The ongoing aggression war by Russia in Ukraine underscores the need to explore the impact of geopolitical crises on students' well-being within the system university. Previous studies have raised concern regarding rising mental health issues among students, exacerbated by war-related stressors. The effects extend to non-war-involved countries on several levels, with heightened anxiety and fear reported for students. In this study, the affectedness of well-being, perceived stress and work engagement among German medicine students is surveyed in a cross-sectional multi-methods study before and after the initial war occurrences in Ukraine were reported. Results show lessened well-being and increase perceived stress, but non significantly affected work engagement. The students report several demands and resources to cope with stressors and maintain ongoing study motivation and capability. By understanding the personal repercussions of systemic crises, this study seeks to identify longitudinal support needs for medical students navigating uncertain times.