Mechanisms through which sulfur amino acids control protein metabolism and oxidative status

Métayer, Sonia; Seiliez, Iban; Collin, Anne; Duchêne, Sophie; Mercier, Yves; Geraert, P. A.; Tesseraud, Sophie

doi:10.1016/j.jnutbio.2007.05.006

Cited by 232 publications

(162 citation statements)

References 90 publications

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“…Methionine participates in methyl group metabolism and the synthesis of other S amino acids, notably Cys. Cysteine is required for the synthesis of GSH and taurine, which are important compounds for host defense against oxidative stress (Métayer et al, 2008). This current study showed that increasing Met supplementation in the maternal diet decreased the GSH-Px activity in both the yolk and the albumen of the eggs.…”

Section: Protein Oxidationsupporting

confidence: 57%

Effect of Maternal Selenium and Methionine on Poultry Products (Egg and Meat) Qualities and Oxidative Stability

Wu¹,

Pan²,

Wang³

et al. 2011

Soybean and Nutrition

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Section: Protein Oxidationsupporting

confidence: 57%

Effect of Maternal Selenium and Methionine on Poultry Products (Egg and Meat) Qualities and Oxidative Stability

Wu¹,

Pan²,

Wang³

et al. 2011

Soybean and Nutrition

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“…Thus, we cannot exclude the possibility that methionine, through the conversion to SAM, regulates Na/K-ATPase-mediated blastocoelic cavitation, as suggested by Bonilla et al [9]. Furthermore, the impaired blastocyst development induced by ethionine was not completely recovered by SAM, suggesting that SAM-independent roles of methionine such as a source of protein synthesis are also important in bovine blastocyst development [1,2]. Importantly, the results of the present study indicate that disruption of methionine metabolism is critical for development after zygotic gene activation (ZGA), which is considered to occur at the 8-cell stage in the case of bovine [39,40].…”

Section: Discussionmentioning

confidence: 78%

“…Dev. 58: [91][92][93][94][95][96][97] 2012) M ethionine is a dietary essential amino acid that plays multiple biological roles, including those as the initiating amino acid in eukaryotic protein synthesis, a precursor of the essential methyl donor for methylation reactions (S-adenosylmethionine, SAM) and a source of redox regulators (cysteine and glutathione) [1,2]. Methionine metabolism can be seen as the trans-and remethylation cycle of methionine (methionine cycle) that intertwines with the cycle of folate metabolism (folate cycle) and the transsulfuration pathway from homocysteine, an intermediate in the methionine cycle [3], and these combined metabolic networks are called one-carbon metabolism [4,5].…”

mentioning

confidence: 99%

Importance of Methionine Metabolism in Morula-to-blastocyst Transition in Bovine Preimplantation Embryos

Ikeda

Sugimoto

Kume

2012

Journal of Reproduction and Development

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Abstract. The roles of methionine metabolism in bovine preimplantation embryo development were investigated by using ethionine, an antimetabolite of methionine. In vitro produced bovine embryos that had developed to the 5-cell stage or more at 72 h after the commencement of in vitro fertilization (IVF) were then cultured until day 8 (IVF = day 0) in medium supplemented with 0 (control), 1, 5 and 10 mM ethionine. Compared with the blastocyst development in the control (40.0%), ethionine at 10 mM almost completely blocked blastocyst development (1.1%, P<0.001), and this concentration was used in the following experiments. Methionine added at the same concentration (10 mM, a concentration control of ethionine) did not cause such an intense developmental inhibition. Development to the compacted morula stage on day 6 was not affected by 10 mM ethionine treatment. S-adenosylmethionine (SAM) added to the ethionine treatment partly restored the blastocyst development. Semiquantitative reverse transcription-polymerase chain reaction analysis of cell lineage-related transcription factors in day 6 compacted morulae showed that the expressions of NANOG and TEAD4 were increased by ethionine treatment relative to the control (P<0.01). Furthermore, immunofluorescence analysis of 5-methylcytosine revealed that DNA was hypomethylated in the ethionine-treated day 6 morulae compared with the control (P<0.001). These results demonstrate that the disruption of methionine metabolism causes impairment of the morula-toblastocyst transition during bovine preimplantation development in part via SAM deficiency, indicating the indispensable roles of methionine during this period. The disruption of methionine metabolism may cause hypomethylation of DNA and consequently lead to the altered expression of developmentally important genes, which then results in the impairment of blastocyst development. Key words: Bovine, Methionine, One-carbon metabolism, Preimplantation embryo, S-adenosylmethionine (J. Reprod. Dev. 58: [91][92][93][94][95][96][97] 2012) M ethionine is a dietary essential amino acid that plays multiple biological roles, including those as the initiating amino acid in eukaryotic protein synthesis, a precursor of the essential methyl donor for methylation reactions (S-adenosylmethionine, SAM) and a source of redox regulators (cysteine and glutathione) [1,2]. Methionine metabolism can be seen as the trans-and remethylation cycle of methionine (methionine cycle) that intertwines with the cycle of folate metabolism (folate cycle) and the transsulfuration pathway from homocysteine, an intermediate in the methionine cycle [3], and these combined metabolic networks are called one-carbon metabolism [4,5]. Recently, mammalian oocytes and preimplantation embryos have been reported to express the key regulatory enzymes in one-carbon metabolism [6][7][8], suggesting that mammalian oocytes and preimplantation embryos can independently utilize and metabolize nutrients in one-carbon metabolism, such as methionine, choline, betaine, folates a...

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“…Protein deposition corresponds to the positive balance between protein synthesis and breakdown (Metayer et al, 2008). In an effort to maximize the protein deposition and optimize nutrient utilization in pig nutrition, it is necessary to determine the amino acid requirement for protein deposition in each growth stage.…”

Section: Introductionmentioning

confidence: 99%

Nutritional plans of digestible lysine for growing-finishing gilts

et al. 2014

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-This experiment was conducted to evaluate nutritional plans of digestible lysine (DLys) for growingfinishing gilts. Eighty gilts with 63 days of age and an initial weight of 24.2±1.52 kg were distributed in a completely randomized block design, with five nutritional plans of DLys (9-8-7, 10-9-8, 11-10-9, 12-11-10, and 13-12-11 g/kg, from 63 to 103, 104 to 133, and 134 to 153 days of age, respectively) and eight replicates. Pigs were housed in pairs and fed their respective diets ad libitum throughout the experimental period (90 days). To monitor the animal development along the experiment at 103 and 133 days, gilts were weighed and subjected to analysis of ultrasound for evaluation of loin depth (longissimus dorsi) and backfat thickness. At the end of the experiment (153 days of age) the animals were weighed, and after slaughter carcasses were evaluated individually using a typifying pistol to evaluate the percentage and the content of carcass meat, loin depth and backfat thickness. From 63 to 133 days, there was no effect of the nutritional plans on daily feed intake, performance, or backfat thickness; however the loin depth was greater in the gilts that received plans with high levels of DLys (12-11; 13-12 g/kg) compared with the plan with the lowest level (8-7 g/kg). For the entire period (63 to 153 days), no influence of the nutritional plans was observed on the daily feed intake, performance variables, or carcass characteristics. A nutritional plan containing 9-8-7 g/kg of digestible lysine fed from 63 to 103, 104 to 133 and 134 to 153 days, respectively, meets the requirements for performance and carcass characteristics of growing-finishing gilts.

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Mechanisms through which sulfur amino acids control protein metabolism and oxidative status

Cited by 232 publications

References 90 publications

Effect of Maternal Selenium and Methionine on Poultry Products (Egg and Meat) Qualities and Oxidative Stability

Effect of Maternal Selenium and Methionine on Poultry Products (Egg and Meat) Qualities and Oxidative Stability

Importance of Methionine Metabolism in Morula-to-blastocyst Transition in Bovine Preimplantation Embryos

Nutritional plans of digestible lysine for growing-finishing gilts

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