Mediator-less highly sensitive voltammetric detection of glutamate using glutamate dehydrogenase/vertically aligned CNTs grown on silicon substrate

The design, development and application of electrochemical glutamate biosensors

“…The electrochemical technique known as different pulse voltammetry was used in conjunction with a glutamate biosensor to develop a novel assay for measuring glutamate in a mixture of naturally occurring biomolecules commonly found in biological samples [28]. The biosensor fabrication procedure involves vertically aligned carbon nanotubes (VACNTs) which are treated in order to convert the tips of the CNTs into carboxylic acid groups, in order to covalently bind the enzyme.…”

Graphene and tricobalt tetraoxide nanoparticles based biosensor for electrochemical glutamate sensing

“…The best current response obtained at 60 C glutamate measurements were performed at body temperature (37 C) because the response current was stable between 35 and 40 C. Moreover, the repeatability of the calibration curves obtained over 40 C was not satisfactory. Different temperatures such as 37 C (Chang and Chen 2007), 35 C (Basu et al 2006, Batra and Pundir 2013, Rahman et al 2005, 42 C (Gholizadeh et al 2012), 25 C (Maalouf et al 2007, Tang et al 2007, Tian et al 2009) were selected as optimum for glutamate biosensors.…”

“…It is an important neurotransmitter in the central nervous system and neuronal pathways in the brain which is related to several neurological disorders, such as epilepsy, stroke, Alzheimer's and Parkinson's diseases (Batra and Pundir 2013, Gholizadeh et al 2012, Jamal et al 2010. Moreover, its sodium salt, monosodium glutamate (MSG) is widely used as a flavor enhancing food additive and it has been associated with the Chinese restaurant syndrome.…”

Microelectronics-Based Biosensors Dedicated to the Detection of Neurotransmitters: A Review

“…The results showed that the GLDH/VACNT electrode was a suitable basic electrode for the detection of GLU, even without an electron mediator. They also reported the fabrication of a vertically-aligned carbon nanotube nanoelectrode array (VACNT-NEA) via the photolithography method [74]. The fabricated VACNT-NEA and high-density VACNTs were used as electrochemical GLU biosensors.…”