Mechanisms of the cerebral vasodilator actions of isoflavonoids of Gegen on rat isolated basilar artery

Deng, Yan; Ng, E.S.K.; Yeung, John H.K.; Kwan, Yiu Wa; Lau, Clara Bik‐San; Koon, J.C.M.; Zhou, Limin; Zuo, Zhong; Leung, Ping Chung; Fung, Kwok‐Pui; Lam, F.

doi:10.1016/j.jep.2011.11.021

Cited by 40 publications

(22 citation statements)

References 32 publications

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“…The cerebral vasodilation mediated by puerarin was associated with both endothelium‐dependent and endothelium‐independent pathways. The endothelium‐dependent vasodilation induced by puerarin was related to NO production, whereas the endothelium‐independent relaxation involved the K + channels opening (Deng et al ., ).…”

Section: Pharmacological Actionsmentioning

confidence: 97%

Puerarin: A Review of Pharmacological Effects

Zhou

Zhang

Peng

2013

Phytotherapy Research

531

323

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Puerarin is the major bioactive ingredient isolated from the root of the Pueraria lobata (Willd.) Ohwi, which is well known as Gegen (Chinese name) in traditional Chinese medicine. As the most abundant secondary metabolite, puerarin was isolated from Gegen in the late 1950s. Since then, its pharmacological properties have been extensively investigated. It is available in common foods and is used in alternative medicine. It has been widely used in the treatment of cardiovascular and cerebrovascular diseases, diabetes and diabetic complications, osteonecrosis, Parkinson's disease, Alzheimer's disease, endometriosis, and cancer. The beneficial effects of puerarin on the various medicinal purposes may be due to its wide spectrum of pharmacological properties such as vasodilation, cardioprotection, neuroprotection, antioxidant, anticancer, antiinflammation, alleviating pain, promoting bone formation, inhibiting alcohol intake, and attenuating insulin resistance. However, the direct molecular mechanisms and targets remain unclear. This review provides a comprehensive summary of the pharmacological effects of puerarin.

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Section: Pharmacological Actionsmentioning

confidence: 97%

Puerarin: A Review of Pharmacological Effects

Zhou

Zhang

Peng

2013

Phytotherapy Research

531

323

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“…Daidzein (64) and Daidzin (65) possess a vasorelaxant action through opening of K + channels and inhibition of Ca 2+ influx in the vascular smooth muscle cells. This cerebral vasodilator activity may be beneficial to patients with obstructive cerebrovascular diseases [126].…”

Section: Flavonoids -From Biosynthesis To Human Healthmentioning

confidence: 99%

Isoflavonoids

Foudah¹,

Abdel-Kader²

2017

Flavonoids - From Biosynthesis to Human Health

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Isoflavonoids are interesting class of natural products due to their positive effects on human health. Isoflavonoids include isoflavones, isoflavanones, isoflavans, rotenoids and pterocarpans. Although they are reported from many plant families, most isoflavonoids are produced by the subfamily Papilionaceae of the Fabaceae. Various chromatographic methods have been applied for the purification of isoflavonoids. Simple Ultra Violet (UV) absorption spectra as well as both One and two dimensional NMR (1D-and 2D-NMR) are critical for the identification of isoflavonoids. Each class of isoflavonoids has its unique feature in both 1 H-and 13 C-NMR that enable their proper characterization. High Resolution Mass Spectrometry (HRMS) is a substantial tool in such challenge. In vitro experiments indicated that isoflavonoids possess antioxidant, antimutagenic, antiproliferative as well as cancer preventive effects. Epidemiological studies provide support for some of these effects on human. Members of this class also are reported to have antimicrobial activity. In this chapter, isoflavones, isoflavanones, isoflavans, homoisoflavonoids and isoflavenes will be discussed in relation to their occurrence, methods of purification, spectral characters helpful in structure elucidation as well as their biological importance.

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“…Vascular protection, smooth muscle relaxation: D&G was found to dilate ex-vivo aortic rings of rat [30]; helped to repair balloon-injured arterial intima [17]; supported viability of myocardium [33]; lowered blood pressure in hypertensive rats [34] and maintained better survival of brain tissues under the adverse effects of middle-cerebral artery occlusion [35,36].…”

Section: Pharmacological Testsmentioning

confidence: 99%

Methodology for the Development of Evidence-based Herbal Tonics for Preventive Purposes

Leung¹

2015

ACIM

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Health supplements have special claims on common areas of health concern. The claims are usually supported only with traditional practices and common beliefs. In the current era of evidence-based practices, one would expect serious commitments, using modern research technologies, on the scientific explorations on the efficacies of the supplements. On the other hand, since health supplements carry the role of disease prevention and health maintenance, they should not be expected to go through strict assessment procedures like pharmaceuticals.The research development of a specific health supplement requires that the best available quality of herbs is used and their mechanism of action, not only limited to laboratory data, but also clinical evidences is worked out.

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Mechanisms of the cerebral vasodilator actions of isoflavonoids of Gegen on rat isolated basilar artery

Cited by 40 publications

References 32 publications

Puerarin: A Review of Pharmacological Effects

Puerarin: A Review of Pharmacological Effects

Isoflavonoids

Methodology for the Development of Evidence-based Herbal Tonics for Preventive Purposes

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