Researchers have focused on identifying factors which might reduce the negative consequences associated with cyber victimization. One prominent factor receiving attention is the role of parental mediation in adolescents' digital technology usage, and how such mediation reduces the risk of cyber victimization. Less attention has focused on different mitigating agents (i.e., teachers, friends) and their influence on adolescents' cyber victimization. Another area that has received little attention is the buffering effects of different mitigating agents on the psychosocial adjustment difficulties (i.e., depression, loneliness, anxiety) associated with cyber victimization. To address this gap in the literature, the present study investigated the role of different mitigating agents (i.e., parents, teachers, friends) in buffering against the psychosocial adjustment difficulties associated with cyber victimization among 483 Chinese (49% female) and 467 American (52% female) adolescents in the eighth grade (ages ranging from [13][14][15]. Findings revealed that all adolescents experienced more mediation by their parents, with Chinese adolescents reporting more parental mediation when compared to American adolescents. Chinese adolescents also reported more teacher mediation, while American adolescents experienced more friend mediation. In addition, high levels of parental mediation made the relationship of cyber victimization to depression and anxiety more negative for both Chinese and American adolescents. The relationships of cyber victimization to depression and anxiety were moderated by teacher mediation for Chinese adolescents, whereas this pattern was not found for American adolescents. On the other hand, friend mediation moderated the relationship of cyber victimization to depression and anxiety for American adolescents, but not for Chinese adolescents. The results of this study are discussed in terms of cultural values and how such values alter the role of adults and friends in adolescents' lives.