2007
DOI: 10.1038/sj.onc.1210431
|View full text |Cite
|
Sign up to set email alerts
|

Mechanisms of translational deregulation in human tumors and therapeutic intervention strategies

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

5
64
0

Year Published

2007
2007
2014
2014

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 73 publications
(69 citation statements)
references
References 165 publications
(180 reference statements)
5
64
0
Order By: Relevance
“…It is now clear that deregulated protein synthesis plays an important role in human cancer (28). RNA Pol III transcription is elevated in a broad range of transformed cell lines and in human tumors (46), and both qualitative and quantitative changes in protein synthesis are seen as a result of the loss of PTEN and the activation of mTOR (1). The lipid phosphatase activity of PTEN antagonizes the activity of PI3K in the cytoplasm and plays a critical role in the tumor suppressor function of PTEN.…”
Section: Discussionmentioning
confidence: 99%
“…It is now clear that deregulated protein synthesis plays an important role in human cancer (28). RNA Pol III transcription is elevated in a broad range of transformed cell lines and in human tumors (46), and both qualitative and quantitative changes in protein synthesis are seen as a result of the loss of PTEN and the activation of mTOR (1). The lipid phosphatase activity of PTEN antagonizes the activity of PI3K in the cytoplasm and plays a critical role in the tumor suppressor function of PTEN.…”
Section: Discussionmentioning
confidence: 99%
“…Translational control is a critical target of common oncogenes and tumor suppressors (reviewed in detail by Bilanges and Stokoe (Bilanges and Stokoe, 2007)). Interestingly, ribosomal proteins associated with Diamond-Blackfan anemia and (del)5 or 5q-MDS have been proposed to function in p53 activation in response to nucleolar stress.…”
Section: Rps14: a Role For Defective Translation In Mds?mentioning
confidence: 99%
“…The identification of large intronic BCL2 deletions in two cell lines that also harbor IGH@-BCL2 rearrangements suggests that such deletions might confer a growth or survival advantage, perhaps by shortening unspliced BCL2 transcripts and/or enhancing BCL2 mRNA stability or translational initiation. 65,66 Further studies are warranted to determine the frequency and significance of such BCL2 deletions in primary tumors and to look for analogous deletions in association with other translocations.…”
Section: Discussionmentioning
confidence: 99%