Mechanisms of Resetting Reentrant Circuits in Canine Ventricular Tachycardia

Hanna, Michael; Coromilas, James; Josephson, Mark E.; Wit, Andrew L.; Peters, Nicholas S.

doi:10.1161/01.cir.103.8.1148

Cited by 9 publications

(4 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is likely that this observation results from a combination of properties of the DP, including structural features, such as change in muscle fiber orientation causing conduction anisotropy at entry to and within the DP (demonstrated in the canine infarct model) (1,3,12), and functional factors, including current source/sink relationships and altered gap-junctional organization (16). We have previously demonstrated that the greatest degree of conduction slowing in human infarct-related VT circuits occurs at changes of trajectory within the DP (10).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Characterization of the Effects of Single Ventricular Extrastimuli on Endocardial Activation in Human Infarct-Related Ventricular Tachycardia

Segal

Chow

Markides

et al. 2007

Journal of the American College of Cardiology

Self Cite

View full text Add to dashboard Cite

In infarct-related VT, all circuits can be pre-excited over a range of SVEs, the effect of which is dependent on the degree of IDCS within the DP or modification of functional block defining the circuit. Failure to reset does not therefore indicate the absence of an EGap or failure of entry to the circuit. The temporal and spatial properties of the EGap vary at different sites of entry to the circuit.

show abstract

Section: Discussionmentioning

confidence: 99%

“…We have previously examined the interaction between extrastimuli and functional components of VT circuits and properties of the EGap in the well characterized canine infarct model with epicardial isochronal mapping (3,12). We demonstrated that temporal and spatial qualities of the EGap vary at different points within the circuit (12).…”

mentioning

confidence: 99%

Characterization of the Effects of Single Ventricular Extrastimuli on Endocardial Activation in Human Infarct-Related Ventricular Tachycardia

Segal

Chow

Markides

et al. 2007

Journal of the American College of Cardiology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Many studies were carried out to specify the nature and the importance of excitable gaps during reentry in the anisotropic myocardium (7,116,125,248,253,295,360). It should be pointed out that there are no major differences in the principles that govern the behavior of rotors and spiral waves in isotropic and anisotropic media as long as the media are continuous, i.e., devoid of discontinuities in passive or active electric properties (167,248,373).…”

Section: Relation Between Excitable Gaps and Structurementioning

confidence: 99%

Basic Mechanisms of Cardiac Impulse Propagation and Associated Arrhythmias

Kléber

Rudy

2004

Physiological Reviews

941

794

View full text Add to dashboard Cite

Propagation of excitation in the heart involves action potential (AP) generation by cardiac cells and its propagation in the multicellular tissue. AP conduction is the outcome of complex interactions between cellular electrical activity, electrical cell-to-cell communication, and the cardiac tissue structure. As shown in this review, strong interactions occur among these determinants of electrical impulse propagation. A special form of conduction that underlies many cardiac arrhythmias involves circulating excitation. In this situation, the curvature of the propagating excitation wavefront and the interaction of the wavefront with the repolarization tail of the preceding wave are additional important determinants of impulse propagation. This review attempts to synthesize results from computer simulations and experimental preparations to define mechanisms and biophysical principles that govern normal and abnormal conduction in the heart.

show abstract

“…Cardiac conduction velocity (CV) describes the speed and direction of propagation of the action potential wavefront through myocardium. It can provide important quantitative electrophysiological information about the underlying tissue microarchitecture and is widely used in both laboratory [1,2] and clinical electrophysiological studies [3,4] to infer properties of the myocardial substrate and to identify potential mechanisms for arrhythmogenesis [5–7] . Conduction velocity measurements provide an important quantity in identifying potential reentrant circuits and regions of tissue which, for example, might act as an anchor point for rotors [8] .…”

Section: Introductionmentioning

confidence: 99%

Techniques for automated local activation time annotation and conduction velocity estimation in cardiac mapping

Cantwell

Roney

et al. 2015

Computers in Biology and Medicine

167

137

View full text Add to dashboard Cite

Measurements of cardiac conduction velocity provide valuable functional and structural insight into the initiation and perpetuation of cardiac arrhythmias, in both a clinical and laboratory context. The interpretation of activation wavefronts and their propagation can identify mechanistic properties of a broad range of electrophysiological pathologies. However, the sparsity, distribution and uncertainty of recorded data make accurate conduction velocity calculation difficult. A wide range of mathematical approaches have been proposed for addressing this challenge, often targeted towards specific data modalities, species or recording environments. Many of these algorithms require identification of activation times from electrogram recordings which themselves may have complex morphology or low signal-to-noise ratio. This paper surveys algorithms designed for identifying local activation times and computing conduction direction and speed. Their suitability for use in different recording contexts and applications is assessed.

show abstract

Mechanisms of Resetting Reentrant Circuits in Canine Ventricular Tachycardia

Abstract: Multiple mechanisms revealed by mapping cause resetting of reentrant circuits.

Cited by 9 publications

References 19 publications

Characterization of the Effects of Single Ventricular Extrastimuli on Endocardial Activation in Human Infarct-Related Ventricular Tachycardia

Characterization of the Effects of Single Ventricular Extrastimuli on Endocardial Activation in Human Infarct-Related Ventricular Tachycardia

Basic Mechanisms of Cardiac Impulse Propagation and Associated Arrhythmias

Techniques for automated local activation time annotation and conduction velocity estimation in cardiac mapping

Contact Info

Product

Resources

About