Median Effective Dose of Intranasal Dexmedetomidine for Rescue Sedation in Pediatric Patients Undergoing Magnetic Resonance Imaging

Zhang, Wenhua; Fan, Yan-Ting; Zhao, Tianyun; Chen, Jinghui; Zhang, Gaolong; Song, Xingrong

doi:10.1097/aln.0000000000001353

Cited by 32 publications

(19 citation statements)

References 23 publications

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“…The result match those observed in earlier study. Zhang used intranasal dexmedetomidine as a rescue sedative, the study revealed that ED 50 of intranasal dexmedetomidine was 0.4 μg kg −1 in the age group of 1‐6 months and 1 μg kg −1 in those 25‐36 months, almost doubled in older children . There are several possible explanations for this result.…”

Section: Discussionmentioning

confidence: 99%

Median effective dose of intranasal dexmedetomidine sedation for transthoracic echocardiography in pediatric patients with noncyanotic congenital heart disease: An up‐and‐down sequential allocation trial

Liu

Sun

et al. 2017

Pediatric Anesthesia

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Section: Discussionmentioning

confidence: 99%

Median effective dose of intranasal dexmedetomidine sedation for transthoracic echocardiography in pediatric patients with noncyanotic congenital heart disease: An up‐and‐down sequential allocation trial

Liu

Sun

et al. 2017

Pediatric Anesthesia

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“…Dexmedetomidine can also be used as a rescue sedative. After failed chloral hydrate sedation, the rescue success rate of dexmedetomidine increases in a dose-dependent manner [27], and the effective dose 50 of dexmedetomidine for rescue increases with age in those younger than 3 years [28]. Compared with chloral hydrate, intranasal dexmedetomidine has a higher rescue success rate than a second dose of chloral hydrate after failed chloral hydrate sedation [29].…”

Section: Discussionmentioning

confidence: 99%

Moderate and deep sedation for non-invasive paediatric procedures in tertiary maternity and children’s hospitals in China: a questionnaire survey from China

Zhang

Huang

et al. 2020

BMC Health Serv Res

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Background: Moderate and deep sedation are well-established techniques in many developed countries, and several guidelines have been published. However, they have received attention in China only in recent years. The aim of this study is to investigate current paediatric sedation practices in tertiary children's hospitals and tertiary maternity and children hospitals in China. Methods: All tertiary children's hospitals and tertiary maternity and children hospitals registered with the National Health Commission of the People's Republic of China were invited to participate in an electronic survey, which included information on the sedation caseload, facility availability, staff structure, clinical skill requirements for sedation providers, fasting guidelines, patient-monitoring practices, and choice of sedatives. Results: Fifty-eight of the 63 hospitals that completed the survey (92.1%) provided moderate and deep sedation. Dedicated sedation rooms and post-sedation recovery rooms were found in 14 (24.1%) and 19 (32.8%) hospitals, respectively. Sedation for non-invasive procedures was primarily performed by anaesthesiologists (69.0%); however, 75.9% of the sedation providers had not received paediatric basic or advanced life-support training. Children were asked to fast from clear liquids for at least 2 h in 44.8% of hospitals and up to 6 h in 5.2% of hospitals; they were asked to fast from solid food/milk for at least 4 h in 27.6% of hospitals and more than 8 h in 1.7% of hospitals. The most commonly used sedative in all groups was chloral hydrate. For rescue, propofol was the most widely used sedative, particularly for children older than 4 years. Conclusions: Moderate and deep sedation practices vary widely in tertiary children's hospitals and tertiary maternity and children hospitals in China. Optimised practices should be established to improve the quality of moderate and deep sedation.

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“…Dexmedetomidine can also be used as a rescue sedative. After failed chloral hydrate sedation, the rescue success rate of dexmedetomidine increases in a dose-dependent manner 11 , and the effective dose 50 of dexmedetomidine for rescue increases with age in those younger than 3 years 26 . Compared with chloral hydrate, intranasal dexmedetomidine has a higher rescue success rate than a second dose of chloral hydrate after failed chloral hydrate sedation 27 .…”

Section: Choice Of Sedativesmentioning

confidence: 99%

Moderate and deep sedation for non-invasive paediatric procedures in tertiary maternity and children’s hospitals in China: A questionnaire survey from China

Zhang

Huang

et al. 2019

Preprint

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Background: Moderate and deep sedation are well-established techniques in many developed countries, and several guidelines have been published. However, they have received attention in China only in recent years. The aim of this study is to investigate current paediatric sedation practices in tertiary children’s hospitals and tertiary maternity and children hospitals in China. Methods: All tertiary children’s hospitals and tertiary maternity and children hospitals registered with the National Health Commission of the People’s Republic of China were invited to participate in an electronic survey, which included information on the sedation caseload, facility availability, staff structure, clinical-skill requirements for sedation providers, fasting guidelines, patient-monitoring practices, and choice of sedatives. Results: Fifty-eight of the 63 hospitals that completed the survey (92.1%) provided moderate and deep sedation. Dedicated sedation rooms and post-sedation recovery rooms were found in only 14 (24.1%) and 19 (32.8%) hospitals, respectively. Sedation for non-invasive procedures was primarily performed by anaesthesiologists (69.0%); however, 75.9% of the sedation providers had not received paediatric basic and advanced life-support training. Children were asked to fast from clear liquids for at least 2 h in 44.8% of hospitals and at most 6 h in 5.2% of hospitals; they were asked to fast from solid food/milk for at least 4 h in 27.6% of hospitals and more than 8 h in 1.7% of hospitals. The most commonly used sedative in all groups was chloral hydrate. For rescue, propofol was the most widely used sedative, particularly for children older than 4 years. Conclusion: Moderate and deep sedation practices vary widely in tertiary children’s hospitals and tertiary maternity and children hospitals in China. More optimized practices should be established to improve the quality of moderate and deep sedation.

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Median Effective Dose of Intranasal Dexmedetomidine for Rescue Sedation in Pediatric Patients Undergoing Magnetic Resonance Imaging

Cited by 32 publications

References 23 publications

Median effective dose of intranasal dexmedetomidine sedation for transthoracic echocardiography in pediatric patients with noncyanotic congenital heart disease: An up‐and‐down sequential allocation trial

Median effective dose of intranasal dexmedetomidine sedation for transthoracic echocardiography in pediatric patients with noncyanotic congenital heart disease: An up‐and‐down sequential allocation trial

Moderate and deep sedation for non-invasive paediatric procedures in tertiary maternity and children’s hospitals in China: a questionnaire survey from China

Moderate and deep sedation for non-invasive paediatric procedures in tertiary maternity and children’s hospitals in China: A questionnaire survey from China

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