Metallomics related to gallium compounds: biochemical and xenobiochemical aspects

Abstract

Issues concerning chemical compounds studied in the framework of metallomics are of interest both for the domain of biochemistry dealing with the metabolization of nutrients and for xenobiochemistry -a different domain of biochemistry dealing with the biodegradation of xenobiotics. In this context, in vivo and in vitro data are reviewed here on inorganic and organo-metallic compounds of gallium (Ga), ranging from cellular and molecular biology to biochemistry and pathobiochemistry and on to pharmacology and its relations to homeostasis and nutrient degradation.Keywords: gallium compounds -biochemistry; xenobiochemistry; biomedical effects; in vivo; in vitro МЕТАЛОМИКА НА ГАЛИУМОВИ СОЕДИНЕНИЈА: БИОХЕМИСКИ И КСЕНОБИОХЕМИСКИ АСПЕКТИ Проблемите поврзани со хемиските соединенија од областа на металомиката се од интерес не само за биохемијата -домен што се занимава со метаболизмот на хранливите состојки, туку и за ксенобиохемијата -дел од биохемијата што се занимава со биодеградацијата на ксено-биотиците. Во овој труд е направен преглед на податоците in vitro и in vivo за неоргански и органски соединенија на галиум, од аспект на клеточна и молекуларна биологија до биохемија и патобиохемија и фармакологија во однос на хомеостазата и разложувањето на хранливите состојки.Клучни зборови: биохемија; ксенобиохимија; биомедицинско дејство; соединенија на галиум in vivo; in vitro

Coordination compounds in cancer: Past, present and perspectives

“…Gallium is a metalloid that has been used in different medical applications, such as the treatment of accelerated bone resorption, autoimmune and infective diseases (Gârban et al, 2014). Using the isotope 67 Ga for imaging in rodents, it has been reported that gallium accumulates in tumour tissues.…”

Characterization and Some Physicochemical Aspects of Pathological Microcalcifications

“…Finally, special attention must be paid to the presence of trace elements and molecular groups at the surface or inside the mineral. , These trace elements have been the subject of numerous studies in chemistry or medicine − to elucidate their role regarding the crystal formation kinetics , or the morphologic features of the mineral . A recent study highlighted that Zn may have an inhibitory effect on calcium oxalate (CaOx) stone formation, whereas Fe and Cu could promote CaOx stone formation. , The carbonate level of biological apatites is also an interesting feature.…”

Evaluation of Immobilized Metal-Ion Affinity Chromatography and Electrospray Ionization Tandem Mass Spectrometry for Recovery and Identification of Copper(II)-Binding Ligands in Seawater Using the Model Ligand 8-Hydroxyquinoline

“…The compound chosen was 8-hydroxyquinoline (8-HQ), a wellcharacterized model ligand that is amenable to ESI-MS and forms strong 1:2 metal:ligand complexes with Cu 2+ at pH 8 (log β 2 = 18.3; Perrin, 1979;Ross et al, 1998). The ability of 8-HQ to form uncharged, lipophilic complexes makes it a viable model for biological metal-ion carriers (Gârban et al, 2014) as well as for marine Cu-complexing ligands. We also present Cu(II)-IMAC data for oceanic and coastal surface waters using multiple detection wavelengths, which enable fractionation of marine Cu ligands based on UV absorbance and IMAC retention times.…”