Mechanisms of Radioresistance in Cancer Stem Cells

Lee, Cleo; Diehn, Maximilian

doi:10.1007/978-1-61779-246-5_20

Cited by 1 publication

(1 citation statement)

References 84 publications

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“…(6) CSCs may be located in hypoxic niches within tumors which would contribute to resistance to radiation. (139) There is raising evidence that polycomb group (PcG) proteins (discovered in Drosophila as epigenetic gene silencers) play an important role in cancer development and recurrence. PcG of proteins is composed of two multimeric protein complexes, which are the polycomb repressive complex (PRC)1 and PRC2.…”

Section: Csc Conceptmentioning

confidence: 99%

Cancer Stem Cell Hypothesis: Implication for Cancer Prevention and Treatment

Meiliana

Dewi²,

Wijaya

2016

Indones Biomed J

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BACKGROUND: Cancer is a disease of genomic instability, evasion of immune cells, and adaptation of the tumor cells to the changing environment. Genetic heterogeneity caused by tumors and tumor microenvironmental factors forms the basis of aggressive behavior of some cancer cell populations.CONTENT: Cancers arise in self-renewing cell populations and that the resulting cancers, like their normal organ counterparts, are composed of hierarchically organized cell populations. Self – renewing “cancer stem cells” (CSC) maintain tumor growth and generate the diverse populations constituting the tumor bulk. CSCs in multiple tumor types have been demonstrated to be relatively resistant to radiation and chemotherapy. The clinical relevance of these studies has been supported by neoadjuvant breast cancer trials that demonstrated increases in the proportions of CSCs after therapy. The CSC hypothesis has tremendously important clinical implications.SUMMARY: In summary, a large and accumulating body of evidence supports the CSC hypothesis, which has important implications for cancer prevention and therapy. The ultimate test of this hypothesis will require clinical trials demonstrating that targeting of these pathways reduces cancer incidence and improves outcomes for patients with cancer.KEYWORDS: Somatic mutation, tumor heterogeneity, metastasis, epithelial-mesenchymal transition, CSC niche

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Section: Csc Conceptmentioning

confidence: 99%