Mechanoregulation of human articular chondrocyte aggrecan and type II collagen expression by intermittent hydrostatic pressure in vitro

Ikenoue, Takashi; Trindade, Michael C. D.; Lee, Mel S.; Lin, Eric Y; Schurman, David J.; Goodman, Stuart B.; Smith, Robert L.

doi:10.1016/s0736-0266(02)00091-8

Cited by 194 publications

(138 citation statements)

References 59 publications

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“…The contrasting results for the healthy knee and the osteoarthritic knee suggest that healthy cartilage responds positively to load, whereas degraded cartilage in osteoarthritic knees responds negatively to load. The response of healthy cartilage to load is consistent with the findings of experimental and theoretical studies, which suggest that load can produce an adaptive response (thickening and enhanced mechanical properties) 5,[14][15][16] . The The adduction moment at the knee is associated with the medial-to-lateral load distribution at the knee.…”

Section: Cartilage Morphology and Walking Mechanicssupporting

confidence: 85%

Gait Mechanics Influence Healthy Cartilage Morphology and Osteoarthritis of the Knee

Andriacchi

Koo

Scanlan

2009

Journal of Bone and Joint Surgery

407

366

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The response of healthy and diseased cartilage of the knee to the mechanics of walking is examined, with the goal of providing insight into the relationship between the kinematics and kinetics of the knee during walking and the maintenance of cartilage health. The combination of information from three-dimensional thickness models of cartilage derived from magnetic resonance imaging and the analysis of the interaction between load at the knee and kinematic changes during walking associated with loss of the anterior cruciate ligament demonstrated the importance of considering walking mechanics as an important factor in the initiation and progression of osteoarthritis. In particular, this material suggests that knee cartilage becomes conditioned to loading and to the large number of repetitive cycles of loading that occur during walking and that healthy cartilage homeostasis is maintained as long as there are no changes to the normal patterns of locomotion, the structure of the knee joint, or cartilage biology. Thus, there is the potential for a degenerative pathway to be initiated when a condition such as anterior cruciate ligament injury causes the repetitive loading during walking to shift to a new location. The sensitivity of cartilage to the kinematic changes is illustrated with the anterior cruciate ligament-deficient knee and the regional variations in cartilage morphology. The material presented here supports the conclusion that individual variations in the range of loading and kinematics at the knee during walking can have a profound influence on the initiation and progression of osteoarthritis of the knee.

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Section: Cartilage Morphology and Walking Mechanicssupporting

confidence: 85%

Gait Mechanics Influence Healthy Cartilage Morphology and Osteoarthritis of the Knee

Andriacchi

Koo

Scanlan

2009

Journal of Bone and Joint Surgery

407

366

View full text Add to dashboard Cite

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“…(27,28)] on the pressures and pressure-time cycles cartilage experience in life are essential to understanding the etiology of osteoarthritis, as in research on the influence of pressure at matrix, cellular, and subcellular scales (8,56,57). These in vivo pressures also define the pressure environment that proposed augmentations to, and substitutions for, natural cartilage must endure for the subsequent life of the joint.…”

Section: Discussionmentioning

confidence: 99%

“…Again quoting from the web page of the National Institute of Arthritis and Musculoskeletal and Skin Diseases (3): ''Mechanical load across joints is critically important for the maintenance of cartilage, and abnormal mechanical loading of joints can lead to pathological conditions.' ' Thus, cartilage cells (chondrocytes) appear to depend on the mechanical environment to control their function as well as to transport nutrients and metabolites (6)(7)(8)(9). The pressures on and in cartilage are the manifestation of the applied load in the environment of the cartilage matrix.…”

mentioning

confidence: 99%

Corroboration of in vivo cartilage pressures with implications for synovial joint tribology and osteoarthritis causation

Morrell

Hodge

Krebs

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

104

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Pressures on normal human acetabular cartilage have been collected from two implanted instrumented femoral head hemiprostheses. Despite significant differences in subjects' gender, morphology, mobility, and coordination, in vivo pressure measurements from both subjects covered similar ranges, with maximums of 5-6 MPa in gait, and as high as 18 MPa in other movements. Normalized for subject weight and height (nMPa), for free-speed walking the maximum pressure values were 25.2 for the female subject and 24.5 for the male subject. The overall maximum nMPa values were 76.2 for the female subject during rising from a chair at 11 months postoperative and 82.3 for the male subject while descending steps at 9 months postoperative. These unique in vivo data are consistent with corresponding cadaver experiments and model analyses. The collective results, in vitro data, model studies, and now corroborating in vivo data support the self-pressurizing ''weeping'' theory of synovial joint lubrication and provide unique information to evaluate the influence of in vivo pressure regimes on osteoarthritis causation and the efficacy of augmentations to, and substitutions for, natural cartilage.

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“…Cyclic compressive loading on articular cartilage enhances chondrocyte biosynthetic response and extracellular matrix production. [32][33][34][35][36][37] Moreover, cyclic compressive loading has chondroprotective effects. It inhibits the release of matrix metalloproteinase and proinflammatory mediators, such as interleukin (IL)-1β, IL-6, tumor necrosis factor-α, and monocyte chemoattractant protein-1.…”

Section: Fig 2 Long-term Effect (5 Participants)mentioning

confidence: 99%

Clinical Validation of Pain Management Manipulative Therapy for Knee Osteoarthritis With the Squeeze-Hold Technique: A Case Series

Nakajima

2017

Journal of Chiropractic Medicine

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Objective: The purpose of this case series was to describe the short-term and long-term clinical effects of a manual technique for treating osteoarthritis (OA) knee pain. Methods: This study measured of the immediate effect and long-term effect by using a case series of different groups of subjects. Knee OA and activity restriction in patients were evaluated by using the Kellgren-Lawrence (K/L) Grading Scale and the Japanese Knee Osteoarthritis Measure (JKOM) index. In the intervention, lower limb muscles were squeezed by hand for 20 seconds. Each squeeze was performed for both lower limbs. Passive range-of-motion (ROM) exercise was performed on the knee joint. In one set of cases, immediate effects were measured after a one-time treatment with pretreatment and posttreatment outcome measures. Eleven people with knee OA participated in the study. On a visual analogue scale (VAS) for pain, muscle stiffness, and muscular hemodynamics for estimation of muscle blood flow were recorded before and after the squeeze-hold treatment. In another set of cases, the treatment was given to all patients once a week for 6 months, and long-term effects were measured. Data on 5 subjects with knee OA were collected for 6 months after initial treatment. The VAS for pain and JKOM were recorded every month for 6 months. Results: For immediate effects, the VAS was 69 ± 21 mm before treatment and 26 ± 22 mm after treatment. Muscle stiffness was 8.8 ± 3.6 (absolute number) before treatment and 3.5 ± 2.1 after treatment. Tissue (muscle) oxygen saturation was 60.1 ± 5.7% before treatment and 65.3 ± 4.8% after treatment. Total hemoglobin was 24.3 ± 3.3 (absolute number) before treatment and 25 ± 2.3 after treatment. A tendency for reduction in OA knee pain and muscle stiffness was observed, and a tendency for increase was observed in the blood flow in the muscle. For long-term effects in all 5 participants (any K/L grade, any JKOM score), OA knee pain and JKOM score improved gradually through 6 months. Conclusions: The participants in this case series showed improvement in pain and function. These findings indicate the feasibility of a larger study on the squeeze-hold intervention for OA knee pain. (J Chiropr Med 2017;16:122-130)

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Mechanoregulation of human articular chondrocyte aggrecan and type II collagen expression by intermittent hydrostatic pressure in vitro

Cited by 194 publications

References 59 publications

Gait Mechanics Influence Healthy Cartilage Morphology and Osteoarthritis of the Knee

Gait Mechanics Influence Healthy Cartilage Morphology and Osteoarthritis of the Knee

Corroboration of in vivo cartilage pressures with implications for synovial joint tribology and osteoarthritis causation

Clinical Validation of Pain Management Manipulative Therapy for Knee Osteoarthritis With the Squeeze-Hold Technique: A Case Series

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