Search citation statements
Paper Sections
Citation Types
Year Published
Publication Types
Relationship
Authors
Journals
Cited by 8 publications
References 64 publications
The titin locus located on chromosome 2q24 in the human genome expresses about 100 kb full‐length mRNAs, that are translated into giant up to 34.350‐residue large polypeptides. Therefore, titin is by far the largest known protein. The titin protein is abundant in vertebrate muscles, where it spans half of the sarcomere. In situ , 1–2 μm long titin polypeptides establish a sarcomeric filament system that is critical for myofibrillar integrity and elasticity. Biomechanically, titin's intrinsic elasticity is fine‐tuned in the different muscle tissues through alternative splicing, post‐translational modifications and protein–protein interactions. Moreover, a plethora of molecular interactions with stress‐regulated ligands positions titin centrally in stretch‐dependent signalling in muscle. Therefore, mutations in this filament system are important causes of hereditary cardiomyopathies and muscular dystrophies. Key Concepts: Sarcomeres consist of precisely assembled proteins that together form the basic functional units of striated muscle and give rise to efficient and finely tuned contraction. In muscle tissues, 1–2 μm single titin polypeptide chains span half of the sarcomere. The intrasarcomeric filamentous titin protein provides sarcomeres with intrinsic elasticity and couples stretch‐dependent signalling together with muscle remodelling. Titin molecule is tailored to physiological requirements of different muscles through alternative splicing, post‐translational modifications and protein–protein interactions. Mutations in the titin gene are associated with different heart and skeletal muscle diseases.
The titin locus located on chromosome 2q24 in the human genome expresses about 100 kb full‐length mRNAs, that are translated into giant up to 34.350‐residue large polypeptides. Therefore, titin is by far the largest known protein. The titin protein is abundant in vertebrate muscles, where it spans half of the sarcomere. In situ , 1–2 μm long titin polypeptides establish a sarcomeric filament system that is critical for myofibrillar integrity and elasticity. Biomechanically, titin's intrinsic elasticity is fine‐tuned in the different muscle tissues through alternative splicing, post‐translational modifications and protein–protein interactions. Moreover, a plethora of molecular interactions with stress‐regulated ligands positions titin centrally in stretch‐dependent signalling in muscle. Therefore, mutations in this filament system are important causes of hereditary cardiomyopathies and muscular dystrophies. Key Concepts: Sarcomeres consist of precisely assembled proteins that together form the basic functional units of striated muscle and give rise to efficient and finely tuned contraction. In muscle tissues, 1–2 μm single titin polypeptide chains span half of the sarcomere. The intrasarcomeric filamentous titin protein provides sarcomeres with intrinsic elasticity and couples stretch‐dependent signalling together with muscle remodelling. Titin molecule is tailored to physiological requirements of different muscles through alternative splicing, post‐translational modifications and protein–protein interactions. Mutations in the titin gene are associated with different heart and skeletal muscle diseases.
The book "Mechanosensitivity in Cells and Tissues: Mechanical Stretch and Cytokines" edited by Andre Kamkin and Irina Kiseleva impressively demonstrates the diversity of cellular effects of cytokines depending on mechanical stimuli. Clinical and fundamental investigation of biological effects of cytokines in regulation of functioning of cells, tissues and organs is a relatively new, interesting and fast growing field, which draws a lot of attention recently. A proposed link between cytokines, their production and mechanisms of action, and their impact on effects of cellular and tissue stretch given a new momentum to this field. The role of cytokines as regulators of stretch related mechanisms is of special importance since mechanosensitivity plays an important role in a wide variety of biological processes. It is known that cytokines can be marked out as a new separate regulatory system which, along with nervous and endocrine systems, helps to maintain homeostasis, and these three systems are tightly interconnected and interdependent. Presently two major approaches to investigation of cytokines and mechanosensitivity exist. The first one focuses on the effects of interplay of mechanical stimulation of tissue or cells and cytokine production. The second approach investigates the influence of cytokines application on mechanosensitivity and mechanotransduction. This Volume is devoted to those two issues.To my knowledge Andre Kamkin and Irina Kiseleva present the first book on this topic, which consists of a collection of publications, written by leading scientists in this field, which guaranties that this Volume will remain of great interest to readers for a long period of time. Present book is devoted to discussion of the latest findings in the filled of cytokines and mechanical stretch of different tissues research. It is evident that the data, available on this topic is scarce, and this Volume is especially valuable, since its 10 Chapters provide a complete description of the modern vision of the field, which is rapidly developing. Volume begins with an overview of cytokines, addressed to those readers, who would like to get acquainted with this topic. In following Chapters authors summarize the recent findings about the cellular and molecular effect of mechanical stretch, which induce cytokine production in cardiomyocytes, fibroblasts, vascular smooth muscle cells, endothelial cells, lung and chondrocytes. Following description of mechanosensitive proinflammatory gene expression is of special interest. Chapters describing the role of major v vi Foreword
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
Contact Info
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Product
Resources
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.
