2020
DOI: 10.3390/cells9051297
|View full text |Cite
|
Sign up to set email alerts
|

Mechanisms Regulating Muscle Regeneration: Insights into the Interrelated and Time-Dependent Phases of Tissue Healing

Abstract: Despite a massive body of knowledge which has been produced related to the mechanisms guiding muscle regeneration, great interest still moves the scientific community toward the study of different aspects of skeletal muscle homeostasis, plasticity, and regeneration. Indeed, the lack of effective therapies for several physiopathologic conditions suggests that a comprehensive knowledge of the different aspects of cellular behavior and molecular pathways, regulating each regenerative stage, has to be still devise… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

3
191
1

Year Published

2020
2020
2024
2024

Publication Types

Select...
9

Relationship

1
8

Authors

Journals

citations
Cited by 162 publications
(195 citation statements)
references
References 178 publications
3
191
1
Order By: Relevance
“…The outcomes included a significant increase in muscle strength and an increase in the number and size of fast myofibers, that are the first to respond to electrical stimulation and whose content and size are correlated to muscle strength. In muscle biopsies, Pax7- and NCAM-positive muscle satellite cells were also increased in the absence of muscle damage and cellular inflammation [ 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 ]. Finally, there are many applications of in-home or in-hospital functional electrical stimulation managements of disuse muscle atrophy related to organ diseases, from chronic cardiovascular failures to functional electrostimulation cycling in SCI [ 52 , 53 , 54 , 55 , 56 ].…”
Section: Byproductsmentioning
confidence: 99%
“…The outcomes included a significant increase in muscle strength and an increase in the number and size of fast myofibers, that are the first to respond to electrical stimulation and whose content and size are correlated to muscle strength. In muscle biopsies, Pax7- and NCAM-positive muscle satellite cells were also increased in the absence of muscle damage and cellular inflammation [ 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 ]. Finally, there are many applications of in-home or in-hospital functional electrical stimulation managements of disuse muscle atrophy related to organ diseases, from chronic cardiovascular failures to functional electrostimulation cycling in SCI [ 52 , 53 , 54 , 55 , 56 ].…”
Section: Byproductsmentioning
confidence: 99%
“…Myoblasts subsequently proliferate, migrate, differentiate, and fuse to form multinucleated muscle fibres to repair damaged myofibrils or form new myofibrils [ 4 , 5 ]. The process of muscle regeneration, from satellite cell activation to fibre repair, is finely regulated by transcription factors, such as Pax7 and Pax3, and by myogenic regulatory factors including MyoD, Myf5, Myf6, and myogenin, which are expressed in a coordinated fashion and modulated by diverse inflammatory mediators, such as cytokines and prostaglandins [ 5 , 6 ].…”
Section: Introductionmentioning
confidence: 99%
“…These events lead to a weak regeneration and formation of fibrotic scar tissue, and result in loss of functional muscle mass. Consequently, the ability to perform intense muscular efforts and even easy, daily-life tasks may be impaired [ 222 , 223 , 224 ].…”
Section: Mammals: Cell Therapy For Skeletal Muscle Regenerationmentioning
confidence: 99%