confidence: 99%

Streptomyces as a Prominent Resource of Future Anti-MRSA Drugs

et al. 2018

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“…Linezolid binds to the 50S ribosomal subunit of the 23S rRNA molecule and inhibits protein synthesis. Cfr gene encodes a methyltransferase that modifies the 23S rRNA site of the 50S ribosomal subunit and prevents linezolid from binding to it [14]. Q/D is composed of two streptogramins (70% dalfopristin (streptogramin A) and 30% quinupristin (streptogramin B)), which was approved in 1999 as a treatment option for VRE and MRSA infections.…”

Section: Introductionmentioning

confidence: 99%

The global prevalence of Daptomycin, Tigecycline, Quinupristin/Dalfopristin, and Linezolid-resistant Staphylococcus aureus and coagulase–negative staphylococci strains: a systematic review and meta-analysis

Shariati

Dadashi

Chegini

et al. 2020

Antimicrob Resist Infect Control

115

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“…The safety and tolerability of linezolid favour its use in prolonged treatments, but it should be taken into account that continuous exposures during long periods increase the chance of selecting isolates with higher mutation dosages and higher linezolid MICs. [5][6][7][8] …”

Section: Enterococcus Faecium Resistente a Linezolid Y Vancomicina Aimentioning

confidence: 98%