Medical and Psychosocial Factors in Enuretic Children Treated with Imipramine Hydrochloride

Bindelglas, Paul M.; Dee, George; Enos, Francis A.

doi:10.1176/ajp.124.8.1107

Cited by 13 publications

(2 citation statements)

References 11 publications

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“…Among various purported therapeutic interventions, tricyclic antidepressants (TCA) are the single class of medications which have been demonstrated to be effective in controlling enuresis. Approximately 50%-60% of children taking imipramine (IMI), a common TCA, will have at least a 50% reduction of wetting frequency (Bindeglas et al, 1968) usually within the first week of use (Rapoport et al, 1980). The effectiveness of IMI does not seem to be related to its antidepressant effect, because it is equally useful for children with and without psychiatric disorders, and the onset of its effectiveness occurs within 7 days, vs. up to 14 days for its antidepressant effect (Shaffer et al, 1968).…”

Section: Introductionmentioning

confidence: 99%

A double-blind, placebo-controlled study of the effect of imipramine on TRH-induced urinary urgency in healthy men

Alessi

Knight

Bergs

et al. 1992

Psychoneuroendocrinology

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We studied the effect of imipramine (IMI) on thyroid releasing hormone (TRH)-induced urinary urgency as a way of investigating the mechanism of the beneficial effect of IMI on enuresis. In a double-blind study, 12 normal, healthy men between 21 and 39 yr of age ranked their urge to urinate at 30-sec intervals following IV injection of TRH (500 micrograms) or saline. The subjects then were randomly assigned to either IMI (1 mg/kg) or placebo groups for 10 days, and the procedure was repeated. Compared to saline, TRH produced a significant elevation in urinary urgency in all subjects. IMI did not significantly blunt TRH-induced urinary urgency. Thus, the mechanism by which IMI affects enuresis is likely not mediated at the level of the urinary urgency induced by TRH.

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Section: Introductionmentioning

confidence: 99%

A double-blind, placebo-controlled study of the effect of imipramine on TRH-induced urinary urgency in healthy men

Alessi

Knight

Bergs

et al. 1992

Psychoneuroendocrinology

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“…Since research has shown that the conditioning treatment for enuresis is highly successful, establishment of an ongoing conditioning treatment program within a medical setting is needed. It should be noted that the use of drugs (Bindelglas, Dee, & Enos, 1968;Bostock, 1962;Breger, 1962;Miller, Champelli, & Dinello, 1968;Munster, Stanley, & Saunders, 1961;Poussaint & Ditman, 1965) has been moderately successful but less successful than the rates reported for conditioning (Lovibond & Coote, 1970;Yates, 1970), and relapse rate in the foregoing drug studies has reportedly been larger than the relapse rate cited in conditioning studies.…”

mentioning

confidence: 98%

Behavior modification of nocturnal enuresis: A treatment and research program at the Mayo Clinic.

Schwartz¹,

Colligan²,

O’Connell³

1972

Professional Psychology

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Imipramine Pamoate in the Treatment of Childhood Enuresis

Martin¹

1971

Am J Dis Child

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Imipramine pamoate suspension was administered orally to 57 healthy children in a double-blind crossover design study with dosage sequence randomized to determine whether 10 or 25 mg daily would be more effective in controlling nocturnal enuresis, when compared to treatment with a placebo. Both dosage levels of imipramine produced a statistically significant decrease in the number of wet nights when compared to placebo therapy (P<0.01). After the double-blind trial, imipramine treatment was continued in 18 patients at several dosage levels for three months. After discontinuing therapy, there was significantly fewer wet nights than during the final period of drug treatment. Complete monitoring of several laboratory determinations revealed no significant abnormalities at dosages employed. A unified concept concerning the action of imipramine in enuresis, with emphasis on micturition, maturation of neural pathways, and the level of sleep is discussed.Si nce the first observation by MacLean1 on the application of imipramine hydrochloride (Tofranil) in the management of enuresis, over 100 investigations have appeared on the subject. Statistical evaluation of well controlled investigations show that imipramine is superior to pla¬ cebo in decreasing wetting frequen¬ cy. Uncertainty still exists con¬ cerning the drug's proper dosage, length of administration, and meth¬ od of drug withdrawal. Accordingly, imipramine in the pa¬ moate suspension was administered to 57 healthy children in a doubleblind controlled trial to determine the appropriate dosage level in con¬ trolling nocturnal enuresis. In the second part of the investigation, the continuing effect of the pamoate sus¬ pension in various dosage levels was

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Medical and Psychosocial Factors in Enuretic Children Treated with Imipramine Hydrochloride

Cited by 13 publications

References 11 publications

A double-blind, placebo-controlled study of the effect of imipramine on TRH-induced urinary urgency in healthy men

A double-blind, placebo-controlled study of the effect of imipramine on TRH-induced urinary urgency in healthy men

Behavior modification of nocturnal enuresis: A treatment and research program at the Mayo Clinic.

Imipramine Pamoate in the Treatment of Childhood Enuresis

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