2017
DOI: 10.1021/acs.nanolett.7b00021
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Mediating Passive Tumor Accumulation through Particle Size, Tumor Type, and Location

Abstract: As the enhanced permeation and retention (EPR) effect continues to be a controversial topic in nanomedicine, we sought to examine EPR as a function of nanoparticle size, tumor model, and tumor location, while also evaluating tumors for EPR mediating factors such as microvessel density, vascular permeability, lymphatics, stromal content, and tumor-associated immune cells. Tumor accumulation was evaluated for 55 × 60, 80 × 180, and 80 × 320 nm PRINT particles in four subcutaneous flank tumor models (SKOV3 human … Show more

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Cited by 221 publications
(127 citation statements)
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“…Although the targeting of EVs towards tumors has been extensively studied, the assessment of biodistribution has mostly focused on subcutaneous xenograft models, which permit easier follow up because of their large size and the high degree of vascularization [13,14]. Tracking EVs in metastasis can be challenging because of the small size of early tumors and the limitations of the light penetration, which is restricted to only a few millimiters.…”
Section: Introductionmentioning
confidence: 99%
“…Although the targeting of EVs towards tumors has been extensively studied, the assessment of biodistribution has mostly focused on subcutaneous xenograft models, which permit easier follow up because of their large size and the high degree of vascularization [13,14]. Tracking EVs in metastasis can be challenging because of the small size of early tumors and the limitations of the light penetration, which is restricted to only a few millimiters.…”
Section: Introductionmentioning
confidence: 99%
“…From these findings, it can also be inferred that swelling is actually displayed by hydrogel particles prepared by any materials (e.g., poly(hydroxyethyl acrylate) /PHEA, poly(ethylene glycol) diacrylate /PEGDA, derivatives of hydroxyl PEG acrylate groups, etc.) and methods (i.e., imprint lithography, irrespective from its subtypes, particle replication in nonwetting templates [PRINT], etc. ), but they are in the much lesser degree.…”
Section: Discussionmentioning
confidence: 99%
“…Lately, instead of optimizing the commercially available stabilizer and materials for supporting the excellent nonspherical particle shape stability, it is not surprising that the trend in finding and utilizing less hydrophobic novel polymers as particle core grows significantly. The eminent examples thereof encompass the members of hydroxyl PEG acrylate (HPA) group, such as triethylene glycol monoacrylate (TEGA), and tetraethylene glycol monoacrylate (HP 4 A) . Nevertheless, these new polymers have bulk T g much lower than their parent polymer PEGDA, where the hydrophobicity is inversely proportional to the length of hydrophilic side groups (e.g., i.e., T g TEGA ‐48 °C vs T g PEGDA ‐34 °C).…”
Section: Discussionmentioning
confidence: 99%
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“…Another factor, which has a direct impact on tumor accumulation, is the density of microvessels within the tumor. The density of microvessels varies based on tumor type 20…”
Section: Passive Targetingmentioning
confidence: 99%