Mechanisms of Modulating Action of Low-Intensity Laser Radiation on the Proliferative Activity of Cells in the Stromal and Vascular Fraction of Adipose Tissue

Abstract

The efficacy of low-intensity laser radiation therapy using autologous cellular products based on adipose tissue, including stromalvascular fraction, has been shown to be effective in different forms of pathology and in reconstructive and plastic surgery. The review deals with the issues related to the methodological aspects of the stromal and vascular fraction isolation from the human adipose tissue as well as with the peculiarities of its application in experimental studies on animal models and in clinical practice. The mechanisms of low-intensity laser radiation effect on the cells of stromal-vascular fraction has been discussed. An analysis of recently published research results on the effects of laser radiation on mesenchymal stromal cells of adipose tissue is carried out. The results of experimental studies on the choice of optimal modes and parameters of low-intensity laser radiation with the aim of their application in complex cell technologies are discussed. The issues related to the therapeutic effects of low-intensity physical factors in autologous transplantation of the stromal-vascular fraction and mesenchymal stromal cells in various types of pathology are viewed. Further research on the mechanisms of low-intensity laser irradiation effects on various types of cells and tissues is required to expand the clinical application of cell-based therapy