Mediastinal hemangiopericytoma

Abstract

Mediastinal hemangiopericytoma (HPC) was diagnosed in a 3-year-old female. The incidence of this tumor is rare in children, and few data are available to guide clinical management. The surgical resection was incomplete and she received adjuvant radiation therapy and chemotherapy. The patient is alive without adverse events 6 years after diagnosis.

Mediastinal Hemangiopericytoma with Bone Metastases in a 2.5 Year-old-boy

“…Subsequently, two consecutive case reports with 4 and 5 years of age by Rafaat et al and Simonton et al emphasized the poor prognosis of these tumors due to anatomic site, local invasion leading to recurrences, and tendency to bleeding (7,8). Recently, Horikawa-Kyo et a.l reported a 3 yearold-girl with mediastinal HPC successfully treated with surgery, radiotherapy and chemotherapy despite positive resection margins (9). To our knowledge, our patient is the fifth mediastinal HPC in children after the first year of life and the unique case with bone metastases presented in the English literature.…”

“…The pulmonary localization is considerably rare and infiltration to chest wall and pleura may cause cough, hemoptysis, and dyspnea (5)(6)(7)(8)(9). Interestingly, our patient didn't suffer from respiratory problems and was diagnosed while being evaluated for the cardiac disease.…”

Rectal hemangiopericytoma in a 37-year-old woman: a case report and review of the literature

“…HPC is classified as a soft-tissue vascular tumor arising from pericytes, which are contractile cells surrounding the capillaries and post-capillary venules [5]. Consequently, HPC may occur anywhere capillaries are found.…”

Paediatric mesenchymal tumors of the mediastinum

“…The paediatric HPC may be clinically distinguished into two subtypes namely, infantile type (seen in children <1 year of age) or the adult type (children older than 1 year). The treatment for both the subtypes differ as the infantile type may regress with surgical therapy alone and even chemosensitive whereas the adult type is considered to have poorer prognosis ( 15 ).…”