Mechanistic evaluation of gastroprotective effects of Kangfuxin on ethanol-induced gastric ulcer in mice

KangFuXin Liquid in the Treatment of Diabetic Foot Ulcer: A Systematic Review and Meta-Analysis

“…KFXL is rich in active substances such as sex pheromones, proteins, amino acids, affinity peptides, alkaloids, adipokinetic hormones, and polysaccharides, which can reduce inflammatory factor, such as IL-6, IL-8, TNF-a, and c-reactive protein, increase CD8+ T-cell activity and SOD content, increase EGF and VEGF in wound tissue, and TGF-β and bFGF levels [31][32][33][34][35][36]. Recent studies have shown that the mechanism of wound healing from the Periplaneta americana extract may be through the regulation of JAK/STAT3, PI3K/AKT, nuclear factor kappa B canonical pathway, and extracellular signal-regulated kinas signaling to affect cell proliferation, fibrogenesis, re-epithelialization, and remodeling [13,14,37]. At the same time, the compound periplanosides A-C can stimulate the production of human epidermal fibroblast collagen at a certain concentration [38].…”

“…It has been used for thousands of years to treat snake bites, skin ulcers, and burns. Pharmacological research shows KFXL can enhance immunity, reduce inflammation, promote epidermal cell growth, granulation tissue proliferation to repair the damage, and accelerating the repair and regeneration of damaged tissue to promote wound healing [9][10][11][12][13][14][15]. In China, this pure traditional Chinese medicine extract has been widely used in the clinical treatment of DFU.…”

Periplaneta americana Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Rats by Keap1/Nrf-2 Activation, Intestinal Barrier Function, and Gut Microbiota Regulation

“…Periplaneta americana , more widely known as American cockroach, was first recorded in an ancient Chinese pharmacopeia “ Shen Nong Ben Cao Jing .” As one of the largest and oldest insect groups being present for over 300 million years, this miraculous insect has also been employed as a traditional Chinese medicine for over 2,000 years, for its functions of activating blood circulation, dissipating blood stasis, promoting digestion, and inducing diuresis. Modern studies have revealed its various bioactivities ( Srivastava et al, 2011 ; Zhang et al, 2013 ; Huang et al, 2017a ; Shen et al, 2017 ; Zhao et al, 2017 ) such as gastric protection, wound healing, antitumor activity, immune enhancement, liver protection, and antiviral effect. P. americana has been developed into clinical drugs under the approval of China Food and Drug Administration (CFDA), such as “ Kangfuxin oral liquid (Z51021834),” “ Xinmainong injection (Z20060443),” and “ Ganlong capsule (Z20050113).” Particularly, Kangfuxin oral liquid, which is prepared by the ethanol extract of P. americana , has been widely demonstrated for its wound healing effect in peptic ulcer treatment ( Chen et al, 2016 ; Shen et al, 2017 ).…”

“…Modern studies have revealed its various bioactivities ( Srivastava et al, 2011 ; Zhang et al, 2013 ; Huang et al, 2017a ; Shen et al, 2017 ; Zhao et al, 2017 ) such as gastric protection, wound healing, antitumor activity, immune enhancement, liver protection, and antiviral effect. P. americana has been developed into clinical drugs under the approval of China Food and Drug Administration (CFDA), such as “ Kangfuxin oral liquid (Z51021834),” “ Xinmainong injection (Z20060443),” and “ Ganlong capsule (Z20050113).” Particularly, Kangfuxin oral liquid, which is prepared by the ethanol extract of P. americana , has been widely demonstrated for its wound healing effect in peptic ulcer treatment ( Chen et al, 2016 ; Shen et al, 2017 ). In view of its significant role in gastric protection, Li et al (2016) has been demonstrated for the therapeutic effects of P. americana in UC rats induced by dinitrochlorobenzene and acetic acid, which are attributed to the anti-inflammation function and fibroblasts viability.…”

Protective Effect of Ocotillol, the Derivate of Ocotillol-Type Saponins in Panax Genus, against Acetic Acid-Induced Gastric Ulcer in Rats Based on Untargeted Metabolomics

“…It is a kind of precancerous gastric cancer disease and plays a vital role in the occurrence and process of intestinal-type gastric cancer [1,2]. The main reasons for GU formation include infection of Helicobacter pylori bacteria, gastric hyperacidity, local ischemia or damaged barrier effect of the gastric mucosa [3]. The ultimate formation of a gastric ulcer is due to the digestion of gastric acid and pepsin, and gastric acid is the decisive factor for the occurrence of the ulcer.…”