The learning in Biology Education Study Program at Sembilanbelas November Kolaka University, which was specifically designed to hone students' communication and collaboration skills, was considered not optimal. Therefore, a study was conducted to determine the effectiveness of integrating the time token learning model and wordwall application-based interactive games on student communication and collaboration skills. This research is a pre-experimental type with a one-group treatment design. The population was 144 students’, and 24 samples were obtained through the purposive sampling technique. The research data was collected through observation techniques with communication and collaboration skills observation sheets as instruments. Data were analyzed descriptively and inferentially followed by the N-Gain test. The results showed that the average scores for communication and collaboration skills before and during treatment were respectively 45.31 and 78.53; 42.19 and 86.64. The results of the paired sample t-test all show the sig. 0.000 < 0.05. The results of the N-Gain test on communication skills were 61.93% (effective enough category) and collaboration skills were 78.75% (effective category). Thus, it can be concluded that integrating time token learning models and interactive games based on wordwall applications effectively improves students' communication and collaboration skills.