Mechanisms of the immune response cause by cationic and anionic surface functionalized cellulose nanocrystals using cell-based assays

Despres, Hannah W; Sabra, Adham; Anderson, Phil; Hemraz, Usha D.; Boluk, Yaman; Sunasee, Rajesh; Ckless, Karina

doi:10.1016/j.tiv.2018.12.009

Cited by 30 publications

(18 citation statements)

References 45 publications

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“…In another study comparing cationic (poly(APMA)) and an anionic (poly(NIPAAm)) functionalized CNCs, the cationic induced a more robust immune response associated to NLRP3-inflammasome activation and increased levels of IL-1b in murine macrophages, mainly through decreased mitochondrial membrane polarization and decreased intracellular ATP. The anionic CNC induced unspecific immunological effects, either NLRP3-dependent or independent, leading to greater amounts of mitochondrialderived ROS and an endoplasmatic reticulum stress response (Despres et al 2019).…”

Section: Cellulose Nanocrystals (Cncs)mentioning

confidence: 99%

On the toxicity of cellulose nanocrystals and nanofibrils in animal and cellular models

et al. 2020

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The need for reaching environmental sustainability encourages research on new cellulosebased materials for a broad range of applications across many sectors of industry. Cellulosic nanomaterials obtained from different sources and with different functionalization are being developed with the purpose of its use in many applications, in pure and composite forms, from consumer products to pharmaceutics and healthcare products. Based on previous knowledge about the possible adverse health effects of other nanomaterials with high aspect ratio and biopersistency in body fluids, e.g., carbon nanotubes, it is expected that the nanometric size of nanocellulose will increase its toxicity as compared to that of bulk cellulose. Several toxicological studies have been performed, in vitro or in vivo, with the aim of predicting the health effects caused by exposure to nanocellulose. Ultimately, their goal is to reduce the risk to humans associated with unintentional environmental or occupational exposure, and the design of safe nanocellulose materials to be used, e.g., as carriers for drug delivery or other biomedical applications, as in wound dressing materials. This review intends to identify the toxicological effects that are elicited by nanocelluloses produced through a topdown approach from vegetal biomass, namely, cellulose nanocrystals and nanofibrils, and relate them with the physicochemical characteristics of nanocellulose. For this purpose, the article provides: (i) a brief review of the types and applications of cellulose nanomaterials; (ii) a comprehensive review of the literature reporting their biological impact, alongside to their specific physicochemical characteristics, in order to draw conclusions about their effects on human health.Célia Ventura and Fátima Pinto have contributed equally to this work.

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Section: Cellulose Nanocrystals (Cncs)mentioning

confidence: 99%

On the toxicity of cellulose nanocrystals and nanofibrils in animal and cellular models

et al. 2020

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“…This dual-function curcumin liposome scaffold can efficiently remove OS cells and promote the adhesion, proliferation, and differentiation of healthy bone cells in the porous scaffold, providing a promising therapeutic strategy for the treatment of bone defects after tumor resection. Despres et al found that the surface charge of liposome NPs can affect the immune response (39). Villegas et al also reported that liposome NPs are easily phagocytosed by mononuclear macrophages and have low stability in serum protein and in vivo (40).…”

Section: Liposomesmentioning

confidence: 99%

“…Despres et al. found that the surface charge of liposome NPs can affect the immune response ( 39 ). Villegas et al.…”

Section: Research Advances In Nanoplatforms For the Treatment Of Osmentioning

confidence: 99%

Recent Advances in Nanoplatforms for the Treatment of Osteosarcoma

et al. 2022

Front. Oncol.

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Osteosarcoma (OS) is the most common primary bone tumor in children and young people. Traditional surgical excision combined with chemotherapy presents many limitations, such as resistance and systemic side effects of chemotherapy drugs, postoperative recurrence, and bone defects. Given these limitations, novel therapeutic modalities for OS treatment using nanometer-sized platform-based chemotherapeutic delivery have emerged as a promising alternative therapy. This form of therapy offers multiple advantages, such as accurate delivery of the drug to the tumor site and repair of limited bone defects after tumor resection. In this review, we briefly summarize nanoplatforms, including liposomes, polymeric nanoparticles, inorganic nanoparticles, nanomicelles, dendrimers, nanocapsules, and exosomes. The essential shortcomings involved in these nanoplatforms, such as poor stability, immunogenicity, insufficient circulation, and drug leakage are also discussed, and related solutions are briefly proposed. Finally, the application prospects of nanoplatforms in the treatment of OS are discussed.

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“…The endoplasmic reticulum (ER), an integral and elaborate membrane organelle, has a powerful homeostatic system to achieve ER function that includes folding and modification of secretory proteins and synthesis of cholesterol and phospholipids [147]. However, when cells are stimulated by external factors (e.g., oxidative stress and ischemia reperfusion injury), ER homeostatic imbalance may occur, leading to endoplasmic reticulum stress (ERS) [148]. Furthermore, SiO 2 NP-induced ERS can further activate autophagy to reduce ER damage, a process known as ER autophagy [149].…”

Section: Endoplasmic Reticulum Impairmentmentioning

confidence: 99%

Nanomaterial-mediated autophagy: coexisting hazard and health benefits in biomedicine

Feng

Zhang

et al. 2020

Part Fibre Toxicol

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Background Widespread biomedical applications of nanomaterials (NMs) bring about increased human exposure risk due to their unique physicochemical properties. Autophagy, which is of great importance for regulating the physiological or pathological activities of the body, has been reported to play a key role in NM-driven biological effects both in vivo and in vitro. The coexisting hazard and health benefits of NM-mediated autophagy in biomedicine are nonnegligible and require our particular concerns. Main body We collected research on the toxic effects related to NM-mediated autophagy both in vivo and in vitro. Generally, NMs can be delivered into animal models through different administration routes, or internalized by cells through different uptake pathways, exerting varying degrees of damage in tissues, organs, cells, and organelles, eventually being deposited in or excreted from the body. In addition, other biological effects of NMs, such as oxidative stress, inflammation, necroptosis, pyroptosis, and ferroptosis, have been associated with autophagy and cooperate to regulate body activities. We therefore highlight that NM-mediated autophagy serves as a double-edged sword, which could be utilized in the treatment of certain diseases related to autophagy dysfunction, such as cancer, neurodegenerative disease, and cardiovascular disease. Challenges and suggestions for further investigations of NM-mediated autophagy are proposed with the purpose to improve their biosafety evaluation and facilitate their wide application. Databases such as PubMed and Web of Science were utilized to search for relevant literature, which included all published, Epub ahead of print, in-process, and non-indexed citations. Conclusion In this review, we focus on the dual effect of NM-mediated autophagy in the biomedical field. It has become a trend to use the benefits of NM-mediated autophagy to treat clinical diseases such as cancer and neurodegenerative diseases. Understanding the regulatory mechanism of NM-mediated autophagy in biomedicine is also helpful for reducing the toxic effects of NMs as much as possible.

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Mechanisms of the immune response cause by cationic and anionic surface functionalized cellulose nanocrystals using cell-based assays

Cited by 30 publications

References 45 publications

On the toxicity of cellulose nanocrystals and nanofibrils in animal and cellular models

On the toxicity of cellulose nanocrystals and nanofibrils in animal and cellular models

Recent Advances in Nanoplatforms for the Treatment of Osteosarcoma

Nanomaterial-mediated autophagy: coexisting hazard and health benefits in biomedicine

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