Socio-psychological disadaptation in children and adolescents at the present time should be considered not only from the perspective of existing disorders of the emotional state and limitations of sociability but also from the standpoint of the deterioration of their somatic health and quality of life. The purpose of the research is to carry out comparative study of the level of body resistance in schoolchildren of the Uzbek population with socio-psychological maladjustment studying in different academic conditions. To achieve the set goal, clinical, clinical-psychological, and epidemiological research methods were chosen. In addition, psychopathological and paraclinical analyses were conducted, and long-term results were monitored. Disruption of adaptation mechanisms and unsatisfactory adaptation are more common in adolescent boys, regardless of the type of education (30.1% and 24.1% in boys with traditional education, 26.2% and 19.7% in boarding lyceums, P >0.05- > 0.01). Among all surveyed girls with maladjustment, adolescent girls with traditional education were more likely to have a breakdown in adaptation mechanisms (20.7% versus 16.9%, P > 0.05). Tense adaptation mechanisms were also predominantly recorded in adolescent boys in both study groups (64.3% and 67.6%, respectively), which has to be well considered when organizing preventive measures. The developed method for assessing the development of disadaptation, based on a systematic analysis of risk factors, considering the clinical and psychological characteristics of the child’s development, personality, family structure and teaching methods, the state of the central nervous system, and hormonal changes, facilitates the diagnostic procedure before the onset of clinical signs of maladjustment.