Medical Applications of Magnetorheological Fluids a Possible New Cancer Therapy

Flores, G. A.; Sheng, Ruanmei; Liu, J.

doi:10.1106/djx7-r39a-xkob-2xan

Cited by 9 publications

(10 citation statements)

References 3 publications

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“…In the absence of an external magnetic field (off-state), particles are randomly dispersed in the carrier liquid. 16 Also, biomedical applications such as drug targeting 17 or hyperthermia in cancer therapy 18 have been recently studied with regard to these systems. After the application of an external field (on-state), the particles are polarized and in a fraction of a millisecond create highly-organized structures, which results in the predominance of magnetic forces over hydrodynamic ones.…”

Section: Introductionmentioning

confidence: 99%

A facile controllable coating of carbonyl iron particles with poly(glycidyl methacrylate): a tool for adjusting MR response and stability properties

et al. 2015

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This study is focused on the controllable coating of the carbonyl iron (CI) particles widely applied in magnetorheology. These particles were grafted with poly(glycidyl methacrylate) (PGMA) with narrow polydispersity via surface-initiated atom transfer radical polymerization. Two types of core-shell particles differing in molecular weights of grafted polymer chains were synthesized. The effect of shell thickness on the thermo-oxidation stability of particles as well as the sedimentation stability of their silicone oil suspensions was evaluated. The successful coating process was confirmed by Fourier transform infrared spectroscopy and energy-dispersive spectrometry. The differences in the magnetic properties of bare and coated CI particles were clarified through vibrating sample magnetometry. Due to the controllable length of the PGMA grafts, the magnetic properties remain almost the same as those for bare CI. The magnetorheological (MR) behavior of silicone oil suspensions containing 60 wt% of bare CI particles as well as PGMA-coated analogues was investigated in the absence and in the presence of various magnetic field strengths, demonstrating the negligible impact of surface modification on final MR performance. Thus, the grafting of the particles with PGMA negligibly affected magnetic properties but considerably enhanced thermo-oxidation and sedimentation stabilities. Finally, a novel tensiometric method for sedimentation stability measurements of MR suspensions was successfully implemented.

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Section: Introductionmentioning

confidence: 99%

A facile controllable coating of carbonyl iron particles with poly(glycidyl methacrylate): a tool for adjusting MR response and stability properties

et al. 2015

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“…Our early work showed that blocking the fluid flow is possible within a single-tube system, simulating one blood vessel. We found that the seal remains even at pressures exceeding those found inside human arterioles and capillaries (Flores et al, 2000;Liu et al, 2001). We also found the dependency upon particle concentration, flow rate and magnetic field strength in the seal formation: The lower the particle volume fraction, the slower the flow rate and the weaker the magnetic field are, the weaker the formed seal is and the longer the sealing time is needed (Flores et al, 1999;Liu et al, 2001).…”

Section: Introductionmentioning

confidence: 70%

Embolization of Blood Vessels as a Cancer Therapy Using Magnetorheological Fluids

Flores

Liu

2002

Journal of Intelligent Material Systems and Structures

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This paper demonstrates a possible in vitro cancer therapy by mechanically blocking the blood vessels to a tumor through injecting a model magnetorheological (MR) fluid and applying an external magnetic field. The biocompatible MR fluid is made of magnetite particles coated with starch and suspended in either water or sheep blood. Two particle sizes of 1.0 and 0.25 μm are used. A simple blood network consists of four branches of blood vessels made of silicone tubes of 0.4 mm in diameter. One of the branches contains a tumor made of a cylindrical cavity with a diameter of either 3.0 or 5.0 mm to simulate stage II or III tumors. The cavity is connected with either two or four vessels to the rest of the branch and is placed between two magnetic poles. By measuring the weight of the leaking fluid downstream from the magnets, the sealing quality is monitored. A dilute MR fluid (1.0% particle volume fraction) is pumped slowly through the network. As the fluid goes through the cavity, seals form within seconds after a magnetic field (0.43-0.62 T) is turned on. They block the fluid flow to the tumor. With sheep blood as the suspension medium, both size of magnetite particles form a good quality seal for the 3 mm cavity. Thus, a mechanical method for stopping blood flow is demonstrated in a multi-tube blood network for stage II tumor.

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“…Flores et al [154] used MR suspensions based on water and composite magnetizable particles. For volume fractions of the solid phase of 0.25%, 1.0%, 2.0% and 5.0%, they determine the times of zero velocities of the movement of MR suspensions through 3.2 mm tubes in an induction magnetic field B !…”

Section: Possible Cancer Therapymentioning

confidence: 99%

Physical characteristics of magnetorheological suspensions and their applications

Bîcă¹,

Liu²,

Choi³

2013

Journal of Industrial and Engineering Chemistry

175

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Medical Applications of Magnetorheological Fluids a Possible New Cancer Therapy

Cited by 9 publications

References 3 publications

A facile controllable coating of carbonyl iron particles with poly(glycidyl methacrylate): a tool for adjusting MR response and stability properties

A facile controllable coating of carbonyl iron particles with poly(glycidyl methacrylate): a tool for adjusting MR response and stability properties

Embolization of Blood Vessels as a Cancer Therapy Using Magnetorheological Fluids

Physical characteristics of magnetorheological suspensions and their applications

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