Mechanistic insight into the evaporative crystallization of two polymorphs of nitrofurantoin monohydrate

Tian, Fang; Qu, Haiyan; Louhi-Kultanen, Marjatta; Rantanen, Jukka

doi:10.1016/j.jcrysgro.2009.02.004

Cited by 23 publications

(25 citation statements)

References 38 publications

(37 reference statements)

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“…NF belongs to a biopharmaceutical classification system (BCS) antibiotic drug, and has both low solubility and permeability problems [7][8][9]. The physicochemical properties, such as the dissolution rate, aqueous solubility, stability, and bioavailability of NF in commercial tablets would decrease due to its polymorphic transformation or photo-degradation during its storage under different extraneous conditions [7,8].…”

Section: Introductionmentioning

confidence: 99%

Raman and Terahertz Spectroscopic Investigation of Cocrystal Formation Involving Antibiotic Nitrofurantoin Drug and Coformer 4-aminobenzoic Acid

Cai

Xue

et al. 2016

Crystals

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Cocrystallization could improve most physicochemical properties of specific active pharmaceutical ingredients, which has great potential in pharmaceutical development. In this study, the cocrystal of nitrofurantoin and 4-aminobenzoic acid was prepared with solid-state (solvent-free or green-chemistry) grinding approach, and the above cocrystal has been characterized by Raman and terahertz vibrational spectroscopic techniques. Spectral results show that the vibrational modes of the cocrystal within the whole spectral region are different from those of the corresponding parent materials. The dynamic process of such pharmaceutical cocrystal formation has also been monitored directly with Raman spectra. These results offer us unique means for characterizing the cocrystal conformation from the molecule-level, and provides us with rich information about the reaction dynamic of cocrystal formation within pharmaceutical fields.

show abstract

Section: Introductionmentioning

confidence: 99%

Raman and Terahertz Spectroscopic Investigation of Cocrystal Formation Involving Antibiotic Nitrofurantoin Drug and Coformer 4-aminobenzoic Acid

Cai

Xue

et al. 2016

Crystals

View full text Add to dashboard Cite

show abstract

“…NF belongs to a biopharmaceutical classification system (BCS) class II antibiotic drug, and has both low solubility and permeability problems [7][8][9][10]. The physicochemical properties, such as the dissolution rate, aqueous solubility, stability and bioavailability of NF in commercial tablets would decrease during its storage under different extraneous conditions [7,8].…”

Section: Introductionmentioning

confidence: 99%

Raman and Terahertz Spectroscopic Investigation of Cocrystal Formation Involving Antibiotic Nitrofurantoin Drug and Coformer 4-aminobenzoic Acid

Cai

Xue

et al. 2016

Preprint

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Cocrystallizaiton could improve most physicochemical properties of specific active pharmaceutical ingredients, which has great potential in pharmaceutical development. In this study, the cocrystal of nitrofurantoin and 4-aminobenzoic acid was prepared with solid-state (solvent-free or green-chemistry) grinding approach, and the above cocrystal has been characterized by Raman and terahertz vibrational spectroscopic techniques. Spectral results show that the vibrational modes of the cocrystal within the whole spectral region are different from those of the corresponding parent materials. The dynamic process of such pharmaceutical cocrystal formation has also been monitored directly with Raman spectra. These results offer us unique means for characterizing the cocrystal conformation from molecule-level and also provide us rich information about the reaction dynamic of cocrystal formation within pharmaceutical fields.

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“…The supersaturation of the drug solution can be achieved by removal of some of solvent (Mullin, 1995). The evaporation can be performed by various methods, e.g., fusion-cooling, spray-drying, rotary evaporation, lyophilization and evaporation in ambient conditions (Priyanka et al, 2008;Tian et al, 2009;Elgindy et al, 2010). Vacuum evaporation can reduce pressure in a liquid-filled container to be below the vapor pressure of the liquid, causing the liquid to evaporate at a lower temperature than normal.…”

Section: Introductionmentioning

confidence: 99%

“…However, the polymorphic form of drugs can be changed after the crystallization using some additives (Tian et al, 2009). In this study, the evaporative recrystallization using rotary evaporation and lyophilization methods were demonstrated and used for preparing amorphous form of ITZ, without carrier, in order to improve dissolution of the drug.…”

Section: Introductionmentioning

confidence: 99%

Particle design of itraconazole by evaporative recrystallization for dissolution improvement

Sriamornsak¹,

Burapapadh²

2015

Chemical Engineering Research and Design

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Mechanistic insight into the evaporative crystallization of two polymorphs of nitrofurantoin monohydrate

Cited by 23 publications

References 38 publications

Raman and Terahertz Spectroscopic Investigation of Cocrystal Formation Involving Antibiotic Nitrofurantoin Drug and Coformer 4-aminobenzoic Acid

Raman and Terahertz Spectroscopic Investigation of Cocrystal Formation Involving Antibiotic Nitrofurantoin Drug and Coformer 4-aminobenzoic Acid

Raman and Terahertz Spectroscopic Investigation of Cocrystal Formation Involving Antibiotic Nitrofurantoin Drug and Coformer 4-aminobenzoic Acid

Particle design of itraconazole by evaporative recrystallization for dissolution improvement

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