Mechanisms of probiotic Bacillus against enteric bacterial infections

Zhu, Jiajia; Chen, Yunsheng; Imre, K.; Arslan‐Acaröz, Damla; Istanbullugil, Fatih Ramazan; Fang, Yuwen; Ros, Gaspar; Zhu, Kui; Acaröz, Ulaş

doi:10.1186/s44280-023-00020-0

Cited by 8 publications

(3 citation statements)

References 211 publications

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“…The HGT and gene loss might also drive the variation in GCs between related strains [ 36 ] and the similarity of GCs between unrelated strains within the same population [ 43 ]. Furthermore, the distribution of secondary metabolite GCs, including bacteriocins, can be phylogenetically conserved, as was previously observed in Bacillus [ 32 , 44 , 45 ]. Overall, the prevalence of bacteriocin GCs is strain-specific, and the diversity and distribution of those genes are associated with evolutionary and ecological factors.…”

Section: Discussionmentioning

confidence: 53%

In Silico Screening of Bacteriocin Gene Clusters within a Set of Marine Bacillota Genomes

Teber,

Asakawa

2024

IJMS

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Due to their potential application as an alternative to antibiotics, bacteriocins, which are ribosomally synthesized antimicrobial peptides produced by bacteria, have received much attention in recent years. To identify bacteriocins within marine bacteria, most of the studies employed a culture-based method, which is more time-consuming than the in silico approach. For that, the aim of this study was to identify potential bacteriocin gene clusters and their potential producers in 51 marine Bacillota (formerly Firmicutes) genomes, using BAGEL4, a bacteriocin genome mining tool. As a result, we found out that a majority of selected Bacillota (60.78%) are potential bacteriocin producers, and we identified 77 bacteriocin gene clusters, most of which belong to class I bacteriocins known as RiPPs (ribosomally synthesized and post-translationally modified peptides). The identified putative bacteriocin gene clusters are an attractive target for further in vitro research, such as the production of bacteriocins using a heterologous expression system.

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Section: Discussionmentioning

confidence: 53%

In Silico Screening of Bacteriocin Gene Clusters within a Set of Marine Bacillota Genomes

Teber,

Asakawa

2024

IJMS

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“…In addition, probiotic bacteria and their metabolites can diffuse into the gut lumen and modify the community, resulting in the elimination of enteric pathogens such as Salmonella. Salmonella continues to pose a significant challenge in the domains of food safety and public health, thereby prompting the enforcement of diverse measures for its control, encompassing the examination and oversight of food products Ehuwa et al, 2021;Hardy, 2004;Zhu et al, 2023).…”

Section: Antimicrobial Effects Of Honey On Salmonellamentioning

confidence: 99%

A Review on the Antimicrobial Effect of Honey on Salmonella and Listeria monocytogenes: Recent Studies

İSTANBULLUGİL,

TAŞ,

ACARÖZ

et al. 2023

Manas Journal of Agriculture Veterinary and Life Sciences

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Foodborne pathogens like Salmonella and Listeria monocytogenes are microbial agents capable of causing severe illnesses, and they pose a perpetual menace to the food industry. Given their potential to jeopardize human health, both food producers and consumers hold significant concerns regarding these pathogens. The quest for novel strategies and natural preservatives in the domain of food safety holds paramount importance in the effort to curtail the dissemination and contamination of these pathogens. In this context, honey stands out as a notable natural product with substantial potential. Honey, through its bioactive constituents, including phenolic compounds, specialized enzymes, and particularly the production of hydrogen peroxide, can serve as an efficacious tool in combatting microorganisms. This review undertakes an exploration of the antimicrobial impacts of honey on Salmonella and Listeria monocytogenes by conducting a comprehensive assessment of existing literature and consolidating available data. The existing data strongly indicates the potential of honey's antimicrobial components to hinder the proliferation and dissemination of these pathogens. This review's principal aim is to outline a path for future research and applications, acknowledging the essential need for additional data and thorough investigations before efficiently deploying honey as a countermeasure against these pathogens.

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“…Bacillus bacteria synthesize a number of antimicrobial compounds characterized by a selective activity against pathogens, but not beneficial microbiota [20][21][22]. Such antimicrobial metabolites have different mechanisms of action.…”

Section: Introductionmentioning

confidence: 99%

Bacillus subtilis RBT-7/32 and Bacillus licheniformis RBT-11/17 as New Promising Strains for Use in Probiotic Feed Additives

Yaderets,

Karpova,

Glagoleva

et al. 2023

Microorganisms

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The normal functioning of a gastrointestinal microflora in poultry and livestock is of significant importance, since its imbalance negatively influences an organism’s functions. In this study, the UV mutagenesis and selection were used to obtain two Bacillus strains possessing antagonistic activity towards Escherichia coli and Staphylococcus aureus, and their potential as a probiotic feed additive was evaluated. Compared to the parental strains, the ability of B. subtilis RBT-7/32 and B. licheniformis RBT-11/17 strains to suppress E. coli increased by 77 and 63%, respectively; the corresponding ability of these strains to suppress S. aureus increased by 80 and 79%, respectively. RBT-11/17 could not utilize microcrystalline cellulose and carboxymethyl cellulose, whereas cellulolytic activity of RBT-7/32 was doubled compared to the initial strain. The amylolytic activity of new strains was increased by 40%. Cultivation of strains on media containing soybean, pea, and corn meal did not provide any difference in the biomass production compared to the control. The heating of a water suspension of a dried biomass of the strains for 10–20 min at 80 and 100 °C or incubation in water solutions of citric, ascorbic, acetic, and formic acids (pH 3.0) for 3 and 24 h at 40 °C did not provide any negative influence on the spore survivability. Both strains were evaluated for their resistance to a number of veterinary antibiotics. Thus, RBT-7/32 and RBT-11/17 strains have good prospects for use in feed additives.

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Mechanisms of probiotic Bacillus against enteric bacterial infections

Cited by 8 publications

References 211 publications

In Silico Screening of Bacteriocin Gene Clusters within a Set of Marine Bacillota Genomes

In Silico Screening of Bacteriocin Gene Clusters within a Set of Marine Bacillota Genomes

A Review on the Antimicrobial Effect of Honey on Salmonella and Listeria monocytogenes: Recent Studies

Bacillus subtilis RBT-7/32 and Bacillus licheniformis RBT-11/17 as New Promising Strains for Use in Probiotic Feed Additives

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