Medical Applications and Toxicities of Gallium Compounds

Chitambar, Christopher R.

doi:10.3390/ijerph7052337

Cited by 317 publications

(249 citation statements)

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“…Gallium (Ga) is a known chemotherapeutic ion and its biological function has been approved by food and drug administration (FDA) [12,13]. It is also accepted that Ga prevents osteoclast bone resorption by increasing calcium (Ca) concentration without influencing osteoblasts [14].…”

Section: Introductionmentioning

confidence: 99%

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Fabrication and characterization of poly(octanediol citrate)/gallium-containing bioglass microcomposite scaffolds

et al. 2014

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Bone can be affected by osteosarcomae requiring surgical excision of the tumor as part of the treatment regime. Complete removal of cancerous cells is difficult and conventionally requires the removal of a margin of safety around the tumor to offer improved patient prognosis. This work considers a novel series of composite scaffolds based on poly(octanediol citrate) (POC) impregnated with galliumbased bioglass microparticles for possible incorporation into bone following tumor removal. The objective of this research was to fabricate and characterize these scaffolds and subsequently report on their mechanical and biological properties. The porous microcomposite scaffolds with various concentrations of bioglass (10, 20, 30 wt%) incorporated were fabricated using a salt leaching technique. The scaffolds exhibited compression modulus in the range of 0.3-7 MPa. The addition of bioglass increased the mechanical properties even though porosity increased. Furthermore, increasing the concentration of bioglass had a significant influence on glass transition temperature from 2.5°C for the pure polymer to around 25°C for 30 % bioglass-containing composite. The ion release study revealed that composites containing 10 % bioglass had the highest ion release ratio after 28 days of soaking in phosphate buffered saline. The interaction of bioglass phase with POC led to the formation of additional ionic crosslinks aside from covalent crosslinks which further resulted in increased stiffness and decreased weight loss. The osteoblast cells were well attached and growth on composites and collagen synthesis increased particularly with the 10 % bioglass concentration.

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Section: Introductionmentioning

confidence: 99%

“…The anti-inflammatory and immunosuppressive Ga-compounds have also been proven to work in animal models of human diseases [12,15]. In order to utilize the potential of Ga-containing bioglass, they need to be delivered to the body in scaffolds with a controlled release dosage form.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and characterization of poly(octanediol citrate)/gallium-containing bioglass microcomposite scaffolds

et al. 2014

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“…Investigating the antineoplastic activity of Ga, the effect of intratracheal administration of gallium arsenate in rats was also studied. The doses used experimentally in rats, according to a review by Chitambar (2010) [71], varied widely, from 0.6 mg/kg b.w. administered twice per week and lasting 4 weeks, up to 100 mg/kg b.w.…”

Section: In Vivo Studiesmentioning

confidence: 99%

“…The effects on lungs, kidneys, testicles and haeme biosynthesis as well as immunological effects were evaluated in this context. Many authors performed studies by orally administering doses from 10 to 1000 mg/ gallium arsenide [71].…”

Section: In Vivo Studiesmentioning

confidence: 99%

Metallomics related to gallium compounds: biochemical and xenobiochemical aspects

Gârban¹,

Silaghi‐Dumitrescu

Gârban³

et al. 2014

Maced. J. Chem. Chem. Eng.

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Issues concerning chemical compounds studied in the framework of metallomics are of interest both for the domain of biochemistry dealing with the metabolization of nutrients and for xenobiochemistry -a different domain of biochemistry dealing with the biodegradation of xenobiotics. In this context, in vivo and in vitro data are reviewed here on inorganic and organo-metallic compounds of gallium (Ga), ranging from cellular and molecular biology to biochemistry and pathobiochemistry and on to pharmacology and its relations to homeostasis and nutrient degradation.Keywords: gallium compounds -biochemistry; xenobiochemistry; biomedical effects; in vivo; in vitro МЕТАЛОМИКА НА ГАЛИУМОВИ СОЕДИНЕНИЈА: БИОХЕМИСКИ И КСЕНОБИОХЕМИСКИ АСПЕКТИ Проблемите поврзани со хемиските соединенија од областа на металомиката се од интерес не само за биохемијата -домен што се занимава со метаболизмот на хранливите состојки, туку и за ксенобиохемијата -дел од биохемијата што се занимава со биодеградацијата на ксено-биотиците. Во овој труд е направен преглед на податоците in vitro и in vivo за неоргански и органски соединенија на галиум, од аспект на клеточна и молекуларна биологија до биохемија и патобиохемија и фармакологија во однос на хомеостазата и разложувањето на хранливите состојки.Клучни зборови: биохемија; ксенобиохимија; биомедицинско дејство; соединенија на галиум in vivo; in vitro

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“…Gallium is used primarily in diagnostics, but reports have indicated that it may have potential in a therapeutic capacity [36]. A series of gallium complexes with two pyridine phenolate ligands with asymmetric NN'O donor groups were tested for their ability to inhibit proteasome activity and induce apoptosis in C4-2B prostate cancer cells.…”

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confidence: 99%