Mediator Subunit MED25 Couples Alternative Splicing of <i>JAZ</i> Genes with Fine-Tuning of Jasmonate Signaling

Wu, Fangming; Deng, Lijun; Zhai, Qingzhe; Zhao, Jiuhai; Chen, Qian; Li, Chuanyou

doi:10.1105/tpc.19.00583

Cited by 65 publications

(64 citation statements)

References 85 publications

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“…MED25 promotes transcription in the JA pathway via various mechanisms such as recruitment of RNA polymerase II, histone acyltransferase HAC1 and JA‐related enhancers to promoters that are targeted by for example MYC2 and ORA59 (Çevik et al ., 2012; Chen et al ., 2012; An et al ., 2017; Wang et al ., 2019; You et al ., 2019; Figure 2). Moreover, MED25 has a role in alternative splicing of JAZ proteins, which determines their sensitivity to JA (Wu et al ., 2020; Figure 2a). This multifaceted role makes MED25 an obvious candidate player in crosstalk regulation.…”

Section: Crosstalk At the Gene Expression Levelmentioning

confidence: 99%

Multiple levels of crosstalk in hormone networks regulating plant defense

2020

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Summary Plant hormones are essential for regulating the interactions between plants and their complex biotic and abiotic environments. Each hormone initiates a specific molecular pathway and these different hormone pathways are integrated in a complex network of synergistic, antagonistic and additive interactions. This inter‐pathway communication is called hormone crosstalk. By influencing the immune network topology, hormone crosstalk is essential for tailoring plant responses to diverse microbes and insects in diverse environmental and internal contexts. Crosstalk provides robustness to the immune system but also drives specificity of induced defense responses against the plethora of biotic interactors. Recent advances in dry‐lab and wet‐lab techniques have greatly enhanced our understanding of the broad‐scale effects of hormone crosstalk on immune network functioning and have revealed underlying principles of crosstalk mechanisms. Molecular studies have demonstrated that hormone crosstalk is modulated at multiple levels of regulation, such as by affecting protein stability, gene transcription and hormone homeostasis. These new insights into hormone crosstalk regulation of plant defense are reviewed here, with a focus on crosstalk acting on the jasmonic acid pathway in Arabidopsis thaliana, highlighting the transcription factors MYC2 and ORA59 as major targets for modulation by other hormones.

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Section: Crosstalk At the Gene Expression Levelmentioning

confidence: 99%

Multiple levels of crosstalk in hormone networks regulating plant defense

2020

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“…These results suggest that MED17, MED18 and MED20 possibly modulate vegetative phase change by affecting the biogenesis of noncoding RNAs, including miR159 and miR172 [42]. Moreover, MED25 is considered as an integrator of JA-mediated transcriptional activation by interacting with MYC2 (a basic helix-loop-helix transcription factor) and HAC1 (HISTONE ACETYLTRANSFERASE1) [43,44]; and MED25 also couples alternative splicing of JAZ (JASMONATE ZIM-DOMAIN) genes with fine tuning of JA signaling [45]. Based on the important function of JA signaling in vegetative phase change, whether MED25 plays a role in the regulation of vegetative phase change needs to be studied further.…”

Section: Functions In Vegetative Phase Change In Plantsmentioning

confidence: 98%

The Important Function of Mediator Complex in Controlling the Developmental Transitions in Plants

Zhang

Guo

2020

IJMS

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Developmental transitions in plants are tightly associated with changes in the transcriptional regulation of gene expression. One of the most important regulations is conferred by cofactors of RNA polymerase II including the mediator complex, a large complex with a modular organization. The mediator complex recruits transcription factors to bind to the specific sites of genes including protein-coding genes and non-coding RNA genes to promote or repress the transcription initiation and elongation using a protein-protein interaction module. Mediator complex subunits have been isolated and identified in plants and the function of most mediator subunits in whole life cycle plants have been revealed. Studies have shown that the Mediator complex is indispensable for the regulation of plant developmental transitions by recruiting age-, flowering-, or hormone-related transcription factors. Here, we first overviewed the Mediator subunits in plants, and then we summarized the specific Mediator subunits involved in developmental transitions, including vegetative phase change and floral transition. Finally, we proposed the future directions to further explore their roles in plants. The link between Mediator subunits and developmental transitions implies the necessity to explore targets of this complex as a potential application in developing high quality crop varieties.

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“…Intriguingly, JA also induces the recruitment of two splicing factors, PRE-mRNA-PROCESSING PROTEIN 39a (PRP39a) and PRP40a to JAZ loci by MED25. PRP39a and PRP40a, in turn, facilitate the full splicing of JAZ transcripts to produce the full-length JAZ proteins, thus preventing the excessive desensitization of JA responses caused by the overaccumulation of JAZ splice variants [ 115 ]. These data suggest that the JA-induced negative feedback mechanism by the alternative splicing of JAZ genes is under exquisite modulation.…”

Section: Ja Signalingmentioning

confidence: 99%

Jasmonic Acid Signaling and Molecular Crosstalk with Other Phytohormones

Liu

Timko

2021

IJMS

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Plants continually monitor their innate developmental status and external environment and make adjustments to balance growth, differentiation and stress responses using a complex and highly interconnected regulatory network composed of various signaling molecules and regulatory proteins. Phytohormones are an essential group of signaling molecules that work through a variety of different pathways conferring plasticity to adapt to the everchanging developmental and environmental cues. Of these, jasmonic acid (JA), a lipid-derived molecule, plays an essential function in controlling many different plant developmental and stress responses. In the past decades, significant progress has been made in our understanding of the molecular mechanisms that underlie JA metabolism, perception, signal transduction and its crosstalk with other phytohormone signaling pathways. In this review, we discuss the JA signaling pathways starting from its biosynthesis to JA-responsive gene expression, highlighting recent advances made in defining the key transcription factors and transcriptional regulatory proteins involved. We also discuss the nature and degree of crosstalk between JA and other phytohormone signaling pathways, highlighting recent breakthroughs that broaden our knowledge of the molecular bases underlying JA-regulated processes during plant development and biotic stress responses.

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Mediator Subunit MED25 Couples Alternative Splicing of JAZ Genes with Fine-Tuning of Jasmonate Signaling

Cited by 65 publications

References 85 publications

Multiple levels of crosstalk in hormone networks regulating plant defense

Multiple levels of crosstalk in hormone networks regulating plant defense

The Important Function of Mediator Complex in Controlling the Developmental Transitions in Plants

Jasmonic Acid Signaling and Molecular Crosstalk with Other Phytohormones

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