Mechanisms of the Effects of Granulocytic CSF on Tissue Reparation during Chronic CCl4-Induced Damage to the Liver

Abstract

Hepatoprotective effects of granulocytic CSF were studied using experimental model of CCl4-induced hepatitis. It was found that treatment with granulocytic CSF increased the content of stromal precursors and mesenchymal stem cells in the bone marrow and peripheral blood with subsequent increase in the number of hepatic precursor cells in the liver. These findings attest to mobilization of progenitor mesenchymal cells and their migration into damages liver tissue, which accelerates its regeneration related to changes in the parenchyma, but not connective tissue development.

RETRACTED ARTICLE: Ang II-AT2R increases mesenchymal stem cell migration by signaling through the FAK and RhoA/Cdc42 pathways in vitro

“…A prerequisite for these cells to participate in tissue repair is migration of injected MSCs to the damaged tissues [2]. When injected intravenously, MSCs appear to preferentially home to sites of injury [3], which has been observed in tissue injuries that occur in the bone [4], liver [5], brain [6], and heart [7]. However, mechanisms regarding how MSCs migrate into the injured tissue remain unknown.…”

High Mobility Group Box 1 Protein Inhibits the Proliferation of Human Mesenchymal Stem Cells and Promotes Their Migration and Differentiation along Osteoblastic Pathway

“…Interestingly, MSCs in the marrow cavity and compact bone migrate toward the arthrosynovial membrane in the very early developmental stage of collageninduced arthritis (CIA) in mice [33], an experimental model of human RA in which HMGB1 has been identi ed as a central pathogenic cytokine [3,17]. MSCs migration has also been observed in tissue injuries occurred in the bone [34], liver [35], brain [36], and heart [37]. Furthermore, a recent report demonstrated that MSCs express all the known receptors for HMGB1, including receptor for advanced glycation end products (RAGE), toll-like receptor 2 (TLR-2) and TLR-4 [38].…”

The influence of locally applied granulocyte‐colony stimulating factor on osteoporotic bone

“…As a hematopoietic growth factor, G‐CSF has shown its capability in recruiting BM stem cells to injured organs (Sotnikova et al. ; Yannaki et al. ; Solaroglu et al.…”

“…As a hematopoietic growth factor, G-CSF has shown its capability in recruiting BM stem cells to injured organs (Sotnikova et al 2005;Yannaki et al 2005;Solaroglu et al 2007) and bone defects (Ishida et al 2010). Particularly, it is reported that G-CSF was capable of mobilizing HSCs, EPCs (Minamino et al 2002), and mesenchymal stem cells (MSCs) (Deng et al 2011), which help to create an appropriate environment for bone formation by stimulating angiogenesis and osteogenesis.…”