Mechanisms of target organ damage caused by hypertension: Therapeutic potential

Cohuet, Géraldine; Struijker‐Boudier, Harry A.J.

doi:10.1016/j.pharmthera.2005.09.002

Cited by 135 publications

(110 citation statements)

References 220 publications

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“…The animals were placed in a heated chamber at an ambient temperature of 30-34 °C for 15 min and blood pressure values (1)(2)(3)(4)(5)(6)(7)(8)(9) were recorded for each animal. The lowest three readings were averaged to calculate the mean blood pressure.…”

Section: Blood Pressure Measurementsmentioning

confidence: 99%

“…Although these agents have been widely used in treatment of hypertension and congestive heart failure, there are only a few preclinical and clinical studies in which ACE inhibitors have been shown to reduce the incidence of dementia or slow down the rate of cognitive decline in patients with hypertension. Furthermore, the significance of ACE inhibitor usage in hypertension-induced cerebrovascular and neurodegenerative diseases is still unknown [8,9]. Lisinopril, a new non-sulfhydryl ACE inhibitor which can pass through the blood-brain barrier, is absorbed in its active form and primarily excreted with urine [10].…”

Section: Introductionmentioning

confidence: 99%

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Effects of lisinopril on oxidative stress in brain tissues of rats with L-NAME induced hypertension

Kırbaş¹,

Kutluhan²,

Kırbaş³

et al. 2013

Turk J Bioch

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Objective: Arterial hypertension is often associated with pathologies related with oxidative stress. Angiotensin converting enzyme (ACE) inhibitors have been used as a safe and effective treatment of hypertension and coronary heart disease. However, the significance of ACE inhibitor usage in hypertension-induced cerebrovascular and neurodegenerative diseases is still unknown. In this study, we aimed to investigate the effects of lisinopril, an ACE inhibitor, on oxidative stress and antioxidant enzyme activities in brain tissues of rats with L-NAME (N ω -Nitro-L-Arginine Methyl Ester hydrochloride) induced hypertension. Methods: Thirty-two Sprague-Dawley rats were divided into four groups: Control, L-NAME, L-NAME plus lisinopril, and only lisinopril. Hypertension was induced by oral administration of the L-NAME (75 mg/kg/day) in drinking water for 6 weeks. Rats were treated with Lisinopril (10 mg/kg/day) for six weeks. Systolic blood pressures were measured at the first, third and sixth weeks by using tail cuff method. Malondialdehyde (MDA), Superoxide dismutase (SOD), Catalase (CAT) and Glutathione peroxidase (GSH-Px) activity were measured from the brain tissue. Nitric oxide (NO) levels were measured from plasma. Results: Our results showed that L-NAME leads to an increase in systolic blood pressure of animals. The antihypertensive effect of lisinopril was observed. MDA level was significantly increased, and antioxidant enzymes activities were decreased in L-NAME given group (p<0.05). However, there was no statistically significant differences between the lisinopril given and other groups according to antioxidant enzymes activities (p>0.05). Conclusion: In our study, hypertension led to oxidative damage in brain tissues. Although lisinopril prevents the hypertension induced oxidative damage, direct antioxidant effect was not observed. Further studies are needed in order to gain certainty effect of lisinopril in brain tissue.

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Section: Blood Pressure Measurementsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of lisinopril on oxidative stress in brain tissues of rats with L-NAME induced hypertension

Kırbaş¹,

Kutluhan²,

Kırbaş³

et al. 2013

Turk J Bioch

View full text Add to dashboard Cite

show abstract

“…Advanced retinopathy is nowadays confirmed as hypertension-induced target organ damage (Cohuet, 2006). Signs of hypertensive retinopathy are frequently seen in adults 40 years and older, and are predictive for stroke, congestive heart failure, and cardiovascular mortality-independently from traditional risk factors (Wong, 2007).…”

Section: Hypertension-induced Retinal Damagementioning

confidence: 99%

Specific Features of Target Organ Damage in Patients with Arterial Hypertension and Coronary Artery Disease

Şerban¹,

Christodorescu²,

Caraba³

et al. 2012

Coronary Artery Diseases

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“…Yet at the same time they act as mediators of inflammation in atherosclerosis (201), hypertension (96), and target organ damage (68,178,276,284,297). This functional duality has yet to be satisfactorily explained.…”

Section: The Kallikrein-kinin System In Inflammationmentioning

confidence: 99%